Is NCT06980025 recruiting in Columbus, OH?

Yes, NCT06980025 is currently recruiting participants at its Columbus, OH location. This preterm birth clinical trial is actively enrolling qualified participants.

How do I join the preterm birth clinical trial in Columbus?

To join this clinical trial in Columbus, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Columbus clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Preterm Birth Clinical Trial in Columbus, OH

About This Preterm Birth Study in Columbus

This is a phase-III multi-center double-blind randomized clinical trial of 1,800 individuals with a history of prior preterm birth at less than 35 weeks gestation who are randomized to either 162 mg aspirin or 81 mg aspirin daily. The study drug will be initiated between 10 and 15 weeks gestation and continued through 36 weeks, 6 days gestation. The primary endpoint is recurrent preterm delivery or fetal death prior to 35 weeks, 0 days gestation.

Sponsor: The George Washington University Biostatistics Center

Who Can Participate

Inclusion Criteria

14 years or older

Singleton gestation. Twin gestation reduced to a singleton, either spontaneously or therapeutically, is not eligible unless the reduction occurred before 13 weeks 6 days project gestational age. Higher-order multifetal gestations reduced to singletons are not eligible.

Gestational age at randomization between 10 weeks 0 days and 15 weeks 6 days based on clinical information and evaluation of the earliest ultrasound.

Prior preterm birth between 20 weeks 0 days and 34 weeks 6 days with one of the following in the proximal birth reaching 20 weeks or greater:

Spontaneous preterm birth is defined as spontaneous preterm labor or premature rupture of membranes

Ischemic placental disease is defined as preeclampsia, small for gestational age, fetal growth restriction, or placental abruption, as defined clinically.

Stillbirth excluding those with known genetic disorders or major congenital anomalies.

Exclusion Criteria

Known allergy or hypersensitivity to aspirin or any medical condition where aspirin is contraindicated (e.g., history of peptic ulcer disease, nasal polyps, NSAID-induced asthma, history of gastrointestinal bleeding, known G6PD deficiency, severe hepatic dysfunction, bleeding disorders, and consumption of 3 or more alcoholic drinks per day)

Taking other anticoagulants such as Heparin or Low-Molecular weight Heparin

Thrombocytopenia defined as a platelet count defined as a platelet count \<100,000 microliters

Gastric bypass surgery, regardless of type

Aspirin use \>81 mg daily during the current pregnancy who are not willing or able to go through a 2-week washout before randomization.

Known major Mullerian anomaly of the uterus (specifically bicornuate, unicornuate, or uterine septum not resected) due to increased risk of preterm delivery.

Known fetal genetic disease or major malformations

Fetal demise or planned termination of pregnancy. Selective reduction by 13 weeks 6 days gestation, from twins to singleton, is not an exclusion.

Any fetal/maternal condition requiring invasive in-utero assessment or treatment, for example, significant red cell antigen sensitization or neonatal alloimmune thrombocytopenia.

Patients with any of the following medical conditions because of increased risk for adverse pregnancy outcome or indicated preterm birth:

Treated hypertension requiring more than one agent

Chronic renal disease with baseline serum creatinine ≥1.5 mg/dL

Conditions treated with chronic oral glucocorticoid therapy (e.g., systemic lupus erythematosus)

Uncontrolled hyper- and hypothyroid disease

New York Heart Association (NYHA) stage II or greater cardiac disease

Planned indicated delivery prior to 37 weeks.

Participation in another interventional study that influences the primary outcome in this study (gestational age at delivery).

Participation in this trial in a previous pregnancy.

Delivery planned at a non-participating site

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Columbus?

Yes, this clinical trial (NCT06980025) has an active research site in Columbus, OH that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Preterm Birth Treatment Options in Columbus, OH

If you're searching for preterm birth treatment options in Columbus, OH, this clinical trial (NCT06980025) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Columbus research site is actively enrolling participants for this phase 3 clinical trial. You'll receive care from experienced preterm birth specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all preterm birth clinical trials near you to find additional studies recruiting in your area.

Preterm Birth Clinical Trial in Columbus, OH

Expert Care in Columbus

IRB Approved

No-Cost Care

Apply for This Columbus Location

Why Participate?

Simple Process