NCT03767426 · Beth Israel Deaconess Medical Center
The Effect of Sleep Deprivation and Recovery Sleep on Emotional Memory and Affective Reactivity
What this study is about
To further understand the impact of acute sleep deprivation and recovery sleep on the processing of emotional information the investigators will address and attempt to answer three questions, (i) how both undisturbed sleep and sleep deprivation affect the processing and retrieval of emotional information, (ii) what neural and psychophysiological mechanisms are associated with these behavioral effects, and (iii) to explore the ability of recovery sleep to reverse the effects of sleep deprivation. Together, these studies will provide a greater breadth and depth of knowledge concerning sleep's role in emotion processing and regulation. Given the growing societal tendency to view sleep as unproductive-foregoing it to lengthen work days and increase social opportunities- such knowledge would be of practical importance for understanding the role of sleep in healthy emotional functioning, particular for individuals experiencing periods of increased stress and emotional distress (e.g., new parents, hospital staff, or combat troops).
View original scientific description
To further understand the impact of acute sleep deprivation and recovery sleep on the processing of emotional information the investigators will address and attempt to answer three questions, (i) how both undisturbed sleep and sleep deprivation affect the processing and retrieval of emotional information, (ii) what neural and psychophysiological mechanisms are associated with these behavioral effects, and (iii) to explore the ability of recovery sleep to reverse the effects of sleep deprivation. Together, these studies will provide a greater breadth and depth of knowledge concerning sleep's role in emotion processing and regulation. Given the growing societal tendency to view sleep as unproductive-foregoing it to lengthen work days and increase social opportunities- such knowledge would be of practical importance for understanding the role of sleep in healthy emotional functioning, particular for individuals experiencing periods of increased stress and emotional distress (e.g., new parents, hospital staff, or combat troops).
Interventions
BEHAVIORAL
Sleep Deprivation
Subjects are sleep deprived for an entire night
BEHAVIORAL
Daytime nap
After a night of sleep deprivation, participants will be given a 2 hour nap opportunity
Primary outcome measures
Morphed Face Accuracy and Intensity
Time frame: 1-24 hours
Participants are asked to identify and rate emotional intensity of ambiguous emotional faces (happy, sad, angry) that have been morphed with neutral faces. Scores for each emotional domain will be calculated as (i) accuracy score (number of faces correctly identified over total faces seen), and (ii) average emotional intensity rating. Task will be completed at baseline, post-sleep/sleep deprivation, and post-nap/no nap, and within-subject comparisons will determine how interventions impact emotional perception.
Emotional Memory Tradeoff Memory Score
Time frame: 12-24 hours
Following sleep or sleep deprivation, participants will complete emotional memory tradeoff recognition task at two time points, separated by a nap or wakefulness. Corrected hit rate will be calculated for negative and neutral scene components as the percentage of correctly identified "old" objects/backgrounds minus percentage of false alarms ("new" pictures marked as "old")
Psychomotor vigilance task lapse rate
Time frame: 1-24 hours
The absolute number of trials in a 5-min test period on which the participant fails to responds with 500ms is calculated as the lapse rate.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- willing and able to follow the protocol
- willing and able to meet inclusion criteria for fMRI scanning
- willing to refrain from alcohol and recreational drugs for the duration of the protocol
- normal or corrected to normal vision is required
Exclusion criteria
- self-reported sleep disturbances
- left-handedness or ambidexterity
- a history of mental illness or neurological disorder
- the use of any drugs that could affect either sleep or cognitive functioning (e.g., sleeping pills or antidepressants)
Where
- Boston, Massachusetts
Collaborators
Boston College
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Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Aug 6, 2024 · Source of record for eligibility and locations