Is NCT06676657 recruiting in Portland, OR?

Yes, NCT06676657 is currently recruiting participants at its Portland, OR location. This type 1 diabetes clinical trial is actively enrolling qualified participants.

How do I join the type 1 diabetes clinical trial in Portland?

To join this clinical trial in Portland, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Portland clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Type 1 Diabetes Clinical Trial in Portland, OR

About This Type 1 Diabetes Study in Portland

An artificial pancreas (AP) is a control system for automatic insulin delivery. The investigators have implemented a high blood sugar detection and dosing algorithm for use within an AP control system. If a high blood sugar pattern is detected, correction insulin will be calculated and delivered. The investigators will test how well the new algorithm manages glucose compared to the AP control system without high blood sugar detection and dosing. This type of algorithm may improve glucose control for high risk patient populations.

Sponsor: Oregon Health and Science University

Who Can Participate

Inclusion Criteria

Diagnosis of type 1 diabetes mellitus for at least 1 year.

Male or female participants 18 and older.

HbA1c or GMI ≥ 7.0% at screening.

Physically willing and able to perform 30 min of exercise (as determined by the investigator after reviewing the participant's activity level).

Current use of an FDA-approved hybrid closed loop system for ≥3 months.

Lives with another person age 18 or older who will sleep in the house at night and that can attend the training on using the system.

Lives within 40 miles of OHSU

Total daily insulin requirement is less than 139 units/day.

Able to read, write and understand spoken English

Current use of a smartphone so can be contacted by study staff off-campus.

Willingness to follow all study procedures, including attending all clinic visits.

Willingness to sign informed consent and HIPAA documents.

Exclusion Criteria

GMI or A1c \<6.5% or \>10.5%

Sensor glucose shows \< 2% of time above 250 mg/dl in last 30 days.

Individual of childbearing potential who is pregnant or intending to become pregnant or breast-feeding, or is not using adequate contraceptive methods. Acceptable contraception includes birth control pill / patch / vaginal ring, Depo-Provera, Norplant, an IUD, the double barrier method (the woman uses a diaphragm and spermicide and the man uses a condom), or abstinence.

Any cardiovascular disease, defined as a clinically significant EKG abnormality at the time of screening or any history of: stroke, heart failure, myocardial infarction, angina pectoris, or coronary arterial bypass graft or angioplasty. Diagnosis of 2nd or 3rd degree heart block or any non-physiological arrhythmia judged by the investigator to be exclusionary.

Renal insufficiency (GFR \< 60 ml/min, using the MDRD equation as reported by the OHSU laboratory).

Liver failure, cirrhosis, or any other liver disease that compromises liver function as determined by the investigator.

History of severe hypoglycemia during the past 6 months prior to screening visit or hypoglycemia unawareness as judged by the investigator. Participants will complete a hypoglycemia awareness questionnaire. Participants will be excluded for four or more R responses.

History of diabetes ketoacidosis during the prior 6 months prior to screening visit, as diagnosed on hospital admission or as judged by the investigator.

Adrenal insufficiency.

Any active infection (example skin infection requiring antibiotics)

Known or suspected abuse of alcohol, narcotics, or illicit drugs.

Seizure disorder.

Active foot ulceration.

Peripheral arterial disease.

Major surgical operation within 30 days prior to screening.

Use of an investigational drug within 30 days prior to screening.

Chronic usage of any immunosuppressive medication (such as cyclosporine, azathioprine, sirolimus, or tacrolimus).

Bleeding disorder or platelet count below 50,000.

Allergy to Fiasp insulin

Current administration of oral or parenteral corticosteroids.

Any life threatening disease, including malignant neoplasms and medical history of malignant neoplasms within the past 5 years prior to screening (except basal and squamous cell skin cancer).

Use of beta blockers or non-dihydropyridine calcium channel blockers.

Current use of any medication that can lower glucose other than insulin (ex. Wegovy, Jardiance) with the exception of metformin if dose has been stable for ≥3 months and patient willing to not change dose during study.

Gastroparesis

Diet consisting of less than 50 grams of carbohydrates per day.

A positive response to any of the questions from the Physical Activity Readiness Questionnaire with one exception: participant will not be excluded if he/she takes a single blood pressure medication that doesn't impact heart rate and blood pressure is controlled on the medication (blood pressure is less than 140/90 mmHg).

Any chest discomfort with physical activity, including pain or pressure, or other types of discomfort.

Any clinically significant disease or disorder which in the opinion of the Investigator may jeopardize the participant's safety or compliance with the protocol.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Portland?

Yes, this clinical trial (NCT06676657) has an active research site in Portland, OR that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Type 1 Diabetes Treatment Options in Portland, OR

If you're searching for type 1 diabetes treatment options in Portland, OR, this clinical trial (NCT06676657) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Portland research site is actively enrolling participants for this clinical trial. You'll receive care from experienced type 1 diabetes specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all type 1 diabetes clinical trials near you to find additional studies recruiting in your area.

Type 1 Diabetes Clinical Trial in Portland, OR

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