Bethesda, MD9 Active Studies

Sickle Cell Disease Clinical Trials in Bethesda, MD

Find 9 actively recruiting sickle cell disease clinical trials in Bethesda, MD. Connect with local research sites and explore new treatment options.

9
Active Trials
6
Sponsors
1,198
Enrolling

Recruiting Sickle Cell Disease Studies in Bethesda

NCT05153967Recruiting

Cooperative Assessment of Late Effects for SCD Curative Therapies

Sickle Cell Disease is one of the most common genetic diseases in the United States, occurring in approximately 1 in 400 births. Approximately 100,000 individuals are diagnosed with SCD in the United ...

Bethesda, MD750 participantsVanderbilt University Medical Center
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NCT06313398Recruiting

Determination of Red Cell Survival in Sickle Cell Disease and Other Hemoglobinopathies Using Biotin Labeling

Background: Sickle cell disease (SCD) is an inherited disorder of the blood. SCD causes red blood cells (RBCs) to die early. This can lead to a shortage of healthy cells. SCD and other blood disorder...

Bethesda, MD100 participantsNational Heart, Lung, and Blood Institute (NHLBI)
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NCT07599176Recruiting

Partial Stem Cell Transplant for Sickle Cell Disease From Matched Donors

This is a non-ablative (partial) stem cell transplant for patients with severe sickle cell disease or beta-thalassemia requiring red cell transfusions. The intensity of the transplant is slightly incr...

Bethesda, MD90 participantsNational Heart, Lung, and Blood Institute (NHLBI)
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NCT05170412Recruiting

Dietary Intake and Dietary Behaviors in Adults With Sickle Cell Disease

Background: Sickle Cell Disease (SCD) causes blood cells form a crescent shape. It is caused by a genetic mutation in the hemoglobin gene. People with SCD are at increased risk for illnesses like str...

Bethesda, MD80 participantsNational Institutes of Health Clinical Center (CC)
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NCT07224360Recruiting

Safety of Anumigilimab (CSL324) in Adults With Sickle Cell Disease (SCD)

This is a phase 2a, global, multicenter, randomized, double-blind, placebo-controlled study investigating the safety of anumigilimab administered subcutaneously (SC) at the maximum tolerated dose (MTD...

Bethesda, MD63 participantsCSL Behring
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NCT06944067Recruiting

Study to Understand the Genetic Risk of Developing an Immune Response After Blood Transfusions Among Individuals With Sickle Cell Disease

The purpose of this research study is to look at genes and determine how they interact with each other to find changes that could explain why some people's immune systems may respond to blood transfus...

Bethesda, MD50 participantsNational Human Genome Research Institute (NHGRI)
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NCT05904093Recruiting

Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects With Stable Sickle Cell Disease

Background: Sickle cell disease (SCD) is a genetic disease that causes the body to produce abnormal ( sickled ) red blood cells. SCD can cause anemia and life-threatening complications in the lungs, ...

Bethesda, MD25 participantsNational Heart, Lung, and Blood Institute (NHLBI)
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NCT07566494Recruiting

Escalating Doses of VAS-101 in Subjects With Stable Sickle Cell Disease

Background: Sickle cell disease (SCD) is an inherited blood disorder. The disease affects the ability of red blood cells to carry oxygen. Research has shown that curcumin, a natural compound found in...

Bethesda, MD25 participantsNational Heart, Lung, and Blood Institute (NHLBI)
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NCT06442761Recruiting

SCD Stem Cell Mobilization and Apheresis Using Motixafortide

This study is being done to see if the study drug, motixafortide, is safe in participants with sickle cell disease (SCD). Investigators also want to see if the drug will help the body increase the num...

Bethesda, MD15 participantsSt. Jude Children's Research Hospital
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About Sickle Cell Disease Clinical Trials in Bethesda

Sickle cell disease is a group of inherited blood disorders where abnormal hemoglobin causes red blood cells to become rigid and sickle-shaped. It causes pain crises, organ damage, and shortened life expectancy. Treatment includes hydroxyurea, blood transfusions, and gene therapy.

There are currently 9 sickle cell disease clinical trials recruiting participants in Bethesda, MD. These studies are seeking a combined 1,198 participants. Research is being sponsored by Vanderbilt University Medical Center, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health Clinical Center (CC) and 3 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Sickle Cell Disease Clinical Trials in Bethesda — FAQ

Are there sickle cell disease clinical trials in Bethesda?

Yes, there are 9 sickle cell disease clinical trials currently recruiting in Bethesda, MD. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Bethesda?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Bethesda research site will contact you about next steps.

Are clinical trials in Bethesda free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Bethesda studies also compensate for your time and travel.

What sickle cell disease treatments are being tested?

The 9 active trials in Bethesda are testing new therapies including novel drugs, biologics, and treatment approaches for sickle cell disease.

Data updated July 13, 2026 from ClinicalTrials.gov