Seattle, WANCT07699380Now EnrollingIRB Ready

Type 1 Diabetes (T1D) Clinical Trial in Seattle, WA

Access cutting-edge type 1 diabetes (t1d) treatment through this phase 2 clinical trial at a research site in Seattle. Study-provided care at no cost to qualified participants.

Sponsored by University of Washington

Quick Self-Assessment

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Expert Care in Seattle

Access type 1 diabetes (t1d) specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related type 1 diabetes (t1d) treatment provided free

Apply for This Seattle Location

Check if you qualify for this type 1 diabetes (t1d) clinical trial in Seattle, WA

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Seattle

    Convenient for WA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Seattle site if eligible
  4. 4Begin participation

About This Type 1 Diabetes (T1D) Study in Seattle

The study is a randomized, double-blind, parallel-group clinical trial to examine the effects of 24 weeks of oral AMX0035 (sodium phenylbutyrate + taurursodiol) versus placebo in 60 adults with Type 1 Diabetes (T1D) (n=30 per arm). Enrollment will be distributed equally between the University of Washington and Amsterdam University Medical Center/Diabetes Center Amsterdam. Participants will be recruited through diabetes research registries, local T1D clinics, and community outreach.

Sponsor: University of Washington

Who Can Participate

Inclusion Criteria

Adults ≥18 years to \<70 years of age with established T1D (duration ≥1 year)
Currently on insulin therapy (multiple daily injections or insulin pump)
HbA1c \<9.5%
BMI 18.5-40 kg/m2
On stable dose of RASB or statin, if indicated
Willing and able to comply with all study procedures

Exclusion Criteria

History of pancreatic disease (including pancreatitis) or pancreatic surgery
History of cardiovascular disease or stroke within the past 6 months
History of heart failure per New York Heart Association criteria
History of severe edema or salt restriction requirement
Biliary disease or pathologies that may alter enterohepatic circulation of bile acids
Estimated glomerular filtration rate (eGFR) \<60 mL/min/1.73m²
Liver disease (ALT/AST \>3x upper limit of normal \[ULN\])
Pregnancy, breastfeeding, or planning pregnancy during the study period
Known hypersensitivity to study drug components
Abnormal baseline ECG
Use of off label medications that affect insulin sensitivity within the past 1 month (e.g., metformin, GLP-1RA, SGLT2i, pioglitazone)
Chronic use of anticoagulants
Use of bile acid sequestering agents, inhibitors of bile acid transporters, bile acid derivatives, aluminum-based antacids, probenecid, pan-HDAC inhibitors, phase 2 metabolizing enzymes (e.g., uridine diphosphate glucuronosyl transferases), phase 1 metabolizing enzymes other than cytochrome P450 enzymes (CYPs), and OATP1B3
Use of substrates of CYP1A2, CYP2C8, CYP2B6, CYP3A4, Organic Anion transporter 1, P-glycoprotein, and Breast Cancer Resistance Protein
History of severe hypoglycemia requiring assistance within the past 3 months
History of diabetic ketoacidosis (DKA) within the past 3 months
Personal or family history of breast cancer or ovarian cancer
Current participation in another clinical trial
Any condition(s) found by the study team and confirmed with the Investigator that make it unsafe to participate

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Seattle?

Yes, this clinical trial (NCT07699380) has an active research site in Seattle, WA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Type 1 Diabetes (T1D) Treatment Options in Seattle, WA

If you're searching for type 1 diabetes (t1d) treatment options in Seattle, WA, this clinical trial (NCT07699380) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Seattle research site is actively enrolling participants for this phase 2 clinical trial. You'll receive care from experienced type 1 diabetes (t1d) specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all type 1 diabetes (t1d) clinical trials near you to find additional studies recruiting in your area.

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Secure · Expert Care · Seattle, WA