Houston, TXNCT06466434Now EnrollingIRB Ready

Unresectable Melanoma Clinical Trial in Houston, TX

Access cutting-edge unresectable melanoma treatment through this clinical trial at a research site in Houston. Study-provided care at no cost to qualified participants.

Sponsored by M.D. Anderson Cancer Center

Quick Self-Assessment

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Expert Care in Houston

Access unresectable melanoma specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related unresectable melanoma treatment provided free

Apply for This Houston Location

Check if you qualify for this unresectable melanoma clinical trial in Houston, TX

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Houston

    Convenient for TX residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Houston site if eligible
  4. 4Begin participation

About This Unresectable Melanoma Study in Houston

To learn about the possible effects of a prebiotic food-enriched diet (PreFED) targeting the gut microbiome in participants with melanoma who are starting immune checkpoint blockade (ICB) therapy.

Sponsor: M.D. Anderson Cancer Center

Who Can Participate

Inclusion Criteria

Age ≥18 years old
English-speaking
Body mass index (BMI) 18.5-45 kg/m2
Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
Histologically confirmed stage III/IV, unresectable cutaneous, uveal, acral or mucosal melanoma. Asymptomatic brain metastases are allowed.
Planned initiation of 1st line standard-of-care approved immune checkpoint blockade (anti-PD1 +/- anti-CTLA4 or anti-LAG3 inhibitors or talimogene laherparepvec T-VEC) in the metastatic setting. Prior targeted therapy or ICB in the adjuvant setting is allowed.
Returning to MD Anderson for restaging and follow-up (ICB treatment may occur locally)
Measurable disease per RECIST 1.1 or RANO criteria. Up to 10 patients without measurable can be enrolled.
WOCP must have negative UPT within 1 week of beginning dietary intervention.
Self-reported willingness to eat the provided foods (with some tailoring to their food preferences)
Self-reported willingness to comply with scheduled visits, undergo venipuncture, provide stool samples.

Exclusion Criteria

Previous ICB treatment in the metastatic setting
History of inflammatory bowel disease, total colectomy, or bariatric surgery.
Currently taking steroids \> Prednisone 10 mg/day or equivalent
Medical contraindications to the Intervention Diet as determined by the treating physician.
Self-reported major dietary restrictions, including but not limited to relevant food allergies, celiac disease, or diets such as vegan, ketogenic, extended fasting.
Insulin-dependent diabetes or condition requiring bile acid sequestrants
Unable or unwilling to undergo study procedures.
IV antibiotic use in the past month or oral antibiotic use in past 2 weeks.
Regularly taking supplements containing prebiotics, fiber and/or probiotics, and unable/unwilling to discontinue for the purpose of the study.
Current smoker or heavy drinker (defined as \>14 drinks per week) or current illicit drug use.
Currently pregnant, planning to become pregnant, or lactating.
Concurrent malignancy requiring systemic therapy other than hormonal therapy.
Cognitively impaired adults

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Houston?

Yes, this clinical trial (NCT06466434) has an active research site in Houston, TX that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Unresectable Melanoma Treatment Options in Houston, TX

If you're searching for unresectable melanoma treatment options in Houston, TX, this clinical trial (NCT06466434) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Houston research site is actively enrolling participants for this clinical trial. You'll receive care from experienced unresectable melanoma specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all unresectable melanoma clinical trials near you to find additional studies recruiting in your area.

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