La Jolla, CANCT06409819Now EnrollingIRB Ready

Urinary Tract Infection, Recurrent Clinical Trial in La Jolla, CA

Access cutting-edge urinary tract infection, recurrent treatment through this phase 1/2 clinical trial at a research site in La Jolla. Study-provided care at no cost to qualified participants.

Sponsored by University of California, San Diego

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IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related urinary tract infection, recurrent treatment provided free

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Why Participate?

  • No-Cost Study Care

  • Local to La Jolla

    Convenient for CA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit La Jolla site if eligible
  4. 4Begin participation

About This Urinary Tract Infection, Recurrent Study in La Jolla

This proposal will take an important first step in the study of phage therapy for treatment of recurrent urinary tract infection (rUTI) in female kidney transplant recipients (KTR); a common condition that is associated with increasing multidrug resistance, sickness, loss of kidney function and death. The investigators will conduct a randomized phase I/II pilot clinical trial of targeted phage therapy versus placebo in asymptomatic female KTR with a history of rUTI due to Escherichia coli to assess safety, tolerability, and feasibility of this approach, possible efficacy, and changes in the gut and urinary microbiome during the 180 days of the study. This highly innovative and impactful proposal will provide proof of concept data and also inform the design of a subsequent larger phase III clinical trial of phage therapy for rUTI treatment in KTR and will have broad downstream effects within the fields of infectious diseases and transplantation.

Sponsor: University of California, San Diego

Who Can Participate

Inclusion Criteria

Female kidney transplant recipients, aged 18 and older with a confirmed diagnosis of a history of recurring UTI with E. coli as their typical uropathogen.
Two urine culture proven UTIs in prior 6 months or three in prior 12 months due to E coli. UTI is defined as any change in symptoms from baseline urinary comfort (dysuria, hematuria, abdominal/flank pain, increased urinary frequency) or systemic signs of infection (fever, chills, systemic inflammatory reaction syndrome etc.) associated with a positive urine culture with bacterial growth of ≥104 colony forming units/mL).
Ability to self-administer study drug (or a family member that will do so) and willing to adhere to the phage therapy regimen.
For participants able to become pregnant: use of highly effective contraception for at least 1 month prior to screening and agreement to use such a method during study participation and for an additional 6 months after the end of phage therapy administration.
Provision of signed and dated informed consent form
Stated willingness to comply with all study procedures and availability for the duration of the study.

Exclusion Criteria

Presents with hardware in the urinary tract (e.g. stent, percutaneous nephrostomy, chronic urinary catheter).
Recipient of \>1 kidney transplant.
Recipient of Ileal conduit.
Recipient of surgical neobladder.
Diagnosed with chronic urinary retention requiring self-catheterization.
Anatomic cause for rUTI such as ureteral stenosis.
Within the first 3 months of kidney transplant.
Venous access sites or in whom an existing venous access site needs to be preserved for future need (as per the participant's transplant nephrologist/ surgeon)
Diagnosed with active cytomegalovirus or BK virus infections.
Current pregnancy, actively trying to conceive, or lactating.
Known allergic reactions to phage products.
Prisoners or individuals without decisional capacity.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in La Jolla?

Yes, this clinical trial (NCT06409819) has an active research site in La Jolla, CA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Urinary Tract Infection, Recurrent Treatment Options in La Jolla, CA

If you're searching for urinary tract infection, recurrent treatment options in La Jolla, CA, this clinical trial (NCT06409819) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our La Jolla research site is actively enrolling participants for this phase 1/2 clinical trial. You'll receive care from experienced urinary tract infection, recurrent specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all urinary tract infection, recurrent clinical trials near you to find additional studies recruiting in your area.

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