34 Multiple Myeloma Clinical Trials in Bethesda, MD (2026)

Q: How do I join a clinical trial in Bethesda?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Bethesda research site will contact you.

Recruiting Multiple Myeloma Studies in Bethesda

NCT00059748Recruiting

Studies of the Natural History, Pathogenesis, and Outcome of Autoinflammatory Diseases Including Juvenile Dermatomyositis

Purpose: The purpose of this protocol is 1. To comprehensively evaluate patients with autoinflammatory diseases clinically, genetically and immunologically at the autoinflammatory disease clinic at t...

Bethesda, MD5,000 participantsNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

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NCT00246857Recruiting

Screening Protocol for Genetic Diseases of Lymphocyte Homeostasis and Programmed Cell Death

This study will determine the biochemical and genetic causes of inherited immune diseases affecting lymphocyte homeostasis. Lymphocytes are a type of white blood cell that fights infections. Normally,...

Bethesda, MD5,000 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT00001355Recruiting

Detection and Characterization of Host Defense Defects

This protocol is designed to evaluate selected patients with documented recurrent or unusual infections and their family members for clinical and laboratory correlates of immune abnormalities. It allo...

Bethesda, MD3,600 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT03610802Recruiting

Send-In Sample Collection to Achieve Genetic and Immunologic Characterization of Primary Immunodeficiencies

Background: The immune system helps the body fight infections. Primary immunodeficiency disorders (PIDs) are diseases that make it easier for people to get sick. Many PIDs are inherited. This means p...

Bethesda, MD3,000 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT03394053Recruiting

The Mechanistic Biology of Primary Immunodeficiency Disorders

Background: Primary immunodeficiency disorders, or PIDs, are diseases that weaken the immune system. This makes it easier for a person to get sick. Some PIDs are mild and may not be diagnosed until l...

Bethesda, MD2,500 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT03000244Recruiting

Long-Term Follow up of Patients Undergoing Hematopoietic Stem Cell Transplantation, Cellular Therapy, or Gene Therapy

Background: People who have had an allogeneic hematopoietic stem cell transplant (HCT), cellular therapy (CT), or gene therapy (GT) have bone marrow or an immune system that is damaged. They get stem...

Bethesda, MD2,000 participantsNational Cancer Institute (NCI)

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NCT00404560Recruiting

Detection and Characterization of Infections and Infection Susceptibility

This screening study will examine the causes of immune disorders affecting white blood cells, which defend against infections and will try to develop better means of diagnosis and treatment of these i...

Bethesda, MD2,000 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT00001184Recruiting

Immune Regulation in Ulcerative Colitis or Crohn s Disease

This study will investigate in patients with Crohn s disease and ulcerative colitis how the body s immune system controls inflammation in the gastrointestinal tract (stomach and intestines)-specifical...

Bethesda, MD1,000 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT05403151Recruiting

Controls and Healthy Vasculature Initiative

Background: Diseases involving blood, blood vessels, and immune systems are leading causes of death in the United States. Researchers studying these diseases need to compare blood samples from both h...

Bethesda, MD1,000 participantsNational Heart, Lung, and Blood Institute (NHLBI)

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NCT00001406Recruiting

Activation and Function of Eosinophils in Conditions With Blood or Tissue Eosinophilia

This study will investigate how, why and under what conditions eosinophils (a type of white blood cell) become activated and will examine their function in immune reactions. Eosinophil counts often ri...

Bethesda, MD800 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT01568697Recruiting

Oral Bacteria and Immune System Problems Involved in Gum Disease (Periodontitis)

Background: \- Gum disease is a condition in which the tissue around the tooth root becomes swollen and infected. This condition can cause tooth loss if it is not treated. Who gets gum disease and ho...

Bethesda, MD700 participantsNational Institute of Dental and Craniofacial Research (NIDCR)

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NCT02682667Recruiting

Biospecimen Procurement for Center for Immuno-Oncology Immunotherapy Protocols

Background: Cancer has a major impact in the United States and across the world. In 2015, over 1.5 million new cases of cancer were diagnosed in the U.S. Researchers want to study samples from people...

Bethesda, MD500 participantsNational Cancer Institute (NCI)

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NCT01132859Recruiting

VRC 900: Evaluation of Tissue-Specific Immune Responses in Adults 18 Years of Age and Older

Background: \- The Vaccine Research Center (VRC) is dedicated to understanding immune responses associated with prevention and treatment of infectious diseases. To study these immune responses, resea...

Bethesda, MD500 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT05738824Recruiting

Natural History of Inflammatory Muscle Diseases

Objective: To collect information and biospecimens (such as blood, muscle, and skin samples) that will be used to research causes and treatments of inflammatory muscle diseases. Eligibility: People...

Bethesda, MD500 participantsNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

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NCT02579967Recruiting

Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary Immunodeficiencies

Background: Allogeneic blood or marrow transplant is when stem cells are taken from one person s blood or bone marrow and given to another person. Researchers think this may help people with immune s...

Bethesda, MDPHASE2354 participantsNational Cancer Institute (NCI)

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NCT06948110Recruiting

Deciphering the Genetic Architecture of Autoimmune Diseases

Background: Autoimmune diseases can be caused by genes people inherit from their parents. The gene changes that cause these diseases have been well studied in people with European and Asian ancestors...

Bethesda, MD300 participantsNational Human Genome Research Institute (NHGRI)

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NCT02147405Recruiting

PET Imaging and Lymph Node Assessment of IRIS in People With AIDS

Background: \- Sometimes people with HIV, the virus that causes AIDS, can have new or worsening symptoms soon after starting HIV medications. Often these symptoms are caused by immune reconstitution ...

Bethesda, MD300 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT04864886Recruiting

Metabolic Profiling of Immune Responses in Immune-mediated Diseases

Background: The immune system is the part of the body that fights infection. Some people have immune deficiencies that cause skin rashes, make them get sick often with infections, or make it difficul...

Bethesda, MD300 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT03300830Recruiting

Molecular Characterization of Viral-associated Tumors, Tumors Occurring in the Setting of HIV or Other Immune Disorders and Castleman Disease

Background: A person s genome is the collection of all their genes. A gene instructs individual cells to make proteins. Proteins are involved in all of our body s chemical processes. Genome sequencin...

Bethesda, MD280 participantsNational Cancer Institute (NCI)

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NCT07227311Recruiting

A Study to Evaluate the Efficacy and Safety of Belantamab Mafodotin in Combination With Standard of Care in Participants With Relapsed-Refractory Multiple Myeloma (RRMM)

This study is for adults with multiple myeloma (a type of blood cancer) that has come back after being treated earlier or isn't responding to the current treatment. The main goal is to find out if th...

Bethesda, MDPHASE2200 participantsGlaxoSmithKline

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NCT06722235Recruiting

A Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopenia

Primary immune thrombocytopenia (ITP) is a condition where the immune system mistakenly destroys platelets, which are cells that help stop bleeding. This leads to a low number of platelets, making it ...

Bethesda, MDPHASE3171 participantsTakeda

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NCT01419561Recruiting

Natural History Study of the KSHV Inflammatory Cytokine Syndrome (KICS)

Background: \- KSHV inflammatory cytokine syndrome (KICS) is a newly recognized disease caused by Kaposi sarcoma-associated herpesvirus (KSHV). This virus can cause cancer. People with KICS can have ...

Bethesda, MDPHASE2140 participantsNational Cancer Institute (NCI)

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NCT07096778Recruiting

Inobrodib, Pomalidomide and Dexamethasone in Relapsed or Refractory Multiple Myeloma

The purpose of this study is to learn more about the anti-cancer activity of inobrodib, when given in combination with pomalidomide and dexamethasone, in patients with multiple myeloma that has come b...

Bethesda, MDPHASE2100 participantsCellCentric Ltd.

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NCT00055172Recruiting

Genetic Basis of Immunodeficiency

This study will examine the role of hereditary factors in different forms of severe combined immunodeficiency (SCID). Patients with immunodeficiencies may be eligible for this study. Candidates inclu...

Bethesda, MD100 participantsNational Heart, Lung, and Blood Institute (NHLBI)

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NCT06052618Recruiting

Phase II Study of Pacritinib in Kaposi Sarcoma Herpesvirus (KSHV)-Associated Multicentric Castleman Disease and KSHV-Associated Inflammatory Cytokine Syndrome (KICS)

Background: Kaposi sarcoma herpesvirus (KSHV)-associated inflammatory cytokine syndrome (KICS) and KSHV-multicentric Castleman disease (MCD) occur in people living with HIV. These diseases cause seve...

Bethesda, MDPHASE275 participantsNational Cancer Institute (NCI)

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NCT05398809Recruiting

Evaluate the Efficacy and Safety of Ruxolitinib on Hair Regrowth in Patients With Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED)-Associated Alopecia Areata

Background: Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is a problem of the immune system. In people with APECED, the immune system makes a mistake and attacks the body. S...

Bethesda, MDPHASE270 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT06103838Recruiting

18F-Fluciclovine PET/CT in Multiple Myeloma

Background: Multiple myeloma (MM) is an incurable cancer of certain blood cells. MM often returns after treatment, and most people survive only 5 to 8 years after diagnosis. To improve survival, rese...

Bethesda, MDPHASE260 participantsNational Cancer Institute (NCI)

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NCT05027945Recruiting

A Phase II Study of Allogeneic Hematopoietic Stem Cell Transplant for Subjects With VEXAS (Vacuoles, E1 Enzyme, X-linked, Autoinflammatory, Somatic) Syndrome

Background: Allogeneic hematopoietic stem cell transplant involves taking blood stem cells from a donor and giving them to a recipient. The transplants are used to treat certain diseases and cancers....

Bethesda, MDPHASE254 participantsNational Cancer Institute (NCI)

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NCT06819176Recruiting

Lenacapavir Intensification to Disrupt HIV Reservoirs in Virologically Suppressed People With HIV Receiving Antiretroviral Therapy

Background: Antiretroviral viral therapy (ART) allows people with human immunodeficiency (HIV) to live long, healthy lives. But ART is not a cure. HIV can remain in the body, in infected cells called...

Bethesda, MDPHASE150 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT01306019Recruiting

Lentiviral Gene Transfer for Treatment of Children Older Than Two Years of Age With X-Linked Severe Combined Immunodeficiency (XSCID)

This is a Phase I/II non-randomized clinical trial of ex vivo hematopoietic stem cell (HSC) gene transfer treatment for X-linked severe combined immunodeficiency (XSCID, also known as SCID-X1) using a...

Bethesda, MDPHASE140 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT05642455Recruiting

SPEARHEAD-3 Pediatric Study

This is a pediatric basket study to investigate the safety and efficacy of afamitresgene autoleucel in HLA-A\*02 eligible and MAGE-A4 positive subjects aged 2-17 years of age with advanced cancers....

Bethesda, MDPHASE120 participantsAdaptimmune

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NCT06278337Recruiting

X-linked Moesin Associated Immunodeficiency

Moesin deficiency was initially described in 7 male participants aged 4 to 69 years and is characterized by lymphopenia of the 3 lineages and moderate neutropenia. Genetically, 6 out of 7 participants...

Bethesda, MD16 participantsInstitut National de la Santé Et de la Recherche Médicale, France

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NCT06730126Recruiting

Study of the ITK Inhibitor Soquelitinib to Reduce Lymphoproliferation and Improve Cytopenias in Autoimmune Lymphoproliferative Syndrome (ALPS)-FAS Patients

Background: Autoimmune lymphoproliferative syndrome (ALPS) is a rare disorder of the immune system caused by a mutation in the FAS gene. In ALPS, the body stores too many germ-fighting cells called l...

Bethesda, MDPHASE215 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT07202598Recruiting

Randomized Stepped Wedge Study of Emapalumab in APECED Enteritis

Background: Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), also known as Autoimmune polyendocrine syndrome type-1 (APS-1), is a disease that causes the immune system to atta...

Bethesda, MDPHASE210 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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About Multiple Myeloma Clinical Trials in Bethesda

Multiple myeloma is a cancer of plasma cells in the bone marrow that produce abnormal antibodies. It can cause bone damage, kidney problems, and immune deficiency. Treatments have advanced significantly with proteasome inhibitors, immunomodulatory drugs, and CAR-T cell therapy.

There are currently 34 multiple myeloma clinical trials recruiting participants in Bethesda, MD. These studies are seeking a combined 30,755 participants. Research is being sponsored by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute of Allergy and Infectious Diseases (NIAID), National Cancer Institute (NCI) and 8 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Multiple Myeloma Clinical Trials in Bethesda — FAQ

Are there multiple myeloma clinical trials in Bethesda?

Yes, there are 34 multiple myeloma clinical trials currently recruiting in Bethesda, MD. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Bethesda?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Bethesda research site will contact you about next steps.

Are clinical trials in Bethesda free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Bethesda studies also compensate for your time and travel.

What multiple myeloma treatments are being tested?

The 34 active trials in Bethesda are testing new therapies including novel drugs, biologics, and treatment approaches for multiple myeloma.

Data updated July 17, 2026 from ClinicalTrials.gov