La Jolla, CANCT05219110Now EnrollingIRB Ready

Shiga Toxin-Producing Escherichia Coli (E. Coli) Infection Clinical Trial in La Jolla, CA

Access cutting-edge shiga toxin-producing escherichia coli (e. coli) infection treatment through this clinical trial at a research site in La Jolla. Study-provided care at no cost to qualified participants.

Sponsored by University of Calgary

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Expert Care in La Jolla

Access shiga toxin-producing escherichia coli (e. coli) infection specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related shiga toxin-producing escherichia coli (e. coli) infection treatment provided free

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Check if you qualify for this shiga toxin-producing escherichia coli (e. coli) infection clinical trial in La Jolla, CA

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Why Participate?

  • No-Cost Study Care

  • Local to La Jolla

    Convenient for CA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit La Jolla site if eligible
  4. 4Begin participation

About This Shiga Toxin-Producing Escherichia Coli (E. Coli) Infection Study in La Jolla

The objective of this study is to determine if early high volume intravenous fluid administration (hyperhydration) may be effective in mitigating or preventing complications of shiga toxin-producing E. coli (STEC) infection in children and adolescents when compared with traditional approaches (conservative fluid management).

Sponsor: University of Calgary

Who Can Participate

Inclusion Criteria

In order to be eligible to participate in this study (i.e., to be enrolled in the relevant institutional clinical care pathway), an individual must meet all of the following criteria:
Aged 9.0 months to \<21 years at the time of informed consent.
Evidence of high-risk STEC infecting pathogen defined by any of the following:
Bloody diarrhea within the preceding 7 days
Positive STEC culture OR
Positive antigen/polymerase chain reaction test for toxin/gene type not otherwise specified OR
Bloody or Non-bloody diarrhea within the preceding 7 days •Presumptive diagnosis of HUS
(meeting all 3 HUS criteria - anemia, thrombocytopenia, and renal insufficiency) OR
Non-bloody or no diarrhea
Positive STEC culture for high-risk strain (i.e., O103, O104, O111, O113, O121, O145 or O157) OR
Positive antigen/polymerase chain reaction test Stx2 toxin/gene

Exclusion Criteria

All individuals meeting any of the exclusion criteria at baseline will be excluded from study participation.
Presence of Advanced HUS defined by:
Hematocrit \<30% AND
Platelet count \<150 x 103/mm3 AND
Creatinine \> 2.0 mg/dL (177 µmol/L)
The presence of only 1 or 2 of these criteria will not result in patient exclusion, regardless of how close the 3rd criterion is to meeting the exclusion criteria.
Prior episode of HUS or diagnosis of atypical HUS.
Chronic disease limiting fluid volumes administered (e.g. impaired renal, liver, or cardiac function, chronic lung disease).
Evidence of anuria (i.e., no urine output for \> 24 hours).
Hypoxemia requiring oxygen therapy
Hypertensive emergency
Greater than or equal to 10 days since onset of diarrhea or if no diarrhea then the onset of other symptoms.
Patients with known pregnancy
Patients or caregivers with language barriers impairing appropriate conduct of the study protocol.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in La Jolla?

Yes, this clinical trial (NCT05219110) has an active research site in La Jolla, CA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Shiga Toxin-Producing Escherichia Coli (E. Coli) Infection Treatment Options in La Jolla, CA

If you're searching for shiga toxin-producing escherichia coli (e. coli) infection treatment options in La Jolla, CA, this clinical trial (NCT05219110) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our La Jolla research site is actively enrolling participants for this clinical trial. You'll receive care from experienced shiga toxin-producing escherichia coli (e. coli) infection specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all shiga toxin-producing escherichia coli (e. coli) infection clinical trials near you to find additional studies recruiting in your area.

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