Nashville, TNNCT06609356Now EnrollingIRB Ready

Type 1 Diabetes Mellitus Clinical Trial in Nashville, TN

Access cutting-edge type 1 diabetes mellitus treatment through this clinical trial at a research site in Nashville. Study-provided care at no cost to qualified participants.

Sponsored by Vanderbilt University Medical Center

Quick Self-Assessment

See if you qualify for this Nashville location

Preparing your pre-screening questions…

Expert Care in Nashville

Access type 1 diabetes mellitus specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related type 1 diabetes mellitus treatment provided free

Apply for This Nashville Location

Check if you qualify for this type 1 diabetes mellitus clinical trial in Nashville, TN

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Nashville

    Convenient for TN residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Nashville site if eligible
  4. 4Begin participation

About This Type 1 Diabetes Mellitus Study in Nashville

This study aims to understand the heart and blood sugar health benefits of using an adjunctive therapy to lower high insulin levels in people with type 1 diabetes. The investigators will also look at people with a specific type of diabetes called Glucokinase-Maturity Onset Diabetes of the Young (GCK-MODY) and those without diabetes to help interpret the results. The investigators will use a medication that helps the body get rid of sugar, called and SGLT2 inhibitor, with the goal to reduce the body's insulin requirements. The investigators believe this could lead to better heart and blood sugar health, including a better response to insulin and more available nitric oxide, a gas that helps blood vessels function well. The investigators will compare heart and blood sugar health risk factors in participants with type 1 diabetes, participants with Glucokinase-Maturity Onset Diabetes of the Young (GCK-MODY), and non-diabetic healthy volunteers under two conditions: high insulin levels typical of type 1 diabetes and normal insulin levels typical of the other two groups.

Sponsor: Vanderbilt University Medical Center

Who Can Participate

Inclusion Criteria

Age: 18-60 years BMI: 18-28 kg/m² Weight: ≥ 50 kg T1DM Participants: Duration of T1DM: 1-30 years HbA1c: 5.7-7.5% Insulin Therapy: Using automated insulin delivery GCK-MODY Participants: HbA1c: 5.7-7.5% Genetic Confirmation: Positive GCK sequencing Control Participants: HbA1c: less than 5.5% \*\*

Exclusion Criteria

Severe Hypoglycemia: ≥1 episode in the past 3 months Comorbidities:
Any hospital admissions for diabetic ketoacidosis in the past 6 months
SBP greater than 140 mmHg and DBP greater than 100 mmHg
eGFR by MDRD equation of less than 60 mL/min/1.73 m²
AST or ALT greater than 2.5 times ULN
Hct less than 35% Medications:
Any antioxidant vitamin supplement within 2 weeks before the study
Any systemic glucocorticoid
Antipsychotics
Atenolol, Metoprolol, Propranolol
Any thiazide diuretic
Any oral contraceptive pill with greater than 35 mcg ethinyl estradiol
Growth hormone
Any immunosuppressant
Antihypertensive
Any antihyperlipidemic Other:
Tanner stage less than 5
Peri- or post-menopausal women
Active smoker T1DM Participants: Medications: Any diabetes medication except insulin C-peptide: greater than 0.7 ng/mL (fasting) GCK-MODY Participants: None specific

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Nashville?

Yes, this clinical trial (NCT06609356) has an active research site in Nashville, TN that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Type 1 Diabetes Mellitus Treatment Options in Nashville, TN

If you're searching for type 1 diabetes mellitus treatment options in Nashville, TN, this clinical trial (NCT06609356) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Nashville research site is actively enrolling participants for this clinical trial. You'll receive care from experienced type 1 diabetes mellitus specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all type 1 diabetes mellitus clinical trials near you to find additional studies recruiting in your area.

More Pulmonary Embolism Trials in Nashville, TN

See all pulmonary embolism clinical trials recruiting in Nashville — not just this study.

Browse Pulmonary Embolism Trials in Nashville

Ready to Join in Nashville?

Take the first step toward participating in this groundbreaking clinical trial

Secure · Expert Care · Nashville, TN