Houston, TXNCT05889650Now EnrollingIRB Ready

Severe Traumatic Brain Injury Clinical Trial in Houston, TX

Access cutting-edge severe traumatic brain injury treatment through this clinical trial at a research site in Houston. Study-provided care at no cost to qualified participants.

Sponsored by Brain Trauma Foundation

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Expert Care in Houston

Access severe traumatic brain injury specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related severe traumatic brain injury treatment provided free

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Check if you qualify for this severe traumatic brain injury clinical trial in Houston, TX

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Houston

    Convenient for TX residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Houston site if eligible
  4. 4Begin participation

About This Severe Traumatic Brain Injury Study in Houston

The goal of this phase 1 randomized controlled safety and feasibility clinical trial are to determine the safety of external lumbar drainage (ELD) in select patients with severe Traumatic Brain Injury (TBI). The main questions it aims to answer are (i) if ELD is feasible and (ii) safe to perform in severe TBI patients who have radiological evidence of patent basal cisterns and midline shift \<5mm without increasing the risk of neurological worsening or cerebral herniation. All participants will receive routine usual care. The study group will additionally have ELD for cerebrospinal fluid (CSF) drainage. A comparison will be made between the usual treatment plus ELD (interventional) groups, and the usual treatment (control) groups on incidence rate of neurological worsening or cerebral herniation events, and whether total hours with raised intracranial pressure (ICP) are different.

Sponsor: Brain Trauma Foundation

Who Can Participate

Inclusion Criteria

18-65 years age
Glasgow Coma Scale (GCS) 3-8
Pupils symmetric and bilaterally reactive
Midline shift ≤5mm at the level of foramen of Monro on admission or post-operative brain CT
Patent (complete or partial) quadrigeminal cisterns on admission or post-operative brain CT
First randomization and intervention may be commenced within 24 hours of injury
ELD safety score ≥5

Exclusion Criteria

Cisterns on CT completely effaced
Midline shift on CT \>5mm
GCS 3 with dilated and fixed pupils
Uncal or tonsillar herniation on admission or post-operative brain CT
Temporal lobe contusions with effaced ipsilateral cisterns
Penetrating TBI
Primary hemicraniectomy
Patients previously lacking capacity to consent or refuse treatment, or with advanced directives to forego aggressive care
Pre-existing conditions affecting functional status or life expectancy to less than 1 year
Contra-indications for ELD placement: coagulopathy, use of anticoagulants or anti-thrombotics, thrombocytopenia \<50,000, or severe spinal deformity.
posterior fossa hemorrhage

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Houston?

Yes, this clinical trial (NCT05889650) has an active research site in Houston, TX that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Severe Traumatic Brain Injury Treatment Options in Houston, TX

If you're searching for severe traumatic brain injury treatment options in Houston, TX, this clinical trial (NCT05889650) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Houston research site is actively enrolling participants for this clinical trial. You'll receive care from experienced severe traumatic brain injury specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all severe traumatic brain injury clinical trials near you to find additional studies recruiting in your area.

More Traumatic Brain Injury Trials in Houston, TX

See all traumatic brain injury clinical trials recruiting in Houston — not just this study.

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Secure · Expert Care · Houston, TX