Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis
The objectives of this multicenter pragmatic clinical trial are to compare the effectiveness and relative safety of balanced fluid resuscitation versus 0.9% "normal" saline in children with septic sho...
Stress Hydrocortisone In Pediatric Septic Shock
SHIPSS is a multi-institutional, prospective, controlled, randomized, double-blinded interventional trial that will examine the potential benefits and risks of adjunctive hydrocortisone prescribed for...
Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS
The TRIPS study is a prospective, multi-center, double-blind, adaptively randomized, placebo-controlled clinical trial of the drug anakinra for reversal of moderate to severe hyperinflammation in chil...
Phase 2b Study to Investigate the Safety and Efficacy of TIN816 in Sepsis-associated Acute Kidney Injury (CLEAR-AKI)
The purpose of this Ph2b study is to characterize the dose-response relationship and to evaluate the safety and efficacy of three different single doses of TIN816 in hospitalized adult participants in...
Senolytics To slOw Progression of Sepsis (STOP-Sepsis) Trial
The long-term goal is to test the clinical efficacy of senolytic therapies to reduce progression to and severity of sepsis in older patients. The central hypothesis is that a threshold burden of SnCs ...
Nasal Antisepsis for C. Auris Prevention
This is a randomized, controlled, open-label trial of effect of 10% povidone iodine intranasal antisepsis on the detection of Candida auris....
A Study of REGN7544 for the Treatment in Adult Patients With Sepsis-Induced Hypotension
This study is researching an experimental drug called REGN7544 (called "study drug"). The study is focused on adult patients (18 to 85 years) hospitalized due to a serious infection (called "sepsis") ...
A Phase III, Open Label, Randomized, Controlled Study of VBI-S in the Treatment of Hypovolemia in Patients With Septic Shock (VBI-S-02)
This study is being conducted to evaluate the safety and effectiveness of VBI-S in elevating the blood pressure of septic shock patients with absolute or relative hypovolemia....
Top Cities for Sepsis Clinical Trials
Sepsis clinical trials are recruiting across 49 cities. Here are the cities with the most active studies:
About Sepsis
Sepsis is a life-threatening condition that arises when the body's response to an infection damages its own tissues and organs. It can rapidly progress to septic shock and multi-organ failure. Treatment requires urgent antibiotics, IV fluids, and intensive care support.
Clinical trials are advancing new treatments for sepsis. Currently, 8 studies are recruiting a combined 10,582 participants across the United States. Research is being conducted by 8 organizations including Children's Hospital of Philadelphia, Jerry Zimmerman, Nationwide Children's Hospital and 5 others.
2026 Sepsis Research Landscape
As of March 2026, the sepsis clinical trial landscape includes 8 actively recruiting studies across 49 cities in the United States. These studies are collectively seeking 10,582 participants, with an average enrollment target of 1,323 per study.
Research is being led by 8 different organizations, including Children's Hospital of Philadelphia, Jerry Zimmerman, Nationwide Children's Hospital, Novartis Pharmaceuticals, University of Minnesota, and 3 others.
Geographically, sepsis trials are most concentrated in Boston, Massachusetts (5 trials); San Francisco, California (4 trials); Chicago, Illinois (4 trials); Los Angeles, California (3 trials); Iowa City, Iowa (3 trials) and 7 other cities.
Featured Sepsis Studies
Highlighted recruiting studies for sepsis, selected by enrollment size and research scope.
Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis
The objectives of this multicenter pragmatic clinical trial are to compare the effectiveness and relative safety of balanced fluid resuscitation versus 0.9% "normal" saline in children with septic shock, including whether balanced fluid resuscitation can reduce progression of kidney injury.
Stress Hydrocortisone In Pediatric Septic Shock
SHIPSS is a multi-institutional, prospective, controlled, randomized, double-blinded interventional trial that will examine the potential benefits and risks of adjunctive hydrocortisone prescribed for children with fluid and vasoactive-inotropic refractory septic shock. It is hypothesized that adjunctive hydrocortisone will significantly reduce the incidence of new and progressive organ dysfuncti...
Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS
The TRIPS study is a prospective, multi-center, double-blind, adaptively randomized, placebo-controlled clinical trial of the drug anakinra for reversal of moderate to severe hyperinflammation in children with sepsis-induced multiple organ dysfunction syndrome (MODS).
Frequently Asked Questions About Sepsis Clinical Trials
Are there sepsis clinical trials near me?
Yes, there are 8 sepsis clinical trials currently recruiting across 49+ cities in the United States, including Boston, Massachusetts; San Francisco, California; Chicago, Illinois. Browse the studies above to find one at a location convenient for you.
How do I join a sepsis clinical trial?
To join a sepsis clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are sepsis clinical trials free?
Yes, participation in sepsis clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of sepsis treatments are being studied?
Current sepsis clinical trials are testing a range of approaches. These include new drugs, combination therapies, medical devices, and other interventions sponsored by 8 research organizations.
Is it safe to participate in sepsis clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated March 1, 2026 from ClinicalTrials.gov
About This Data
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated March 1, 2026 · Data from ClinicalTrials.gov