Minneapolis, MNNCT05471960Now EnrollingIRB Ready

REM Sleep Behavior Disorder Clinical Trial in Minneapolis, MN

Access cutting-edge rem sleep behavior disorder treatment through this clinical trial at a research site in Minneapolis. Study-provided care at no cost to qualified participants.

Sponsored by University of Minnesota

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Expert Care in Minneapolis

Access rem sleep behavior disorder specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related rem sleep behavior disorder treatment provided free

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Check if you qualify for this rem sleep behavior disorder clinical trial in Minneapolis, MN

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Minneapolis

    Convenient for MN residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Minneapolis site if eligible
  4. 4Begin participation

About This REM Sleep Behavior Disorder Study in Minneapolis

REM sleep behavior disorder is a parasomnia that reflects the presence of alpha-synucleinopathy in the brain and is highly predictive of eventual phenoconversion to Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy over the course of years to decades. Neuroplastic adaptations in the brain during the prodromal stage of disease are thought to mask the expression of motor and non-motor signs and may substantially delay diagnosis during a potentially critical time window. This study will examine the state and progression (over 30 to 36 months) of neuroplastic changes in the excitability of the motor and prefrontal cortex (using transcranial magnetic stimulation), the structural and functional connectivity of the brain (using highfield, 7T, magnetic resonance imaging), and the relationship of these changes to the expression of motor and neuropsychological signs, in a cohort of individuals with REM sleep behavior disorder and matched controls.

Sponsor: University of Minnesota

Who Can Participate

Inclusion Criteria

for the iRBD Group:
Diagnosis of polysomnogram-confirmed isolated iRBD.
Able to ambulate independently without the use of an assistive device (e.g., cane) for 50 meters.
Age: 21-75 years. Inclusion Criteria For Control Subject Group:
Age: 21-75 years.
Able to ambulate independently without the use of an assistive device (e.g., cane or walker for 50 meters.

Exclusion Criteria

for iRBD group:
Dementia diagnosis and/or a University of California Brief Assessment of Capacity to Consent (UBACC) score and MacCAT-CR score indicating impaired capacity to consent.
History of musculoskeletal disorders that significant affect movement of lower or upper limbs as determined at the time of enrollment.
Other significant neurological disorders that may affect participation or performance in the study.
Anti-depressant associated RBD. Individuals will be excluded if their dream enactment emerged or clearly worsened after initiating an antidepressant medication.
Meet criteria for overt Parkinson's disease, dementia with Lewy bodies, Multiple Systems Atrophy, Alzheimer's disease, or other neurodegenerative disorder, or other known cause of RBD (e.g., narcolepsy and drug induced RBD).
Untreated sleep-disordered breathing
History of musculoskeletal disorders that significantly affect movement of lower or upper limbs as determined at the time of enrollment.
Pregnant women
Additional exclusion criteria for TMS experiments (note that individuals who are excluded from the TMS experiment still have the opportunity to participate in the other data collection sessions):
History of seizures, epilepsy, stroke, multiple sclerosis, or traumatic brain injury
Recent history of frequent syncope (fainting) episodes in response to blood, emotional stress, or sensory triggers.
Intracranial metallic or magnetic devices (e.g. cochlear implant, deep brain stimulator)
Pacemaker or any implanted device
History of surgery on blood vessels, brain, or heart
Unexplained, recurring headaches or concussion within the last six months
Severe hearing impairment
If participant is taking one of the following medications that affects neuroplasticity testing, they will be excluded from the TMS experiment: haloperidol (dopamine antagonist), prazosin (norepinephrine antagonist), biperiden (acetylcholine antagonist), dopamine modulators, NMDA receptor and calcium channel modulators, GABAergic drugs (benzodiazepines), lithium, lovastatin, and cannabis. Exclusion Criteria for Control subject Group:
Same as exclusion criteria as the iRBD group
History of dream enactment from either patient report or from a bed partner witness that may suggest iRBD.
History of untreated sleep-disordered breathing.
Presence of parkinsonism or cognitive impairment (including dementia or mild cognitive impairment).
Active central nervous system, systemic, psychiatric conditions or use of psychoactive medication that would adversely affect cognitive, neuropsychiatric, motor, or autonomic functioning

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Minneapolis?

Yes, this clinical trial (NCT05471960) has an active research site in Minneapolis, MN that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

REM Sleep Behavior Disorder Treatment Options in Minneapolis, MN

If you're searching for rem sleep behavior disorder treatment options in Minneapolis, MN, this clinical trial (NCT05471960) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Minneapolis research site is actively enrolling participants for this clinical trial. You'll receive care from experienced rem sleep behavior disorder specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all rem sleep behavior disorder clinical trials near you to find additional studies recruiting in your area.

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