Morgantown, WVNCT06228235Now EnrollingIRB Ready

Smoking Reduction Clinical Trial in Morgantown, WV

Access cutting-edge smoking reduction treatment through this clinical trial at a research site in Morgantown. Study-provided care at no cost to qualified participants.

Sponsored by West Virginia University

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Expert Care in Morgantown

Access smoking reduction specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related smoking reduction treatment provided free

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Why Participate?

  • No-Cost Study Care

  • Local to Morgantown

    Convenient for WV residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Morgantown site if eligible
  4. 4Begin participation

About This Smoking Reduction Study in Morgantown

The objective of this pilot clinical trial is to test the effects of different types of thinking strategies at the time of repetitive Transcranial Magnetic Stimulation (rTMS), applied to the left Dorsolateral Prefrontal Cortex (DLPFC), on smoking craving and brain activity. Participants will be individuals with moderate to high smoking dependence (smoking at least 8 cigarettes a day) who have no intention of quitting in the next 3 months and are eligible to have rTMS and functional magnetic resonance imaging (fMRI). The main objectives of the trial are: 1. To compare the craving-reducing effects of "upregulation" and "downregulation" of craving while looking at pictures related to cigarette smoking during rTMS versus no regulation of craving while looking at neutral pictures unrelated to smoking. 'Upregulation" is thinking about the immediate positive experience of smoking. "Downregulation" is thinking about the long-term negative consequences of smoking. 2. To examine changes in brain activity that accompany craving reductions produced by rTMS paired with upregulation and downregulation of craving while looking at pictures related to cigarette smoking versus no regulation of craving while looking at neutral pictures unrelated to smoking. Following screening for eligibility, participants will be trained on how to do upregulation and downregulation of craving. The participants will then participate in 3 testing sessions. In each session, the participants will receive rTMS at 20Hz in 50 trains (2000 pulses total), followed immediately by fMRI. Sessions will take place 1-2 weeks apart and will differ in the type of thinking strategy participants will use while looking at pictures during the rTMS: * upregulation of craving while viewing smoking-related images * downregulation of craving while viewing smoking-related images * no regulation of craving while viewing neutral smoking-unrelated images The order of sessions will be randomized across participants.

Sponsor: West Virginia University

Who Can Participate

Inclusion Criteria

Able to provide written informed consent, and to follow study procedures
Active cigarette smoker consuming at least 8 cigarettes a day for at least 6 months.
Dual use of cigarettes and e-cigarettes is permitted.

Exclusion Criteria

History of epilepsy or seizure disorder
History of cerebral vascular accident or cortical stroke
History of brain lesions (such as multiple sclerosis, tumor)
History of moderate or severe traumatic brain injury
Possible DSM-5 Axis-I disorders as suggested by scores on the DSM-5 Self-Rated Level 1 Cross-Cutting Symptom Measure (41) exceeding any domain thresholds set by ratings of 2 or higher on individual item, with two exceptions. 1) For depression and anxiety, item scores of 3 or higher will be exclusionary. 2) For substance use (except nicotine/ tobacco and alcohol), item scores of 1 or higher will be exclusionary. For alcohol, the item score of 2 or higher will be the exclusionary.
Active suicidal ideation as assessed by the Columbia Suicide Severity Rating Scale (C-SSRS)
Positive urine toxicology for recreational drugs of abuse
Shoulder-to-shoulder width of \> 60cm (24'') to ensure fit in the MRI scanner
Positive responses to the TMS Screening Form or the MRI checklist that preclude participation at the discretion of the investigator
Intracranial metallic objects (excluding dental fillings)
Prior rTMS treatment
Current treatment with varenicline or nicotine replacement therapy (NRT)
A score of \> 6 on the Readiness to Quit Ladder (42) for smoking
Intake of one or a combination of the following drugs presenting a 'Strong Potential Hazard' for application of rTMS due to their significant seizure threshold lowering potential:
Imipramine, Amitriptyline, Doxepine, Nortriptyline, Maprotiline, Chlorpromazine, Clozapine, Foscarnet, Ganciclovir, Ritonavir, Amphetamines, Cocaine (MDMA, ecstasy), Phencyclidine (PCP, angel's dust), Ketamine, Gamma-hydroxybutyrate (GHB), Alcohol, Theophylline.
The urine toxicology panel will verify the presence of some of these drugs prior to each rTMS session
Recent withdrawal from one of the following drugs representing a 'Strong Relative Hazard' for application of rTMS due to the resulting significant seizure threshold lowering potential:
Alcohol, Barbiturates, Benzodiazepines, Meprobamate, Chloral hydrate

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Morgantown?

Yes, this clinical trial (NCT06228235) has an active research site in Morgantown, WV that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Smoking Reduction Treatment Options in Morgantown, WV

If you're searching for smoking reduction treatment options in Morgantown, WV, this clinical trial (NCT06228235) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Morgantown research site is actively enrolling participants for this clinical trial. You'll receive care from experienced smoking reduction specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all smoking reduction clinical trials near you to find additional studies recruiting in your area.

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