Chicago, ILNCT07672301Now EnrollingIRB Ready

Total Knee Arthroplasty (TKA) Clinical Trial in Chicago, IL

Access cutting-edge total knee arthroplasty (tka) treatment through this phase 1/2 clinical trial at a research site in Chicago. Study-provided care at no cost to qualified participants.

Sponsored by University of Chicago

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Expert Care in Chicago

Access total knee arthroplasty (tka) specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related total knee arthroplasty (tka) treatment provided free

Apply for This Chicago Location

Check if you qualify for this total knee arthroplasty (tka) clinical trial in Chicago, IL

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Chicago

    Convenient for IL residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Chicago site if eligible
  4. 4Begin participation

About This Total Knee Arthroplasty (TKA) Study in Chicago

The purpose of this study is to compare same-day discharge rates and recovery outcomes across an adult patient population undergoing elective Total Knee Arthroplasty (TKA), and randomized to receive either spinal block anesthesia or Total IntraVenous Anesthesia (TIVA). Primary Aim: assess same-day discharge rates between study arms (TIVA vs spinal). Secondary Aim: Postoperative comparison of recovery during PostOperative Anesthesia Care Unit (PACU) admission, diagnostic assessment scores; outcomes related to cognition, hemodynamic stability, pain, nausea and vomiting; analysis of IntraOperative electroencephalogram (EEG) monitoring metrics, e.g., total suppression time, average Bi-spectral Index monitor (BIS) value, Spectral Edge Frequency (SEF); ability for Physical Therapy (PT) evaluation prior to discharge; longterm-followup (LTFU), hospital readmission, return to surgery, etc.; adverse event (AE) monitoring.

Sponsor: University of Chicago

Who Can Participate

Inclusion Criteria

Adults aged ≥18 years.
Scheduled to undergo elective primary total knee arthroplasty (TKA) or robotic total knee arthroplasty (TKA) at the University of Chicago.
Eligible for same-day discharge (SDD) based on established orthopedic and anesthesia criteria.
Able to provide written informed consent.
The ability to comprehend and complete cognitive assessment surveys and questionnaires.
Consent to receive either Total IntraVenous Anesthesia (TIVA) or Spinal-block Anesthesia in a randomized manner
No contraindication to either TIVA or spinal anesthesia

Exclusion Criteria

Age \<18 years.
Patients undergoing revision TKA or procedures other than elective primary TKA.
Ineligibility for same-day discharge as determined by the surgical or anesthesia team.
Contraindications to either anesthetic technique (e.g., spinal block anesthesia contraindicated due to coagulopathy, infection at puncture site, or patient refusal).
Known allergy or hypersensitivity to study-related medications.
Significant pre-existing cognitive impairment or dementia that would preclude valid participation in Short Portable Mental Status Questionnaire (SPMSQ), and 3-Minute Diagnostic Assessment for Confusion Assessment Method (3D-CAM) assessments.
Severe chronic pain syndromes (e.g., fibromyalgia, centrally mediated pain disorders) that could confound perioperative pain assessment.
Body mass index (BMI) \> 40.
Prisoners or other vulnerable populations unable to provide voluntary consent.
Unable to give appropriate consent or difficult to comprehend and complete cognitive assessment surveys and questionnaires

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Chicago?

Yes, this clinical trial (NCT07672301) has an active research site in Chicago, IL that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Total Knee Arthroplasty (TKA) Treatment Options in Chicago, IL

If you're searching for total knee arthroplasty (tka) treatment options in Chicago, IL, this clinical trial (NCT07672301) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Chicago research site is actively enrolling participants for this phase 1/2 clinical trial. You'll receive care from experienced total knee arthroplasty (tka) specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all total knee arthroplasty (tka) clinical trials near you to find additional studies recruiting in your area.

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