NCT06307977 · Hunter College of City University of New York
Couples Motivational Interviewing to Reduce Drug Use and HIV Risk in Vulnerable Male Couples
(CHP)
What this study is about
This study utilizes a randomly assigned controlled trial design to evaluate the effectiveness of couples motivational interviewing (MI) to reduce the frequency and severity of illicit drug use and frequency of HIV transmission risk behavior (TRB). Participants are randomly assigned to one of two conditions: couples MI or standard couples HIV testing and counseling (CHTC).
View original scientific description
This study utilizes a randomized controlled trial design to evaluate the efficacy of couples motivational interviewing (MI) to reduce the frequency and severity of illicit drug use and frequency of HIV transmission risk behavior (TRB). Participants are randomized to one of two conditions: couples MI or standard couples HIV testing and counseling (CHTC).
Interventions
BEHAVIORAL
Couples Health Project
A 3-session, couples motivational Interviewing drug use and HIV risk reduction intervention
Primary outcome measures
Drug use Frequency
Time frame: 9 Months
Number of reported days of illicit drug use (amphetamines, cocaine/crack, GHB, ketamine or ecstasy) reported on quarterly timeline follow-back assessments
Urine assay for drug use
Time frame: 9 Months
Positive urine screen for drug use assessed bi-annually
CAS with casual partners
Time frame: 9 Months
Number of total anal sex acts (insertive and receptive) with casual partners reported on quarterly timeline follow-back assessments in the absence of adequate PrEP coverage
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Have a main partner who is another cisgender male and have been in a relationship for 3 month or longer
- Index participant must be between 18 and 55; Main partner can be any age 18 and older
- One participant must be HIV negative (as confirmed by rapid test)
- One participant must have used at least 1 drug in the past 30 days (cocaine/crack, opiates, misuse of prescription medication, stimulants, psychedelics, ecstasy, ketamine, GHB, amyl nitrite)
- Index participant must have engaged in TRB in the past 30 days- Defined as CAS with a casual partner, or a serodiscordant or non-monogamous main partner
- Live in the United States
- Speak and read English
Exclusion criteria
- Any signs of serious mental illness or cognitive deficit
- Current suicidal/homicidal ideations
- History of IPV with their main partner and safety concerns in the current relationship.
Where
- Detroit, Michigan
- New York, New York
- Charlottesville, Virginia
Collaborators
National Institute on Drug Abuse (NIDA)
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jun 13, 2025 · Source of record for eligibility and locations