Is NCT05775627 recruiting in Portland, OR?

Yes, NCT05775627 is currently recruiting participants at its Portland, OR location. This sleep deprivation clinical trial is actively enrolling qualified participants.

How do I join the sleep deprivation clinical trial in Portland?

To join this clinical trial in Portland, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Portland clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Sleep Deprivation Clinical Trial in Portland, OR

About This Sleep Deprivation Study in Portland

The goal of this study is to uncover sleep and circadian mechanisms contributing to adverse metabolic health. The protocol is a 21 day (7 outpatient days, 14 inpatient days) mechanistic randomized-crossover study designed to identify the impact of chronic sleep restriction and circadian timing, independently and in combination on energy metabolism and identify the independent and combined effects on glucose tolerance.

Sponsor: Oregon Health and Science University

Who Can Participate

Inclusion Criteria

Between 18 and 40 years of age

Established disease-free status

Exclusion Criteria

Dietary restrictions Participants must not have dietary restrictions that could systematically bias their macronutrient intake. The following will exclude participants from enrolling in the study based on their diet:

Participants who choose not to or cannot consume dairy products (milk, yogurt, cheese, ice cream)

Body Composition A body mass index (BMI) of 18.5\< \[BMI\] \< 25 kg/m2 and a waist circumference \<94/80cm.

Psychiatric/psychological suitability Each participant will undergo a structured interview (Mini International Neuropsychiatric Interview) with a qualified OHSU physician. This physician will supervise the administration and scoring of a Beck Depression Inventory II (BDI-II) questionnaire for each potential participant. The following will exclude individuals from participating based on their psychiatric or psychological evaluation:

Individuals with evidence of psychopathology on the BDI-II, or in a structured clinical interview with the physician

A history of severe psychiatric illnesses

Drug dependency

Major depression

Manic depressive illness

Schizophrenic disorders

Panic disorder

Generalized anxiety disorder

Post-traumatic stress disorder

Agoraphobia

Claustrophobia

Paranoid personality disorder

Schizoid personality disorder

Schizotypal personality disorder

Borderline personality disorder

Antisocial personality disorder.

History of using antidepressant medication

History of using neuroleptic medication

History of using tranquilizers

Drug/alcohol use Volunteers must be drug-free (including caffeine, nicotine, alcohol and herbal medications) for the entire duration of the outpatient and in-laboratory study period, with no history of drug or alcohol dependency. All participants must be:

Current non-smokers, and are required to have a history of less than 5 'pack years' of smoking

Medication/drug use Volunteers must not be taking any prescribed medications or over the counter medications, with an exception for birth control.

Prior shift work For stability of endogenous circadian rhythmicity, volunteers must have no history of the following 1 year prior to the study:

Working irregular day and night hours

Regular night work

Rotating shift work f

Not have traveled more than 1 time zone during 3 months prior to the study

Chronobiologic and sleep disorders

Hypernychthemeral sleep/wake cycle

Delayed sleep phase syndrome (wake time \> 2 hours later than desired or habitually after 10:00 AM)

Advanced sleep phase syndrome (wake time \> 2 h earlier than desired or habitually before 5:00 AM)

Sleep apnea (apnea index \>15)

Insomnia (sleep complaint by history or polygraphically recorded sleep efficiency \< 80%)

Hypersomnia

Periodic Limb Movement (PLMS) (PLMS index \>15)

Nocturnal Paroxysmal Dystonia

REM-sleep behavior disorder

Nocturnal Enuresis; (self-report and first night in the laboratory)

Obstructive sleep apnea (apnea/hypopnea index \>5/h as determined by at-home monitoring)

The investigators will also exclude individuals with extreme chronotype using the Horne-Ostberg Morningness/Eveningness questionnaire (i.e., the Owl/Lark Questionnaire)

Diseases of the Cardiovascular System

Hypertension (systolic blood pressure \> 140 or diastolic blood pressure \> 90)

Heart failure

Cardiomyopathy

Cor pulmonale

Ischemic heart disease

Valvular heart disease

History of heart transplantation

Cardiac tumors

Pericardial disease

Metabolic Syndrome Following American Heart Association cutoffs, participants who have, in addition to abdominal fat (obese exclusion criteria), two or more of these factors will be excluded from the study:

HDL cholesterol of less than 40 mg/dL in men or less than 50 mg/dL in women

Systolic blood pressure \>135 mmHg or diastolic blood pressure \>85 mmHg

Fasting blood glucose ≥ 100 mg/dL

Triglycerides ≥ 150 mg/dL

Pre-Diabetes/Diabetes For participants who have a fasting blood glucose level of ≥ 100 mg/dL the investigators will measure hemoglobin A1c to exclude for diabetes (HbA1c\>5.7%).

Hypertension An upper cut off of 140/90 mmHg during an office blood pressure measure will be used as an exclusion criterion. After 5 minutes of rest in a seated position, blood pressure will be measured 3 times, taken 1 minute apart. The average will be used to confirm eligibility criteria. Current or history of beta blocker use will also be exclusionary.

Disorders of the Respiratory System

Cystic fibroses

Chronic bronchitis

Airway obstruction

Interstitial lung diseases

Pulmonary hypertension

Lung neoplasms

Disorders of the Kidney and Urinary Tract

Acute or chronic renal failure

History of renal transplantation

Tubulointerstitial diseases of the kidney

Urinary tract obstruction

Tumors of the urinary tract

Infectious Diseases

Infective endocarditis

HIV infection

Sexually transmitted diseases \[e.g., syphilis (including congenital syphilis and its sequelae), gonorrhea\],

Urinary tract infection

Osteomyelitis

Brucellosis

Toxoplasmosis,

Tuberculosis

Leptospirosis

Lyme disease

Mononucleosis

Parasitic infections such as malaria, toxoplasmosis, giardiasis, schistosomiasis, leishmaniasis

Disorders of the Gastrointestinal System

Esophagitis

Peptic ulcer and gastritis

Neoplasms of the esophagus, stomach or bowel

Disorders of absorption

Inflammatory bowel disease

Diseases of the small and large intestine

Acute appendicitis

Cirrhosis or neoplasms of the liver

History of liver transplantation

Diseases of the gallbladder and bile ducts

Pancreatic disease

Disorders of the Immune System, Connective Tissue and Joints

Systemic lupus erythematosus

Rheumatoid arthritis

Scleroderma

Ankylosing spondylitis

Sarcoidosis

Disorders of the Hematopoietic System

Myeloproliferative diseases

History of bone marrow transplantation

Neoplastic Diseases

Any other neoplastic diseases

Endocrine and Metabolic Diseases

Thyroid disease

Addison's Disease

Cushing's Syndrome

Aldosteronism

Hypoaldosteronism

Pheochromocytoma

Disorders of sexual differentiation that require hormone supplementation that may alter body weight

Disorders of neuroendocrine regulation

Diseases of the anterior pituitary and hypothalamus

Hemochromatosis porphyria

Wilson's Disease

Glycogen storage diseases

Diseases of the parathyroid gland

Metabolic bone disease

Disorders of phosphorus or magnesium metabolism

Paget's Disease

Neurologic Disorders

Epilepsy and disorders of consciousness

Amnesic disorders

Neoplastic diseases of the central nervous system

Demyelinating diseases

Parkinson's Disease

Muscular dystrophy

Myasthenia gravis

Periodic paralysis

Dermatomyositis

Polymyositis

Infections of the nervous system

History of transient ischemic attacks

Hydrocephalus

Tumors of the pituitary gland

Intervertebral disc disease

Gilles de la Tourette Syndrome

Huntington's Disease

Tardive dyskinesia

History of recurrent migraine headaches

Neuromuscular disease.

Subjects must not be currently participating in another research study that would influence their safe participation in our study. Subjects must not be participating in a research study in which they do the following:

Ingest experimental medication

Give blood samples

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Portland?

Yes, this clinical trial (NCT05775627) has an active research site in Portland, OR that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Sleep Deprivation Treatment Options in Portland, OR

If you're searching for sleep deprivation treatment options in Portland, OR, this clinical trial (NCT05775627) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Portland research site is actively enrolling participants for this clinical trial. You'll receive care from experienced sleep deprivation specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all sleep deprivation clinical trials near you to find additional studies recruiting in your area.

Sleep Deprivation Clinical Trial in Portland, OR

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