NCT03513770 · Milton S. Hershey Medical Center
Autonomic Control of the Circulation and VDR
(VDR)
What this study is about
The study objective of this project is to examine the mechanisms of the venous distension reflex (VDR) in humans. We hypothesize that COX blockade with ketorolac tromethamine, an given through a vein (IV) NSAID, will attenuate the muscle sympathetic nerve activity (MSNA) response to limb venous distension.
View original scientific description
The study objective of this project is to examine the mechanisms of the venous distension reflex (VDR) in humans. We hypothesize that COX blockade with ketorolac tromethamine, an intravenous NSAID, will attenuate the muscle sympathetic nerve activity (MSNA) response to limb venous distension. To gain further insight into whether the COX byproducts directly stimulate chemically-sensitive afferents, or enable venodilation and indirectly evoke afferent stimulation, we will measure vein size using 3T MRI during venous distention with and without ketorolac infusions.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Are capable of giving informed consent
- Are any race or ethnicity
- Are fluent in written and spoken English
- Have a satisfactory history and physical exam to meet inclusion/
Exclusion criteria
- Are free of acute or chronic medical conditions
- Are 21 - 35 years of age (inclusive)
- Weigh over 50 kg Exclusion Criteria
- Are less than 21 or over 35 years of age
- Are Pregnant or nursing women
- Are prisoners or institutionalized individuals or unable to consent
- Any chronic diseases (hypertension, heart, lung, neuromuscular disease, kidney disease, diabetes or cancer).
- Are taking medications that may affect their cardiovascular or nervous system
- Has taken an NSAID within 48 hours of any visit (visit will need to be rescheduled)
- Has never taken NSAIDs and therefore would not know if they are allergic to it
- Have a supine BP \>140/90 mmHg
- Have known allergy to ibuprofen-like drugs (NSAIDS) or aspirin
- Have history of asthma or nasal polyps
- Have history of GI bleeding or ulcers
- Subjects with ferromagnetic metal implants
- Subjects who are claustrophobic
Where
- Hershey, Pennsylvania
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jul 9, 2026 · Source of record for eligibility and locations