Long-term Follow-up Study to Evaluate Durability of Treatment Response in Previous Bepirovirsen Study Participants (B-Sure)
This is a global multi-center, long-term follow-up study to assess durability of efficacy, as measured by maintenance of treatment response from the parent study, in participants who participated in a...
A Study Evaluating the Efficacy and Safety of ALG-000184 Compared With Tenofovir Disoproxil Fumarate in Untreated HBeAg-Positive and HBeAg- Negative Adult Subjects With Chronic Hepatitis B (B-SUPREME)
This is a Phase 2 study to evaluate efficacy and safety of 48 weeks of oral once daily monotherapy with ALG-000184 versus tenofovir disproxil fumarate (TDF) for chronic HBV infection....
Study of Bepirovirsen in Participants Living With Human Immunodeficiency Virus and Chronic Hepatitis B Virus Infection (B-Focus)
This study will evaluate the efficacy and safety of bepirovirsen compared to placebo in participants with human immunodeficiency virus (HIV)/hepatitis B virus (HBV) co-infection....
A Study of SCG101 in the Treatment of Subjects With Hepatitis B Virus-Related Hepatocellular Carcinoma
This Phase 1/ 2a study is a multicenter study to evaluate the safety, tolerability and efficacy of SCG101 in subjects with hepatitis B virus-related hepatocellular carcinoma...
Top Cities for Hepatitis B Clinical Trials
Hepatitis B clinical trials are recruiting across 31 cities. Here are the cities with the most active studies:
About Hepatitis B
Hepatitis B is a liver infection caused by the hepatitis B virus that can become chronic and lead to cirrhosis, liver failure, or liver cancer. A vaccine can prevent infection. Treatment for chronic hepatitis B includes antiviral medications that suppress the virus.
Clinical trials are advancing new treatments for hepatitis b. Currently, 4 studies are recruiting a combined 846 participants across the United States. Research is being conducted by 3 organizations including GlaxoSmithKline, Aligos Therapeutics, SCG Cell Therapy Pte. Ltd..
2026 Hepatitis B Research Landscape
As of March 2026, the hepatitis b clinical trial landscape includes 4 actively recruiting studies across 31 cities in the United States. These studies are collectively seeking 846 participants, with an average enrollment target of 212 per study.
Research is being led by 3 different organizations, including GlaxoSmithKline, Aligos Therapeutics, SCG Cell Therapy Pte. Ltd..
Geographically, hepatitis b trials are most concentrated in Buenos Aires, (3 trials); New York, New York (2 trials); Hong Kong, (2 trials); Singapore, (2 trials); Sacramento, California (1 trial) and 7 other cities.
Featured Hepatitis B Studies
Highlighted recruiting studies for hepatitis b, selected by enrollment size and research scope.
Long-term Follow-up Study to Evaluate Durability of Treatment Response in Previous Bepirovirsen Study Participants (B-Sure)
This is a global multi-center, long-term follow-up study to assess durability of efficacy, as measured by maintenance of treatment response from the parent study, in participants who participated in a previous bepirovirsen study and achieved a complete or partial response. Eligible participants will be enrolled in this study after completing the end of study (EoS) visit in the respective parent be...
A Study Evaluating the Efficacy and Safety of ALG-000184 Compared With Tenofovir Disoproxil Fumarate in Untreated HBeAg-Positive and HBeAg- Negative Adult Subjects With Chronic Hepatitis B (B-SUPREME)
This is a Phase 2 study to evaluate efficacy and safety of 48 weeks of oral once daily monotherapy with ALG-000184 versus tenofovir disproxil fumarate (TDF) for chronic HBV infection.
Study of Bepirovirsen in Participants Living With Human Immunodeficiency Virus and Chronic Hepatitis B Virus Infection (B-Focus)
This study will evaluate the efficacy and safety of bepirovirsen compared to placebo in participants with human immunodeficiency virus (HIV)/hepatitis B virus (HBV) co-infection.
Frequently Asked Questions About Hepatitis B Clinical Trials
Are there hepatitis b clinical trials near me?
Yes, there are 4 hepatitis b clinical trials currently recruiting across 31+ cities in the United States, including Buenos Aires, ; New York, New York; Hong Kong, . Browse the studies above to find one at a location convenient for you.
How do I join a hepatitis b clinical trial?
To join a hepatitis b clinical trial: 1) Browse the available studies on this page, 2) Click on a study that interests you, 3) Check the study locations to find a site near you, 4) Review the eligibility criteria, and 5) Contact the study site or complete the eligibility form. The process is free and you can withdraw at any time.
Are hepatitis b clinical trials free?
Yes, participation in hepatitis b clinical trials is free. Study-related treatments, medical tests, and doctor visits are provided at no cost to participants. Many studies also offer compensation for your time and travel expenses.
What types of hepatitis b treatments are being studied?
Current hepatitis b clinical trials are testing a range of approaches. These include new drugs, combination therapies, medical devices, and other interventions sponsored by 3 research organizations.
Is it safe to participate in hepatitis b clinical trials?
Clinical trials are carefully regulated by the FDA and institutional review boards (IRBs). All trials must follow strict safety protocols, and participants receive close medical monitoring throughout the study. You can withdraw from a trial at any time without penalty.
Data updated March 1, 2026 from ClinicalTrials.gov
About This Data
Clinical trial information on this page is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health (NIH) and National Library of Medicine (NLM). Study data is refreshed every hour to ensure accuracy.
Medical Disclaimer: The information provided on this page is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making decisions about clinical trial participation or changes to your treatment plan.
Page reviewed by the HelloStudys Research Team · Last updated March 1, 2026 · Data from ClinicalTrials.gov