NCT07226804 · M.D. Anderson Cancer Center
Nanosecond Pulsed Field Ablation in the Management of Benign Thyroid Nodules
What this study is about
To observe the outcomes of nsPFA therapy to treat benign thyroid nodules.
View original scientific description
To observe the outcomes of nsPFA therapy to treat benign thyroid nodules.
Interventions
OTHER
Questionnaire
patient-reported outcomes questionnaire
Primary outcome measures
Quality-of-life Questionnaire
Time frame: Through study completion; an average of 1 year
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Eligibility Criteria
- Scheduled to undergo ultrasound guided nsPFA as standard of care
- Age 18 to 80 years.
- Capable of providing independent consent.
- Presence of biopsy-confirmed benign thyroid nodule , defined as one of the following:
- Benign FNA X 2 or
- Benign US guided FNA X 1 + benign thyroid nodule ultrasound appearance (TI-RADS 2) or
- Benign FNA X 1 and radiographic/laboratory evidence of functional nature
- Nodule measuring \>2cm in greatest dimension
- Presence of compressive symptoms reasonably attributable to thyroid nodule (i.e. pressure sensation, dysphagia, dysphonia, respiratory distress)
- No abnormal cervical lymph nodes during screening visit . Exclusion Criteria
- Patients considered unsuitable for nsPFA by the treating physician
Exclusion criteria
- Patients considered unsuitable for nsPFA by the treating physician
Where
- Houston, Texas
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jun 1, 2026 · Source of record for eligibility and locations