NCT05179954 · University of Missouri-Columbia
Lipoprotein Kinetics in T1D
(LTD)
What this study is about
The purpose of this research study is to understand how type 1 diabetes (T1D) increases the risk for cardiovascular diseases (heart attack and stroke). To this end, the investigators will compare apolipoprotein and triglyceride kinetics in people wtih T1D and healthy control participants.
View original scientific description
The purpose of this research study is to understand how type 1 diabetes (T1D) increases the risk for cardiovascular diseases (heart attack and stroke). To this end, the investigators will compare apolipoprotein and triglyceride kinetics in people wtih T1D and healthy control participants.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Age: ≥18 but ≤45 years
- premenopausal/eumenorrheic and not pregnant or breastfeeding
- non-obese (body mass index ≥18.5\<30.0 kg/m2)
- Fasting plasma triglyceride \<150 mg/dL Additional inclusion criteria for control subjects:
- Fasting plasma glucose \<100 mg/dL
- Plasma glucose 2 h after a 75 g oral glucose challenge \<140 mg/dL
- HbA1c \<5.6%. Additional inclusion criteria for subjects with T1DM:
- stable insulin regimen (multiple daily insulin injections or continuous subcutaneous insulin) for at least 8 weeks before screening
- no use of diabetes medications other than insulin
- HbA1c \<8.0%, basal (overnight fasted)
- no severe symptomatic hypoglycemic event associated with a seizure or requiring help from other people or a medical facility in the 6 months prior to screening or metabolic testing
Exclusion criteria
- more than 1.5 h of structured exercise/week
- use of tobacco products, excessive amounts of alcohol, or dietary supplements and/or medications known to affect lipid metabolism
- hypothyroidism or other disorders known to affect lipid metabolism
- conditions that would make it impossible to complete the study protocol
Where
- Columbia, Missouri
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Feb 10, 2026 · Source of record for eligibility and locations