NCT05958342 · Jason Sperry
CAlcium and VAsopressin Following Injury Early Resuscitation (CAVALIER) Trial
(CAVALIER)
What this study is about
The CAlcium and VAsopressin following Injury Early Resuscitation (CAVALIER) Trial is a proposed 4 year, where neither patients nor doctors know which treatment is given, mutli-center, prehospital and early in hospital phase randomly assigned trial designed to determine the effectiveness and safety of prehospital calcium and early in hospital vasopressin in patients at risk of hemorrhagic shock.
View original scientific description
The CAlcium and VAsopressin following Injury Early Resuscitation (CAVALIER) Trial is a proposed 4 year, double-blind, mutli-center, prehospital and early in hospital phase randomized trial designed to determine the efficacy and safety of prehospital calcium and early in hospital vasopressin in patients at risk of hemorrhagic shock.
Interventions
DRUG
Calcium Gluconate
1 gram calcium gluconate provided via intravenous or intraosseous access over approximately 2-5 minutes
DRUG
Vasopressin
4 unit vasopressin bolus followed by vasopressin infusion at 0.04 U/min for eight hours
DRUG
saline placebo
saline placebo volume matched to prehospital or in hospital phase
Primary outcome measures
Number of participants with 30-day mortality
Time frame: from randomization to death or 30 days, whichever comes first
all cause mortality within 30 days
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Prehospital Phase: Injured patients at risk of hemorrhagic shock being transported from scene or referral hospital to a participating CAVALIER trial site who meet the following criteria: 1A. Systolic blood pressure ≤ 90mmHg and tachycardia (HR ≥ 108) at scene, at outside hospital, or during anticipated transport to a participating CAVALIER trial site OR 1B. Systolic blood pressure ≤ 70mmHg at scene, at outside hospital, or during anticipated transport to a participating CAVALIER trial site Early In-Hospital Phase: Injured patients at a participating CAVALIER trial site at risk of hemorrhagic shock who meet the following criteria: 1A. Systolic blood pressure ≤ 90mmHg and tachycardia (HR ≥ 108) at scene, at outside hospital, during transport, or in emergency department of a participating CAVALIER trial site OR 1B. Systolic blood pressure ≤ 70mmHg at scene, at outside hospital, during transport, or in emergency department of a participating CAVALIER trial sit
Where
- Tucson, Arizona
- Little Rock, Arkansas
- San Francisco, California
- Denver, Colorado
- Miami, Florida
- Baltimore, Maryland
- Minneapolis, Minnesota
- Columbia, Missouri
- Albuquerque, New Mexico
- Columbus, Ohio
- Pittsburgh, Pennsylvania
- Lubbock, Texas
And 1 more location — see the full list below.
Collaborators
United States Department of Defense
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jun 3, 2026 · Source of record for eligibility and locations