NCT06779617 · University of Maryland, Baltimore
UMMS Sepsis Early Prediction Score (SEPSys) and RESCUE Score Combined Clinical Trial
What this study is about
This study is designed to test two new risk scores - one designed to predict a patient's four-hour risk of developing sepsis and one designed to predict a patient's four-hour risk of deterioration (cardiac arrest, death, unplanned ICU transfer, or rapid response team call).
View original scientific description
This study is designed to test two new risk scores - one designed to predict a patient's four-hour risk of developing sepsis and one designed to predict a patient's four-hour risk of deterioration (cardiac arrest, death, unplanned ICU transfer, or rapid response team call). The goal of this study is to improve provider awareness of a patient's risk of these two negative outcomes by providing them with new risk scores. The primary outcome will be the time from when the risk score becomes elevated to when vital signs such as heart rate or blood pressure are measured, suggesting an increased awareness.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Units are part of a member hospital of the University of Maryland Medical System (UMMS)
- Units treat inpatient patients
- Units agree to participate in the study General Encounter Inclusion Criteria:
- Encounter is on a participating inpatient unit
- Encounter is associated with a bedded patient in the hospital
- Encounter is associated with an adult (at least 18 years of age at time of admission) Additional SEPSys Encounter Inclusion Criteria: • Encounter has a SEPSys Score Additional RESCUE Encounter Inclusion Criteria: • Encounter has a RESCUE Score
Exclusion criteria
- Hospital Unit Exclusion Criteria:
- Unit treats exclusively outpatients or is located in an outpatient setting
- Unit treats primarily or exclusively pediatric patients (patients under the age of 18 years old)
- Unit treats exclusively psychiatric patients Additional SEPSys Encounter Exclusion Criteria:
- Encounter is with OB for a normal delivery and the patient has yet to give birth. This encounter can become eligible once the patient has given birth.
- Encounter is admitted with a diagnosis of sepsis
- Sepsis was already diagnosed during the encounter This encounter will have been eligible until the patient began showing clinical signs or symptoms of sepsis or received a diagnosis of sepsis. Once they have a diagnosis or clinical signs or symptoms of sepsis, their SEPSys Score will no longer be updated. Data will continue to be collected on time of laboratory orders and treatments. Additional RESCUE Encounter Exclusion Criteria: • Encounter is admitted with a high RESCUE Score (RESCUE Score of 4)
Where
- Baltimore, Maryland
- Bel Air, Maryland
- Easton, Maryland
- Glen Burnie, Maryland
- La Plata, Maryland
- Largo, Maryland
- Towson, Maryland
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced May 5, 2026 · Source of record for eligibility and locations