Durham, NCNCT06480227Now EnrollingIRB Ready

Stress Urinary Incontinence Clinical Trial in Durham, NC

Access cutting-edge stress urinary incontinence treatment through this clinical trial at a research site in Durham. Study-provided care at no cost to qualified participants.

Sponsored by NICHD Pelvic Floor Disorders Network

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Expert Care in Durham

Access stress urinary incontinence specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related stress urinary incontinence treatment provided free

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Check if you qualify for this stress urinary incontinence clinical trial in Durham, NC

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Durham

    Convenient for NC residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Durham site if eligible
  4. 4Begin participation

About This Stress Urinary Incontinence Study in Durham

This is a multicentered, double-blind, randomized controlled, surgical trial of 358 women with inadequate symptom relief of stress urinary incontinence (SUI) or stress predominant mixed urinary incontinence (MUI) after conservative care. The Primary Aim is to determine the comparative effectiveness (as defined by "much" or "very much" better on PGI-I) of transurethral bulking agent (TBA) \[for 1 or 2 injections in 12 months\] vs. single-incision sling (SIS) 12 months after treatment intervention in women with predominant stress urinary incontinence (SUI).

Sponsor: NICHD Pelvic Floor Disorders Network

Who Can Participate

Inclusion Criteria

Women ≥ 21 years
For \> 3 months, bothersome SUI (response of somewhat, moderately, or quite a bit) without UUI or stress-predominant MUI. For those with equal bother of UUI and SUI, clinician determination that SUI is more severe/significant than UUI is required.
A positive cough stress test on standardized non-invasive testing or urodynamic SUI within the past 18 months.
Normal PVR \< 150 mL
Candidate for either study procedure as determined by treating surgeon
Available for up to 3 years.
Agrees to randomization.

Exclusion Criteria

Anterior/apical vaginal prolapse beyond the hymen (\>0 on POPQ)
Urge-predominant mixed UI despite stable therapy
Advanced UUI/OAB 3rd line therapy treatment within 1 year of enrollment.
Planned hysterectomy, urethral or anterior/apical surgeries s requiring general anesthesia at the time of SUI treatment, during the last 6 months, or planned within the next 12 months.
Malignancy or history of radiation of the pelvis
Pregnant, post-partum, breast feeding or plans for pregnancy within 1 year
Incomplete emptying (PVR \> 150mL)
Prior anti-incontinence procedure
Neurogenic bladder
Unwilling to continue current UUI treatment until completion of primary outcome at 12 months
Prior adverse reaction to synthetic mesh or urethral bulking material
Chronic bladder or pelvic pain conditions (e.g., Interstitial cystitis, painful bladder syndrome, fibromyalgia, chronic pelvic pain, etc.)
Active treatment for SUI with a pessary. For those using a pessary or other SUI support device, a 3-week washout period should occur prior to assessing baseline measures.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Durham?

Yes, this clinical trial (NCT06480227) has an active research site in Durham, NC that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Stress Urinary Incontinence Treatment Options in Durham, NC

If you're searching for stress urinary incontinence treatment options in Durham, NC, this clinical trial (NCT06480227) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Durham research site is actively enrolling participants for this clinical trial. You'll receive care from experienced stress urinary incontinence specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all stress urinary incontinence clinical trials near you to find additional studies recruiting in your area.

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Secure · Expert Care · Durham, NC