Iowa City, IANCT03858777Now EnrollingIRB Ready

Sarcoidosis With Myocarditis Clinical Trial in Iowa City, IA

Access cutting-edge sarcoidosis with myocarditis treatment through this clinical trial at a research site in Iowa City. Study-provided care at no cost to qualified participants.

Sponsored by Nabeel Hamzeh

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Expert Care in Iowa City

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IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related sarcoidosis with myocarditis treatment provided free

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Check if you qualify for this sarcoidosis with myocarditis clinical trial in Iowa City, IA

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Why Participate?

  • No-Cost Study Care

  • Local to Iowa City

    Convenient for IA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Iowa City site if eligible
  4. 4Begin participation

About This Sarcoidosis With Myocarditis Study in Iowa City

Sarcoidosis is a multisystem granulomatous disease of unknown cause that can affect any organ in the body, including the heart. Granulomatous myocarditis can lead to ventricular dysfunction and ventricular arrhythmias causing significant morbidity and mortality. Immunosuppressive therapy (IST) has been shown to reverse active myocarditis and preserve left ventricular (LV) function and in some cases improve LV function. In addition, IST can suppress arrhythmias that develop due to active myocarditis and prevent the formation of scar. The potential role of cardiac biomarkers, including brain natriuretic peptide (BNP), atrial natriuretic peptide (ANP), and cardiac troponins, in detecting active myocarditis is limited and studies have been disappointing. At present, there are no biomarkers to detect active myocarditis and the use of advanced imaging modalities (FDG-PET) for assessing and monitoring active myocarditis is not feasible or practical and is associate with high radiation exposure. As such, a biomarker that is reflective of active myocarditis and that is cardiac specific will assist physicians in assessing the presence of active myocarditis to guide therapeutic decisions and to assess response to therapy which can limit further cardiac damage. Cell free DNA (cfDNA) are fragments of genomic DNA that are released into the circulation from dying or damaged cells. It is a powerful diagnostic tool in cancer, transplant rejection and fetal medicine especially when the genomic source differs from the host. A novel technique that relies on tissue unique CpG methylation patterns can identify the tissue source of cell free DNA in an individual reflecting potential tissue injury. We will be conducting a pilot study to explore the utility of this diagnostic tool to identify granulomatous myocarditis in patients with sarcoidosis.

Sponsor: Nabeel Hamzeh

Who Can Participate

Inclusion Criteria

Diagnosis of sarcoidosis based on the ATS/ERS criteria.
Normal 12 lead ECG within the past one year.
Non-smoker.
No immunosuppressive therapy for at least one year. *

Exclusion Criteria

Known cardiac disease.
Active smoker.
On immunosuppressive therapy.
Sarcoidosis patients with evidence of active myocarditis:
Diagnosis of sarcoidosis based on the ATS/ERS criteria.
Evidence of active myocarditis based on recent cMRI or cFDG-PET.
Non-smoker.
Known cardiac disease other than sarcoidosis.
Active smoker.
On immunosuppressive therapy.
Acute ST elevation myocardial infarction (STEMI):
Diagnosis STEMI based on 1mm ST elevation in 2 or more contiguous leads.
Symptom onset within 12 hours.
Undergoing cardiac intervention for acute coronary syndrome.
Able to consent for blood draw.
Active smoker.
Hemodynamically unstable.
Healthy controls:
No known cardiac disease.
No known cardiovascular risk factors: hypertension, diabetes.
Non-smoker.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Iowa City?

Yes, this clinical trial (NCT03858777) has an active research site in Iowa City, IA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Sarcoidosis With Myocarditis Treatment Options in Iowa City, IA

If you're searching for sarcoidosis with myocarditis treatment options in Iowa City, IA, this clinical trial (NCT03858777) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Iowa City research site is actively enrolling participants for this clinical trial. You'll receive care from experienced sarcoidosis with myocarditis specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all sarcoidosis with myocarditis clinical trials near you to find additional studies recruiting in your area.

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