13 Brain Cancer Clinical Trials in Ann Arbor, MI (2026)

Q: How do I join a clinical trial in Ann Arbor?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Ann Arbor research site will contact you.

Recruiting Brain Cancer Studies in Ann Arbor

NCT05009992Recruiting

Combination Therapy for the Treatment of Diffuse Midline Gliomas

This phase II trial determines if the combination of ONC201 with different drugs, panobinostat or paxalisib, is effective for treating participants with diffuse midline gliomas (DMGs). Despite years o...

Ann Arbor, MIPHASE2360 participantsUniversity of California, San Francisco

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NCT05839379Recruiting

Targeted Pediatric High-Grade Glioma Therapy

The goal of this study is to perform genetic sequencing on brain tumors from children, adolescents, and young adult patients who have been newly diagnosed with a high-grade glioma. This molecular prof...

Ann Arbor, MI350 participantsNationwide Children's Hospital

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NCT04732065Recruiting

ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors

This phase I trial studies the effects and best dose of ONC206 alone or in combination with radiation therapy in treating patients with diffuse midline gliomas that is newly diagnosed or has come back...

Ann Arbor, MIPHASE1208 participantsSabine Mueller, MD, PhD

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NCT04775485Recruiting

A Study to Evaluate Tovorafenib in Pediatric and Young Adult Participants With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors

This is a Phase 2, multi center, open-label study to evaluate the safety and efficacy of Type II RAF (tovorafenib) in pediatric participants with low-grade glioma or advanced solid tumors. Qualifying ...

Ann Arbor, MIPHASE2141 participantsDay One Biopharmaceuticals, Inc.

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NCT05535166Recruiting

Molecular and Clinical Risk-Directed Therapy for Infants and Young Children With Newly Diagnosed Medulloblastoma

This is a multi-center, multinational phase 2 trial that aims to explore the use of molecular and clinical risk-directed therapy in treatment of children 0-4.99 years of age with newly diagnosed medul...

Ann Arbor, MIPHASE2130 participantsSt. Jude Children's Research Hospital

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NCT05843253Recruiting

Study of Ribociclib and Everolimus in HGG and DIPG

The goal of this study is to determine the efficacy of the study drugs ribociclib and everolimus to treat pediatric and young adult patients newly diagnosed with a high-grade glioma (HGG), including D...

Ann Arbor, MIPHASE2120 participantsNationwide Children's Hospital

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NCT05096481Recruiting

PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

This study will address the question of whether targeting CMV antigens with PEP-CMV can serve as a novel immunotherapeutic approach in pediatric patients with newly-diagnosed high-grade glioma (HGG) o...

Ann Arbor, MIPHASE2120 participantsNationwide Children's Hospital

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NCT06319027Recruiting

Identifying Findings on Brain Scans That Could Help Make Better Predictions About Brain Cancer Progression, The GABLE Trial

This phase II trial studies whether different imaging techniques can provide additional and more accurate information than the usual approach for assessing the activity of tumors in patients with newl...

Ann Arbor, MIPHASE2100 participantsECOG-ACRIN Cancer Research Group

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NCT07282587Recruiting

Study of ONC206 (JZP3507) in Advanced Pheochromocytoma and Paraganglioma

This is a two-stage Phase 2 trial evaluating the efficacy and safety of ONC206 in participants with Pheochromocytoma and Paraganglioma (PCPG)....

Ann Arbor, MIPHASE290 participantsJazz Pharmaceuticals

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NCT06838676Recruiting

ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas

This is a Phase II open-label study to investigate the safety and efficacy of ACT001 in patients with DIPG and H3K27-altered HGG....

Ann Arbor, MIPHASE260 participantsNationwide Children's Hospital

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NCT06894979Recruiting

Testing the Addition of an Anti-Cancer Drug, AZD1390, During Radiation Therapy for Newly Diagnosed High Grade Glioma, Diffuse Midline Glioma, or Diffuse Intrinsic Pontine Glioma

This phase I clinical trial studies the side effects and best dose of AZD1390 and to see how well it works when given together with radiation therapy for the treatment of pediatric patients with high ...

Ann Arbor, MIPHASE154 participantsChildren's Oncology Group

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NCT04774718Recruiting

A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Alectinib in Pediatric Participants With ALK Fusion-Positive Solid or CNS Tumors

This study will evaluate the safety, pharmacokinetics, and efficacy of alectinib in children and adolescents with ALK fusion-positive solid or CNS tumors for whom prior treatment has proven to be inef...

Ann Arbor, MIPHASE142 participantsHoffmann-La Roche

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NCT06914479Recruiting

Virus-Based Gene Therapy (AdV-HSV1-TK and AdV-Flt3L) in Combination With Valacyclovir for the Treatment of Pediatric and Young Adult Patients With Resectable, Recurrent Primary Malignant Brain Tumors

This phase I trial tests the safety, side effects and best dose of AdV-HSV1-TK and AdV-Flt3L in combination with valacyclovir for the treatment of patients with primary cancerous (malignant) brain tum...

Ann Arbor, MIPHASE111 participantsUniversity of Michigan Rogel Cancer Center

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About Brain Cancer Clinical Trials in Ann Arbor

Brain cancer includes tumors that originate in the brain (primary) or spread from other areas (metastatic). Glioblastoma (GBM) is the most common and aggressive primary brain tumor. Treatment typically combines surgery, radiation, and chemotherapy, with immunotherapy trials underway.

There are currently 13 brain cancer clinical trials recruiting participants in Ann Arbor, MI. These studies are seeking a combined 1,786 participants. Research is being sponsored by University of California, San Francisco, Nationwide Children's Hospital, Sabine Mueller, MD, PhD and 7 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Brain Cancer Clinical Trials in Ann Arbor — FAQ

Are there brain cancer clinical trials in Ann Arbor?

Yes, there are 13 brain cancer clinical trials currently recruiting in Ann Arbor, MI. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Ann Arbor?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Ann Arbor research site will contact you about next steps.

Are clinical trials in Ann Arbor free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Ann Arbor studies also compensate for your time and travel.

What brain cancer treatments are being tested?

The 13 active trials in Ann Arbor are testing new therapies including novel drugs, biologics, and treatment approaches for brain cancer.

Data updated July 17, 2026 from ClinicalTrials.gov