Nashville, TNNCT06338553Now EnrollingIRB Ready

Type 1 Diabetes Clinical Trial in Nashville, TN

Access cutting-edge type 1 diabetes treatment through this early phase 1 clinical trial at a research site in Nashville. Study-provided care at no cost to qualified participants.

Sponsored by Vanderbilt University Medical Center

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Expert Care in Nashville

Access type 1 diabetes specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related type 1 diabetes treatment provided free

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Check if you qualify for this type 1 diabetes clinical trial in Nashville, TN

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Nashville

    Convenient for TN residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Nashville site if eligible
  4. 4Begin participation

About This Type 1 Diabetes Study in Nashville

The goal of this study is to determine how a drug class called glucagon-like peptide-1 receptor agonists (GLP-1Ra) affects people during an early stage of Type 1 Diabetes undergoing clinical teplizumab treatment. This study involves giving participants a liquid meal under different conditions and observing how their bodies respond, focusing on blood sugar levels, insulin effectiveness, and blood vessel function. The meal tests are followed by two post-treatment tests, one with the GLP-1Ra drug and the other with a placebo. Each test involves blood draws before and during the meal test, GLP-1Ra or placebo administration, and an ultrasound to measure blood vessel function. The goal is to see if GLP-1Ra can help manage blood sugar levels and improve cardiovascular health in this population.

Sponsor: Vanderbilt University Medical Center

Who Can Participate

Inclusion Criteria

Age: 12-50 years
BMI: 18-31 kg/m2 (adults) or 5-95th %ile (pediatric)
Stage 2 T1DM (i.e., ≥ 2 islet auto-antibodies and:
fasting glucose ≥ 100 mg/dL and \< 126 mg/dL OR
2-hr OGTT /MMTT ≥ 140 mg/dL and \< 200 mg/dL OR
During an OGTT having a glucose of \> 199 mg/dL at 30, 60, or 90 minutes)

Exclusion Criteria

Comorbidities:
SBP \> 140 mmHg and DBP \> 100 mmHg
eGFR by MDRD equation of \< 60 mL/min/1.73m2
AST or ALT \> 2.5 times ULN
Family history of medullary thyroid carcinoma
Diagnosis of pancreatitis or gastroparesis within the past 3 years
Medications: Any diabetes medication, any antioxidant vitamin supplement (\<2 weeks before a study), any systemic glucocorticoid, antipsychotic, atenolol, metoprolol, propranolol, niacin, any thiazide diuretic, any OCP with \> 35 mcg ethinyl estradiol, growth hormone, any immunosuppressant, antihypertensive, any antihyperlipidemic
Other: pregnancy, peri- or post-menopausal women, active smoker Aim 4: Early Stage 3 T1DM with GLP-1Ra Monotherapy Inclusion Criteria
Age: 12-50 years
BMI: 18-31 kg/m2 (adults) or 5-95th %ile (pediatric)
Early stage 3 T1DM with either
HbA1c 6.5% to 8.0% at diagnosis OR
HbA1c 5.7% to 6.4% with oral glucose test meeting ADA criteria for stage 3 T1DM within the past three months prior to or during screening visit
Time of stage 3 diagnosis: within eight weeks of first study visit Exclusion Criteria
DKA history: history of diabetic ketoacidosis requiring hospital admission
Comorbidities:
Family history of medullary thyroid carcinoma
Diagnosis of pancreatitis or gastroparesis within the past 3 years
Medications: Any diabetes medication, any antioxidant vitamin supplement (\<2 weeks before a study), any systemic glucocorticoid, antipsychotic, atenolol, metoprolol, propranolol, niacin, any thiazide diuretic, any OCP with \> 35 mcg ethinyl estradiol, growth hormone, any immunosuppressant, antihypertensive, any antihyperlipidemic
Other: pregnancy, peri- or post-menopausal women, active smoker

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Nashville?

Yes, this clinical trial (NCT06338553) has an active research site in Nashville, TN that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Type 1 Diabetes Treatment Options in Nashville, TN

If you're searching for type 1 diabetes treatment options in Nashville, TN, this clinical trial (NCT06338553) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Nashville research site is actively enrolling participants for this early phase 1 clinical trial. You'll receive care from experienced type 1 diabetes specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all type 1 diabetes clinical trials near you to find additional studies recruiting in your area.

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