Recruiting Studies
Advanced SearchData: ClinicalTrials.gov · Source of record for eligibility and locations
Top Cities for Sepsis Clinical Trials
Sepsis clinical trials are recruiting across 66 cities. Here are the cities with the most active studies:
Sepsis Trial Phases
33 research organizations are sponsoring sepsis trials.
About Sepsis
Sepsis is a life-threatening condition that arises when the body's response to an infection damages its own tissues and organs. It can rapidly progress to septic shock and multi-organ failure. Treatment requires urgent antibiotics, IV fluids, and intensive care support.
Clinical trials are advancing new treatments for sepsis. Currently, 42 studies are recruiting a combined 320,039 participants across the United States. Research is being conducted by 33 organizations including University of Maryland, Baltimore, Children's Hospital of Philadelphia, University of California, Berkeley and 30 others.
2026 Sepsis Research Landscape
As of July 2026, the sepsis clinical trial landscape includes 42 actively recruiting studies across 66 cities in the United States. These studies are collectively seeking 320,039 participants, with an average enrollment target of 7,620 per study.
The research spans multiple phases of development: 11 studies are in NA, 5 studies are in PHASE2, 3 studies are in PHASE3, 3 studies are in PHASE4, 1 study is in PHASE1. The presence of Phase 3 trials indicates that some sepsis treatments are in late-stage testing and may be approaching regulatory review.
Research is being led by 33 different organizations, including University of Maryland, Baltimore, Children's Hospital of Philadelphia, University of California, Berkeley, Columbia University, Intermountain Health Care, Inc., and 28 others. The large number of sponsors reflects significant research interest and investment in sepsis treatment advancement.
Geographically, sepsis trials are most concentrated in Boston, Massachusetts (7 trials); Gainesville, Florida (6 trials); Baltimore, Maryland (5 trials); San Francisco, California (4 trials); Rochester, Minnesota (4 trials) and 7 other cities.
Featured Sepsis Studies
Highlighted recruiting studies for sepsis, selected by enrollment size and research scope.
UMMS Sepsis Early Prediction Score (SEPSys) and RESCUE Score Combined Clinical Trial
This study is designed to test two new risk scores - one designed to predict a patient's four-hour risk of developing sepsis and one designed to predict a patient's four-hour risk of deterioration (cardiac arrest, death, unplanned ICU transfer, or rapid response team call). The goal of this study is to improve provider awareness of a patient's risk of these two negative outcomes by providing them ...
Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis
The goal of this quasi-experimental interventional study is to determine the effectiveness of a multifaceted stewardship intervention in reducing overall vancomycin use in five tertiary care Pediatric Intensive Care Units (PICU). There are two groups of subjects in this study: PICU clinicians/sepsis stakeholders and patients admitted to one of the participating PICUs during the study period. The ...
Clean Trial - Chlorination to Reduce Enteric and Antibiotic Resistant Infections in Neonates
The CLEAN (ChLorine to reduce Enteric and Antibiotic resistant infections in Neonates) cluster randomized controlled trial in western Kenya will evaluate the impact of a multi-component chlorination intervention in health care facilities on maternal and neonatal health. Intervention facilities will receive a passive chlorination technology for water supply treatment and a reliable supply of sodium...
Frequently Asked Questions About Sepsis Clinical Trials
Are there sepsis clinical trials near me?
Yes, there are 42 sepsis clinical trials currently recruiting across 66+ cities in the United States, including Boston, Massachusetts; Gainesville, Florida; Baltimore, Maryland. Browse the studies above to find one at a location convenient for you.
How do I join a sepsis clinical trial?
To join a sepsis clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are sepsis clinical trials free?
Yes, participation in sepsis clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of sepsis treatments are being studied?
Current sepsis clinical trials are testing a range of approaches across NA (11 studies), PHASE2 (5 studies), PHASE3 (3 studies), PHASE4 (3 studies), PHASE1 (1 study). These include new drugs, combination therapies, medical devices, and other interventions sponsored by 33 research organizations.
Is it safe to participate in sepsis clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated July 18, 2026 from ClinicalTrials.gov
About This Data
Data: ClinicalTrials.gov · Source of record for eligibility and locations
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated July 18, 2026 · Data from ClinicalTrials.gov