11 Chronic Lymphocytic Leukemia Clinical Trials in Bethesda, MD (2026)

Q: How do I join a clinical trial in Bethesda?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Bethesda research site will contact you.

Recruiting Chronic Lymphocytic Leukemia Studies in Bethesda

NCT05254743Recruiting

A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

The purpose of Part 1 of this study is to compare the efficacy and safety of pirtobruitinib (LOXO-305) to ibrutinib in participants with CLL/SLL; participants may or may not have already had treatment...

Bethesda, MDPHASE3737 participantsLoxo Oncology, Inc.

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NCT05947851Recruiting

A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010).

The purpose of this study is to assess the safety and tolerability and to confirm the dose of nemtabrutinib in combination with venetoclax in participants with R/R CLL/SLL. The primary study hypothese...

Bethesda, MDPHASE3735 participantsMerck Sharp & Dohme LLC

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NCT05131022Recruiting

A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies

This is a first-in-human Phase 1a/1b multicenter, open-label study designed to evaluate the safety and anti-cancer activity of NX-5948 in patients with advanced B-cell malignancies....

Bethesda, MDPHASE1572 participantsNurix Therapeutics, Inc.

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NCT07509151Recruiting

Surovatamig as Consolidation Therapy in Participants With Chronic Lymphocytic Leukaemia or Small Lymphocytic Lymphoma With Unmutated Immunoglobulin Heavy Chain Variable (IGHV)

The purpose of this study is to evaluate the therapeutic benefit and safety of subcutaneous (SC) Surovatamig monotherapy as consolidation therapy in patients with Chronic Lymphocytic Leukaemia (CLL)/ ...

Bethesda, MDPHASE3420 participantsAstraZeneca

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NCT05645107Recruiting

A Study to Evaluate Efficacy, Safety, and PK of XEMBIFY®+Standard Medical Treatment (SMT) Compared to Placebo+SMT to Prevent Infections in Participants With HGG and Recurrent or Severe Infections Associated With B-cell Chronic Lymphocytic Leukemia, Multiple Myeloma, and Non-Hodgkin Lymphoma

The primary purpose of the study is to evaluate whether biweekly administered XEMBIFY® plus Standard Medical Treatment (SMT) over a one-year period will reduce the rate of major bacterial infections p...

Bethesda, MDPHASE3386 participantsGrifols Therapeutics LLC

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NCT07342478Recruiting

ROCKET-CLL Global Phase 3 Study: Rocbrutinib vs Pirtobrutinib in cBTKi-Pretreated R/R CLL/SLL

This is a Phase 3, randomized, open-label, multicenter study comparing rocbrutinib (LP-168) versus pirtobrutinib in adult participants with relapsed or refractory chronic lymphocytic leukemia (CLL) or...

Bethesda, MDPHASE3306 participantsNewave Pharmaceutical Inc

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NCT06588478Recruiting

A Study Evaluating the Efficacy and Safety of Pirtobrutinib in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

The main purpose of Part 1 of this study is to assess the efficacy and safety of 3 dose levels of Pirtobrutinib in participants with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (S...

Bethesda, MDPHASE2249 participantsLoxo Oncology, Inc.

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NCT04830137Recruiting

A Study of NX-2127 in Adults With Relapsed/Refractory B-cell Malignancies

This is a first-in-human Phase 1a/1b multicenter, open-label oncology study designed to evaluate the safety and anti-cancer activity of NX-2127 in patients with advanced B-cell malignancies....

Bethesda, MDPHASE1248 participantsNurix Therapeutics, Inc.

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NCT05724121Recruiting

Observational Study of Cardiac Arrhythmias During Treatment With BTK Inhibitors or Venetoclax

Background: Bruton s tyrosine kinase inhibitors (BTKi) are used to treat a form of leukemia. But taking BTKi can also increase a person s risk of developing an abnormal heart rhythm. This can cause s...

Bethesda, MD135 participantsNational Heart, Lung, and Blood Institute (NHLBI)

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NCT03986034Recruiting

Early Clonal Dynamics During Venetoclax Treatment for Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL)

Background: The drug venetoclax treats chronic lymphocytic leukemia (CLL). Researchers want to find better treatments for CLL. To do that, they need to learn how the drug affects CLL cancer cells and...

Bethesda, MDPHASE275 participantsNational Heart, Lung, and Blood Institute (NHLBI)

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NCT07428707Recruiting

Immune Profiling of CLL/SLL Treated With First-Line Pirtobrutinib

Background: Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are blood cancers that affect certain white blood cells. Advanced forms of these diseases are difficult to treat. P...

Bethesda, MDEARLY_PHASE130 participantsNational Heart, Lung, and Blood Institute (NHLBI)

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About Chronic Lymphocytic Leukemia Clinical Trials in Bethesda

Chronic lymphocytic leukemia (CLL) is a slow-growing cancer of the blood and bone marrow that affects B lymphocytes. It is the most common type of adult leukemia. Treatment options include targeted therapies, chemotherapy, and immunotherapy.

There are currently 11 chronic lymphocytic leukemia clinical trials recruiting participants in Bethesda, MD. These studies are seeking a combined 3,893 participants. Research is being sponsored by Loxo Oncology, Inc., Merck Sharp & Dohme LLC, Nurix Therapeutics, Inc. and 4 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Chronic Lymphocytic Leukemia Clinical Trials in Bethesda — FAQ

Are there chronic lymphocytic leukemia clinical trials in Bethesda?

Yes, there are 11 chronic lymphocytic leukemia clinical trials currently recruiting in Bethesda, MD. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Bethesda?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Bethesda research site will contact you about next steps.

Are clinical trials in Bethesda free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Bethesda studies also compensate for your time and travel.

What chronic lymphocytic leukemia treatments are being tested?

The 11 active trials in Bethesda are testing new therapies including novel drugs, biologics, and treatment approaches for chronic lymphocytic leukemia.

Data updated October 18, 2026 from ClinicalTrials.gov