Denver, CONCT07485803Now EnrollingIRB Ready

Total Knee Arthroplasty Clinical Trial in Denver, CO

Access cutting-edge total knee arthroplasty treatment through this phase 4 clinical trial at a research site in Denver. Study-provided care at no cost to qualified participants.

Sponsored by AdventHealth

Quick Self-Assessment

See if you qualify for this Denver location

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Expert Care in Denver

Access total knee arthroplasty specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related total knee arthroplasty treatment provided free

Apply for This Denver Location

Check if you qualify for this total knee arthroplasty clinical trial in Denver, CO

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Denver

    Convenient for CO residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Denver site if eligible
  4. 4Begin participation

About This Total Knee Arthroplasty Study in Denver

The goal of this study is to determine whether one dose of IV methadone given right before surgery will help patients' pain management after a total knee replacement and reduce the amount of pain medications taken in the weeks after surgery.

Sponsor: AdventHealth

Who Can Participate

Inclusion Criteria

Provision of signed and dated informed consent from
Stated willingness to comply with all study procedures and availability to attend all required visits for the duration of the study.
Unilateral total knee arthroplasty at Colorado Joint Replacement
All individuals will be screened for drug use (opioid use, illicit drug use) at their preoperative appointment
For females of reproductive potential: use of highly effective contraception for at least 1 month prior to screening and agreement to use such a method during study participation.

Exclusion Criteria

Narcotic use in the past 6 weeks
Current or previous history of drug and alcohol abuse
Tobacco use in the previous 90 days
Treatment with another investigational drug
Patients that cannot receive spinal anesthesia
Patients that cannot receive the standardized multimodal pain medications (i.e. Tylenol, gabapentin and meloxicam)'
Patients that are not able to go home after leaving the hospital and require a short-term rehabilitation facility
Obstructive sleep apnea
Morbid obesity (BMI \>40)
Patients with liver disease.
Significant kidney disease - stage 3 CKD or greater
Pregnant or nursing females
Baseline QTc \>480
severe COPD (GOLD 3 or 4)
home oxygen requirement

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Denver?

Yes, this clinical trial (NCT07485803) has an active research site in Denver, CO that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Total Knee Arthroplasty Treatment Options in Denver, CO

If you're searching for total knee arthroplasty treatment options in Denver, CO, this clinical trial (NCT07485803) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Denver research site is actively enrolling participants for this phase 4 clinical trial. You'll receive care from experienced total knee arthroplasty specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all total knee arthroplasty clinical trials near you to find additional studies recruiting in your area.

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Secure · Expert Care · Denver, CO