NCT07526545 · University of Michigan Rogel Cancer Center
Urine Prostate Screening Integrated With MRI for Early Detection of Prostate Cancer, UPRISE Trial
(UPRISE)
What this study is about
This clinical trial tests how well a urine prostate cancer screening test, My Prostate Score 2 (MPS2), integrated with magnetic resonance imaging (MRI) works for early detection of prostate cancer. MPS2 is an experimental urine-based test designed to help identify the likelihood of having aggressive prostate cancer.
View original scientific description
This clinical trial tests how well a urine prostate cancer screening test, My Prostate Score 2 (MPS2), integrated with magnetic resonance imaging (MRI) works for early detection of prostate cancer. MPS2 is an investigational urine-based test designed to help identify the likelihood of having aggressive prostate cancer. MPS2 testing works by measuring specific early detection biomarkers that include genetic information. This next-generation test aims to address a major challenge in prostate cancer care-detecting only the cancers that truly need treatment. Results may lead to paradigm shifts in early detection algorithms and reduce reliance on MRI and biopsy.
Interventions
PROCEDURE
Biopsy Procedure
Undergo biopsy
DEVICE
Diagnostic Procedure
Undergo MPS2 urine test
OTHER
Electronic Health Record Review
Ancillary studies
PROCEDURE
Magnetic Resonance Imaging
Undergo MRI
Primary outcome measures
Clinically significant prostate cancer (csPCa), defined as Gleason Grade (GG) Group 2-5
Time frame: Up to 120 days
Will compare the proportions of patients with detected csPCa in the intervention and control arms (p1 and p2, respectively) using the OBrien Fleming stopping boundaries which control the overall one-sided Type I error rate to be less than .10.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Males aged 50-75
- PSA 3-20 ng/ml within the previous 3 months
- Fit to undergo all procedures listed in protocol per treating physician's discretion
- No prostate biopsy in the past 4 years
- No prostate MRI in the past 2 years
- Able to provide written informed consent
Exclusion criteria
- Prior diagnosis of prostate cancer
- Contraindication to MRI (e.g. claustrophobia, pacemaker)
- Contraindication to prostate biopsy
- Previous hip replacement surgery, metallic hip replacement or extensive pelvic orthopaedic metal work
Where
- Ann Arbor, Michigan
Collaborators
National Institutes of Health (NIH), National Cancer Institute (NCI)
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Oct 15, 2026 · Source of record for eligibility and locations