Is NCT07142252 recruiting in Miami, FL?

Yes, NCT07142252 is currently recruiting participants at its Miami, FL location. This type 1 diabetes mellitus clinical trial is actively enrolling qualified participants.

How do I join the type 1 diabetes mellitus clinical trial in Miami?

To join this clinical trial in Miami, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Miami clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Type 1 Diabetes Mellitus Clinical Trial in Miami, FL

About This Type 1 Diabetes Mellitus Study in Miami

This Phase 2 study is a 2-arm, multi-center, double-masked (masking of the participant, care provider and investigator), placebo-controlled, 2:1 randomized trial design in new onset T1D participants (within 100 days of diagnosis). Participants will be administered rezpegaldesleukin/placebo once every 14 days over 26 weeks with an additional 6-month follow-up period.

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Who Can Participate

Inclusion Criteria

Provide informed consent or assent as appropriate and if \< 18 years of age have a parent or legal guardian provide informed consent.

Age ≥ 8 and ≤ 45 years at the time of signing informed consent and (as applicable) assent A.

Diagnosis of T1D within 100 days of randomization.

Positive for at least one islet cell autoantibody; GAD65A, mIAA (if obtained within 10 days of the onset of insulin therapy), IA-2A, ICA, or ZnT8A.

Stimulated C-peptide of ≥ 0.2 pmol/mL measured during MMTT conducted at least 21 days from diagnosis of diabetes.

Participants ≥ 18 years old to have body weight ≥ 35 kg and ≤ 130kg.

Participants \< 18 years old to have body weight \> 5th and \<98th percentile for age and sex.

Willing to comply with intensive diabetes management.

All CMV and/or EBV seronegative participants must be CMV and EBV PCR negative within 30 days of randomization and may not have had signs or symptoms of a CMV or EBV-compatible illness lasting longer than 7 days within 30 days of randomization.

All CMV seropositive participants must be CMV PCR negative and all EBV seropositive participants must have a EBV PCR viral load \< 2,000 IU/mL within 30 days of randomization. All participants may not have had signs or symptoms of a CMV or EBV-compatible illness lasting longer than 7 days within 30 days of randomization.

Must meet "TrialNet Eligibility Minimum Immunization Recommendations" found in Appendix A of the MOO.

Be at least 4 weeks from last live vaccination prior to randomization.

Participants that are not already immunized against the current year's influenza are required to receive non-live influenza vaccination at least 2 weeks prior to randomization when vaccine for the current or upcoming flu season is available.

Be willing to forgo vaccines (other than killed influenza and COVID-19) during the treatment phase and the 3 months after study drug treatment period.

If a female participant with reproductive potential, must be willing to avoid pregnancy (abstinence or highly effective contraceptive method) through the completion of the study and undergo pregnancy testing prior to each study visit.

Males of reproductive age must use an adequate contraceptive method during the treatment phase and for 3 months following the last dose of study drug. A Only adult participants ≥ 18 years old are permitted to be included in the first 18 enrolled participants in this study. Participants ≥ 12 and \< 18 years of age are only permitted to screen for this study if the safety review of the first 18 adult participants is assessed favorably by the TrialNet DSMB in consultation with Nektar Safety Group. Once an additional 17 participants ages 12 to 45, including at least 9 participants aged 12-17, enroll and complete through the 6-month visit and have the safety review assessed favorably by the TrialNet DSMB in consultation with Nektar Safety Group, then the trial is permitted to screen and enroll the remaining 31 enrollees ≥ 8 and ≤ 45 years old. If data at either juncture do not support expansion into the pediatric ages, the trial will enroll the remaining participants to reach the target sample size with the currently approved age thresholds. See protocol sections 2.5 and 3.5 for additional details.

Exclusion Criteria

One or more screening laboratory values as stated

Neutrophils \< 1,500 /μL

Lymphocytes \< 800 /μL

Platelets \< 100,000 /μL

Hemoglobin \< 6.2 mmol/L (10.0 g/dL)

Eosinophils \> 1,000 /μL

Potassium \> 5.5 mmol/L or \< 3.0 mmol/L

Sodium \> 150 mmol/L or \< 130 mmol/L

Estimated Glomerular Filtration Rate (eGFR) \< 60 mL/min/1.73m2

AST or ALT or ALP \> 2 times the upper limit of normal based on lab reference range

Total Bilirubin ≥ 1.5 times upper limit of normal unless diagnosed with Gilbert's syndrome

Serum creatinine \> 2 times the upper limit of normal

Current or ongoing use of non-insulin pharmaceuticals that affect glycemia within 7 days of the screening visit or any prohibited concomitant medication as listed in section 3.7.

Concurrent treatment with systemic immunosuppressive agents (including biologics or steroids) - intranasal and inhaled corticosteroids are permitted as well as eye and ear drops containing corticosteroids.

Have active signs or symptoms of acute infection at the time of randomization.

Active acute or chronic infection requiring medical treatment (antibiotics, antiviral, antifungal) within 4 weeks of baseline visit unless approved by the Infectious Disease Committee.

Have evidence of prior or current tuberculosis infection as assessed by Purified Protein Derivative (PPD), interferon gamma release assay (IGRA) or by history.

Any present malignancies or history of malignancy within the past 5 years, other than a successfully treated nonmelanoma skin cancer.

Be currently pregnant or lactating or anticipate becoming pregnant during the study.

History of severe cardiac disease (i.e. myocardial infarction, unstable ischemic heart disease, cerebrovascular accident, stroke, stage 3 or 4 heart failure).

Have evidence of current or past HIV or Hepatitis B infection.

Have evidence of active Hepatitis C infection.

History of organ allograft.

Hypersensitivity to IL-2, PEG, or any components of the active drug.

Had major surgery within 12 weeks before the screening visit or anticipates requiring major surgery during the study.

Has any autoimmune disease other than T1D, stable thyroid, stable asthma, inactive Graves' disease or celiac disease (e.g., rheumatoid arthritis, polyarticular juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, multiple sclerosis, systemic lupus erythematous) or has any other disease that may be affected by immunotherapy.

Screening 12-lead electrocardiogram (ECG) with findings suggestive/indicative of acute ischemia, clinically important heart disease or clinically important arrhythmias.

Current or history thrombotic events within six months prior to randomization

Known or untreated clinically significant hyperthyroidism or hypothyroidism

Prior treatment within 12 months of randomization with an immune modulating/immune depleting agents, such as teplizumab (TZield), thymoglobulin (ATG) or rituximab.

Prior treatment within 6 months of randomization with a metabolic therapy intended to alter the disease course of T1D (e.g. teplizumab).

Has significant and uncontrolled disease/condition in the investigator's opinion that may adversely affect study participation or may compromise the study results or increase participant risk.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Miami?

Yes, this clinical trial (NCT07142252) has an active research site in Miami, FL that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Type 1 Diabetes Mellitus Treatment Options in Miami, FL

If you're searching for type 1 diabetes mellitus treatment options in Miami, FL, this clinical trial (NCT07142252) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Miami research site is actively enrolling participants for this clinical trial. You'll receive care from experienced type 1 diabetes mellitus specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all type 1 diabetes mellitus clinical trials near you to find additional studies recruiting in your area.

Type 1 Diabetes Mellitus Clinical Trial in Miami, FL

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