Is NCT07476287 recruiting in Irvine, CA?

Yes, NCT07476287 is currently recruiting participants at its Irvine, CA location. This small cell lung cancer clinical trial is actively enrolling qualified participants.

How do I join the small cell lung cancer clinical trial in Irvine?

To join this clinical trial in Irvine, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Irvine clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Small Cell Lung Cancer Clinical Trial in Irvine, CA

About This Small Cell Lung Cancer Study in Irvine

This study is being done to learn more about a new medicine called PF-08634404. The study team wants to understand how well PF-08634404 works when given alone or with chemotherapy . Chemotherapy is a type of cancer treatment that uses medicines to destroy cancer cells or stop them from growing. The study is for adults with Transformed Small Cell Lung Cancer (T-SCLC ). T SCLC is a rare lung cancer that happens when one type of lung cancer changes into a more aggressive type after treatment stops working. To join the study, participants must meet the following conditions: * Are aged 18 years or older * Diagnosed with T-SCLC and have not received treatment for this type of lung cancer (a single cycle of chemotherapy may be permitted) * Prior diagnosis of epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer treated with tyrosine kinase inhibitors (TKIs) * Have healthy organs based on medical tests and are in good physical condition After joining the study, adults will be given chemotherapy in addition to the study medicine. After this combination treatment is finished, the study medicine will be continued alone. Adults will receive the treatment through IV infusions (medicine given directly into a vein). All treatments will be done at clinical study sites, where a trained medical team will monitor adults during and after each visit.

Sponsor: Pfizer

Who Can Participate

Inclusion Criteria

Male or female participants aged ≥18 years at the time of informed consent.

Histologically or cytologically confirmed T-SCLC. Participant must have had a prior diagnosis of NSCLC with EGFR mutation which transformed to SCLC following the treatment with TKI(s).

Participants have not received systemic therapy for T-SCLC.

Have at least one measurable lesion as the target lesion based on RECIST v1.1.

Have sufficient tumor tissue from the diagnosis of transformed SCLC available.

Eastern Cooperative Oncology Group performance status of 0 or 1.

Have a minimum life expectancy of \>12 weeks.

Clinical laboratory values at screening within acceptable limits, as defined in the protocol, including: 1) Hematology, 2) Liver function and 3) Renal function.

Exclusion Criteria

Participants are excluded from the study if any of the following criteria apply:

Active or untreated CNS disease, including brain, brainstem, spinal cord, or meningeal metastases. Participants with definitively treated, clinically stable brain metastases may be eligible per protocol criteria. Participants with untreated asymptomatic brain metastases of longest diameter \<1 cm are permitted if all of the following criteria are met: absence of neurological symptoms, no need for corticosteroids, and brain metastasis has no evidence of edema or hemorrhagic features.

Leptomeningeal disease

Clinically significant risk of hemorrhage or fistula, including tumor necrosis/cavitation, invasion or compression of major blood vessels, airways, or critical organs, or risk of tracheoesophageal or pleuroesophageal fistula

History of another malignancy (other than NSCLC) within 3 years prior to first dose, except for malignancies with negligible risk of metastasis or death (eg, adequately treated carcinoma in situ, nonmelanoma skin cancer)

Unresolved toxicity from prior anti-tumor therapy that has not recovered to Grade ≤1 per NCI CTCAE v5.0 (except alopecia or irreversible toxicities deemed stable)

History of allogeneic organ or hematopoietic stem cell transplantation

Active autoimmune disease requiring systemic treatment within the past 2 years (Stable replacement therapy and selected low-risk autoimmune conditions are permitted per protocol)

Interstitial lung disease (ILD), pneumonitis, or significant pulmonary disease, including:

Prior or current non-infectious pneumonitis requiring systemic therapy

DLCO \<50% predicted

Severe asthma, COPD, pulmonary embolism, or autoimmune lung involvement

Uncontrolled or clinically significant cardiovascular, cerebrovascular, metabolic, hepatic, or renal disease within 6 months prior to first dose

Baseline QTcF \>480 msec

Major surgery or severe trauma within 4 weeks prior to first dose, or planned major surgery during the study

Clinically significant pleural effusion, pericardial effusion, or ascites requiring repeated drainage

History of significant bleeding disorders or recent major bleeding events

Clinically significant gastrointestinal conditions, including recent perforation, fistula, obstruction, or active bleeding

Active, uncontrolled, or symptomatic infection, including:

Active hepatitis B or C

Uncontrolled HIV infection

History of immunodeficiency

Severe hypersensitivity or allergic reactions to study intervention components or monoclonal antibodies

Psychiatric illness or medical condition, including recent suicidal ideation or behavior, that may increase risk or interfere with study participation

Prior anti-angiogenic therapy or other prohibited anti-tumor or immunomodulatory therapies per protocol-specified washout periods

Use of prohibited concomitant medications, including high-dose systemic corticosteroids, certain anticoagulants, or live vaccines within protocol-specified timeframes

Recent participation in another investigational study (within 30 days or 5 half-lives, whichever is longer)

Pregnant or breastfeeding participants, or unwillingness to comply with contraception requirements

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Irvine?

Yes, this clinical trial (NCT07476287) has an active research site in Irvine, CA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Small Cell Lung Cancer Treatment Options in Irvine, CA

If you're searching for small cell lung cancer treatment options in Irvine, CA, this clinical trial (NCT07476287) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Irvine research site is actively enrolling participants for this clinical trial. You'll receive care from experienced small cell lung cancer specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all small cell lung cancer clinical trials near you to find additional studies recruiting in your area.

Small Cell Lung Cancer Clinical Trial in Irvine, CA

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