New York, NYNCT07295847Now EnrollingIRB Ready

Systemic Sclerosis Clinical Trial in New York, NY

Access cutting-edge systemic sclerosis treatment through this clinical trial at a research site in New York. Study-provided care at no cost to qualified participants.

Sponsored by AstraZeneca

Quick Self-Assessment

See if you qualify for this New York location

Preparing your pre-screening questions…

Expert Care in New York

Access systemic sclerosis specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related systemic sclerosis treatment provided free

Apply for This New York Location

Check if you qualify for this systemic sclerosis clinical trial in New York, NY

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to New York

    Convenient for NY residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit New York site if eligible
  4. 4Begin participation

About This Systemic Sclerosis Study in New York

This trial is a Phase 1b, open-label, multi-center, clinical study of AZD0120, a BCMA/CD19 dual targeting CAR+ T-cell therapy, to evaluate the safety and tolerability in adult participants with systemic sclerosis (SSc), idiopathic inflammatory myopathies (IIM), or difficult-to-treat rheumatoid arthritis (D2T RA).

Sponsor: AstraZeneca

Who Can Participate

Inclusion Criteria

Capable of giving signed informed consent.
Adequate physiological function and reserve at screening.
Able to comply with recommended medication washout period.
Participants who are suitable for the study as determined by medical evaluation and at the discretion of the investigator.
Willingness to remain on/start appropriate, highly effective methods of birth control or other acceptable criteria.

Exclusion Criteria

BMI at screening \< 18 or \> 35kg/m2.
Any prior CAR T exposure.
Unable or unwilling to remain within proximity (\~2 hours travel time) of the administering investigational site for the first 28 days post study drug administration.
Received a bone marrow or solid organ transplant at any time or on an active transplant waiting list.
Received any investigational drug within ≥ 5 half-lives or 4 weeks, whichever is longer, prior to screening.
Has certain heart conditions that could make it unsafe or unsuitable to take part in the study.
Requirement for supplemental oxygen at rest (except at night for sleep apnea) or mechanical ventilation.
Uncontrolled hypertension (\> 160/100 mmHg) or symptomatic hypertension.
Any central nervous system disease that may impact participants safety in the investigator's opinion.
Other concurrent autoimmune or autoinflammatory disease. Certain autoimmune/autoinflammatory diseases may be included after discussion with the medical monitor.
Evidence of clinically significant bleeding or active bleeding conditions within 90 days before screening
History of malignancy or ongoing treatment for prior malignancy. Certain malignancies may be excepted.
Known genetic inborn error of immunity and/or primary immunodeficiency.
Active viral, bacterial, or fungal infection, or any ongoing infection that requires systemic antimicrobial therapy in the 4 weeks prior to screening.
Seropositive for HIV.
Active viral hepatitis are excluded.
Active syphilis, positive for Treponema pallidum antibody.
Vaccinated with live, attenuated vaccine within 4 weeks prior to apheresis or lymphodepletion.
Not up-to-date on vaccinations per local/national health authority or institutional guidelines for immune-compromised individuals.
Known life threatening allergies, hypersensitivity, or intolerance to AZD0120 or its excipients, including dimethyl sulfoxide.
Contraindications or hypersensitivity to fludarabine and cyclophosphamide.
Major surgery, or has surgery planned during the study.
Pregnant, breastfeeding, or planning to become pregnant while enrolled in this study or within 1 year after receiving study treatment (whichever is later).
Plans to father a child while enrolled in this study or within 1 year after receiving study treatment (whichever is later).
Any issue that would impair the ability of the participant to receive or tolerate the planned treatment at the investigational site, to provide informed consent or any condition in the opinion of the investigator, participation would not be in the best interest of the participant. Other protocol-defined eligibility criteria may apply.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in New York?

Yes, this clinical trial (NCT07295847) has an active research site in New York, NY that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Systemic Sclerosis Treatment Options in New York, NY

If you're searching for systemic sclerosis treatment options in New York, NY, this clinical trial (NCT07295847) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our New York research site is actively enrolling participants for this clinical trial. You'll receive care from experienced systemic sclerosis specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all systemic sclerosis clinical trials near you to find additional studies recruiting in your area.

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