Duarte, CANCT05370430Now EnrollingIRB Ready

Relapsed or Refractory B-cell Non-Hodgkin's Lymphoma Clinical Trial in Duarte, CA

Access cutting-edge relapsed or refractory b-cell non-hodgkin's lymphoma treatment through this clinical trial at a research site in Duarte. Study-provided care at no cost to qualified participants.

Sponsored by PeproMene Bio, Inc.

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Expert Care in Duarte

Access relapsed or refractory b-cell non-hodgkin's lymphoma specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related relapsed or refractory b-cell non-hodgkin's lymphoma treatment provided free

Apply for This Duarte Location

Check if you qualify for this relapsed or refractory b-cell non-hodgkin's lymphoma clinical trial in Duarte, CA

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Duarte

    Convenient for CA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Duarte site if eligible
  4. 4Begin participation

About This Relapsed or Refractory B-cell Non-Hodgkin's Lymphoma Study in Duarte

A Phase 1 Study Evaluating BAFFR-targeting CAR T Cells for Patients with Relapsed or Refractory B-cell Non-Hodgkin's Lymphoma (B-NHL)

Sponsor: PeproMene Bio, Inc.

Who Can Participate

Inclusion Criteria

Informed Consent: Signed informed consent by the participant or legally authorized representative.
Age \& Performance Status:
Age ≥ 18 years
ECOG performance status ≤ 2
Diagnosis \& Disease Criteria:
Histologically confirmed B-NHL, including LBCL, MCL, and FL/MZL subtypes meeting specified prior treatment conditions.
BAFF-R expression on lymphoma cells required.
Measurable Disease: Tumor ≥1.5 cm on CT/PET scan or evidence of disease in blood, BM, GI, skin, or spleen.
Prior CAR T-cell Therapy: Allowed if ≥ 3 months since last treatment and CD19 CAR-T persistence \< 5% before leukapheresis.
Organ Function \& Laboratory Criteria:
Hematologic: ANC ≥ 1000/μL, Platelets ≥ 75,000/μL (exceptions for BM involvement).
Liver Function: Bilirubin ≤ 1.5x ULN (except Gilbert's), AST/ALT \< 3x ULN.
Renal Function: CrCl ≥ 50 mL/min.
Cardiac \& Pulmonary: LVEF ≥ 45%, QTcF ≤ 480 ms, O₂ saturation \> 91% on room air.
Infectious Disease Screening: Seronegative for HIV, active HBV, active HCV (or undetectable viral load if positive).
Reproductive Considerations:
Negative pregnancy test for females of childbearing potential.
Use of effective contraception or abstinence through 3 months post-treatment.

Exclusion Criteria

Prior Therapies \& Transplants:
Prior allogeneic SCT.
Autologous SCT \< 6 months before leukapheresis.
Concurrent systemic steroids or chronic immunosuppressant use.
Disease-Specific Exclusions:
Cardiac lymphoma involvement.
Need for urgent therapy due to tumor-related complications (e.g., bowel obstruction).
Medical Conditions:
Active autoimmune disease requiring immunosuppressants.
Primary immunodeficiency.
Cardiac conditions, including NYHA Class III/IV heart disease, arrhythmia, recent MI (≤ 6 months), stroke (≤ 6 months), or significant VTE (≤ 6 months).
Neurologic conditions, including prior optic neuritis, CNS inflammatory diseases, or seizure disorders.
History of malignancy, unless resected/treated with curative intent or in remission for ≥ 3 years.
Uncontrolled systemic infections or active CNS lymphoma.
Pregnancy \& Breastfeeding: Females who are pregnant or nursing.
Other Considerations:
Investigator-determined safety concerns.
Potential noncompliance with study procedures.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Duarte?

Yes, this clinical trial (NCT05370430) has an active research site in Duarte, CA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Relapsed or Refractory B-cell Non-Hodgkin's Lymphoma Treatment Options in Duarte, CA

If you're searching for relapsed or refractory b-cell non-hodgkin's lymphoma treatment options in Duarte, CA, this clinical trial (NCT05370430) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Duarte research site is actively enrolling participants for this clinical trial. You'll receive care from experienced relapsed or refractory b-cell non-hodgkin's lymphoma specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all relapsed or refractory b-cell non-hodgkin's lymphoma clinical trials near you to find additional studies recruiting in your area.

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