Tappahannock, VANCT04643366Now EnrollingIRB Ready

Rectal Cancer Clinical Trial in Tappahannock, VA

Access cutting-edge rectal cancer treatment through this phase 2 clinical trial at a research site in Tappahannock. Study-provided care at no cost to qualified participants.

Sponsored by Virginia Commonwealth University

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Expert Care in Tappahannock

Access rectal cancer specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related rectal cancer treatment provided free

Apply for This Tappahannock Location

Check if you qualify for this rectal cancer clinical trial in Tappahannock, VA

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Tappahannock

    Convenient for VA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Tappahannock site if eligible
  4. 4Begin participation

About This Rectal Cancer Study in Tappahannock

This is phase 2 trial of neoadjuvant therapy and short-course radiotherapy in resectable rectal cancer.

Sponsor: Virginia Commonwealth University

Who Can Participate

Inclusion Criteria

Pathologic diagnosis of adenocarcinoma of the rectum (diagnosis by tissue biopsy) within 90 days prior to registration. At least a portion of the tumor must be located below the peritoneal reflection or begin within 12 cm of the anal verge on flexible endoscopy
Clinically staged (AJCC 8th ed.) T3-4 N0 M0 or T any N1-2 M0 based upon the following minimum diagnostic workup:
Colonoscopy, unless patient presents with an obstructing lesion
Within 30 days before initiating MFOLFOX6 treatment:
History/physical examination
Imaging to exclude distant metastases: either contrast-enhanced CT of the chest, abdomen, and pelvis; or whole-body PET-CT; or MRI
Pelvic MRI (preferred) or transrectal ultrasound (TRUS) for T staging Note: Patients may have initiated standard mFOLFOX6 treatment before study registration provided that they met the above criteria before initiating treatment and can feasibly continue to CRT according to the timeline described in Section
ECOG Performance Status ≤2
Age ≥ 18 years
Adequate bone marrow function defined as follows:
Absolute neutrophil count (ANC) ≥ 1,200 cells/mm3
Platelets ≥ 100,000 cells/mm3
Hemoglobin ≥ 8.0 g/dL (Note: The use of transfusion or other intervention to achieve Hgb ≥8.0 g/dL is acceptable.)
Adequate liver and renal function defined as follows:
AST and alkaline phosphatase \< 2.5 x upper limit of normal (ULN)
Bilirubin ≤ 2.5 ULN
Calculated creatinine clearance (CrCl) \> 30 mL/min using Cockcroft-Gault formula as calculated by the standard Cockcroft-Gault equation using age, actual weight, creatinine, and gender
Must be deemed a candidate for curative resection by the surgical oncologist who will be performing the operation
Women of childbearing potential (WCBP) must have a negative serum pregnancy test performed within 7 days prior to the start of chemotherapy.
WCBP and men must agree to use a medically accepted form of birth control during the treatment and for 3 months following completion of chemotherapy.
Ability to understand and the willingness to sign a written informed consent document.

Exclusion Criteria

Prior RT that would result in unsafe overlap of RT fields with the planned study treatment, per the treating radiation oncologist
Clinically significant cardiac disease, including major cardiac dysfunction, that in the opinion of the treating medical oncologist would preclude them from receiving systemic therapy with 5-fluorouracil, leucovorin or oxaliplatin.
Serious (ie, ≥ grade 3) uncontrolled infection
Pulmonary or respiratory condition that, in the opinion of the treating medical oncologist would preclude them from receiving systemic therapy with 5-fluorouracil, leucovorin or oxaliplatin.
Major surgery within 28 days of study enrollment (other than diverting colostomy)
History of inflammatory bowel disease (eg, Crohn's disease, ulcerative colitis) requiring significant intervention (eg, hospitalization, surgery, immunosuppressive medications) that would, in the opinion of the investigator, preclude study therapy
Prior known allergic reaction to 5-fluorouracil, leucovorin, or oxaliplatin
Known dipyrimidine dehydrogenase deficiency (DPD)
Any evidence of distant metastases (M1)
Pregnant or breast feeding
Medical, psychological, or social condition that, in the opinion of the investigator, may increase the patient's risk or limit the patient's adherence with study requirements

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Tappahannock?

Yes, this clinical trial (NCT04643366) has an active research site in Tappahannock, VA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Rectal Cancer Treatment Options in Tappahannock, VA

If you're searching for rectal cancer treatment options in Tappahannock, VA, this clinical trial (NCT04643366) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Tappahannock research site is actively enrolling participants for this phase 2 clinical trial. You'll receive care from experienced rectal cancer specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all rectal cancer clinical trials near you to find additional studies recruiting in your area.

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