NCT07030257 · Tasca Therapeutics
Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors
What this study is about
The goal of this clinical trial is to learn if an experimental drug CP-383 works to treat advanced cancer. It will also learn about the safety of CP-383.
View original scientific description
The goal of this clinical trial is to learn if an investigational drug CP-383 works to treat advanced cancer. It will also learn about the safety of CP-383. The main questions if aims to answer are: * Does CP-383 slow or stop the growth of cancer in patients with advanced cancer * What medical problems do participants have when taking CP-383 Researchers will test CP-383 in all kinds of cancers at various dose levels to determine what the best dose is to study further.
Interventions
DRUG
CP-383
Novel anti-cancer agent inhibiting pyrimidine synthesis in cancer cells
Primary outcome measures
Part 1: Determine the maximum tolerated dose (MTD)
Time frame: 21 days
Determine the MTD of CP-383 in subjects with advanced solid tumors
Part 2: Evaluate the efficacy of CP-383 at the recommended phase 2 dose in selected tumor types
Time frame: From enrollment through study completion, an average of 1 year
Objective response rate assessed by the investigator according to RECIST
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Measurable or non measurable cancer that the research can assess for changes
- Not eligible or able to take existing standard therapies for cancer
- Availability of a part of a tumor for laboratory testing or willing to have a safe biopsy taken from a tumor
- Diagnosed with locally advanced, recurrent or metastatic incurable disease
- Part 1: any solid tumor (with the exception of brain cancer) that has progressed, standard therapy is no longer or has not helped the cancer, or is too toxic and for whom a clinical trial is an option for continued treatment
- Part 1: specific advanced, metastatic tumor types will also be enrolled: colorectal cancer, small cell lung cancer, head and neck cancer, non-small cell lung cancer, pancreatic cancer, bladder cancer - some of these will have a specific gene mutation in the cancer
- Part 1: selected solid tumor cancer types (with the exception of brain cancers) that have a specific gene mutation in the cancer
- Part 2: specifi
Where
- Denver, Colorado
- Orlando, Florida
- Grand Rapids, Michigan
- St Louis, Missouri
- Omaha, Nebraska
- Huntersville, North Carolina
- Cleveland, Ohio
- Maumee, Ohio
- Philadelphia, Pennsylvania
- Dallas, Texas
- San Antonio, Texas
- West Valley City, Utah
And 1 more location — see the full list below.
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Feb 18, 2026 · Source of record for eligibility and locations