8 Colorectal Cancer Clinical Trials in Birmingham, AL (2026)

Q: How do I join a clinical trial in Birmingham?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Birmingham research site will contact you.

Recruiting Colorectal Cancer Studies in Birmingham

NCT05174169Recruiting

Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease

This Phase II/III trial will evaluate the what kind of chemotherapy to recommend to patients based on the presence or absences of circulating tumor DNA (ctDNA) after surgery for colon cancer....

Birmingham, ALPHASE21,912 participantsNRG Oncology

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NCT04929223Recruiting

A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)

This open-label, exploratory study is designed to evaluate the safety and efficacy of targeted therapies or immunotherapy as single agents or combinations, in participants with metastatic colorectal c...

Birmingham, ALPHASE1542 participantsHoffmann-La Roche

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NCT05863195Recruiting

Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial

This phase III trial compares hepatic arterial infusion (HAI) (pump chemotherapy) in addition to standard of care chemotherapy versus standard of care chemotherapy alone in treating patients with colo...

Birmingham, ALPHASE3408 participantsECOG-ACRIN Cancer Research Group

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NCT05379595Recruiting

A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer

The purpose of this study is to assess the anti-tumor activity of amivantamab as a monotherapy (Cohorts A, B, and C), to assess the recommended phase 2 combination dose (RP2CD) of amivantamab when add...

Birmingham, ALPHASE1225 participantsJanssen Research & Development, LLC

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NCT04722341Recruiting

Time-Restricted Eating and Cancer: Clinical Outcomes, Mechanisms, and Moderators

The purpose of this study is to test whether the timing of meals can improve treatment adverse events, influence tumor biology and alter a person's mood and behaviors....

Birmingham, ALNA175 participantsCedars-Sinai Medical Center

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NCT05848739Recruiting

A Phase 1-2 of ST316 With Selected Advanced Unresectable and Metastatic Solid Tumors

This is an open-label, two-part, phase 1-2 study designed to determine the safety, tolerability, PK, pharmacodynamics (PD), and proof-of-concept efficacy of ST316 administered IV in subjects with sele...

Birmingham, ALPHASE1130 participantsSapience Therapeutics

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NCT06562543Recruiting

A Trial to Evaluate the Safety and Activity of Fruquintinib in Minority Populations With Advanced, Previously Treated Colorectal Cancer

High blood pressure (hypertension) is a known side effect of the treatment with fruquintinib. Current research does not provide a clear answer whether minority groups such as Black/African American an...

Birmingham, ALPHASE478 participantsTakeda

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NCT06867822Recruiting

Trial of ProAgio in Advanced/Metastatic Colorectal Cancer

This is an open-label Phase I/Ib dose-escalation, dose-expansion clinical trial of the safety, pharmacokinetics and clinical activity of ProAgio combined with 5-fluorouracil, irinotecan (FOLFIRI) and ...

Birmingham, ALPHASE127 participantsUniversity of Alabama at Birmingham

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About Colorectal Cancer Clinical Trials in Birmingham

Colorectal cancer starts in the colon or rectum and is the third most common cancer diagnosed in both men and women. Early detection through screening significantly improves outcomes. Treatments include surgery, chemotherapy, radiation, and targeted therapies.

There are currently 8 colorectal cancer clinical trials recruiting participants in Birmingham, AL. These studies are seeking a combined 3,497 participants. Research is being sponsored by NRG Oncology, Hoffmann-La Roche, ECOG-ACRIN Cancer Research Group and 5 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Colorectal Cancer Clinical Trials in Birmingham — FAQ

Are there colorectal cancer clinical trials in Birmingham?

Yes, there are 8 colorectal cancer clinical trials currently recruiting in Birmingham, AL. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Birmingham?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Birmingham research site will contact you about next steps.

Are clinical trials in Birmingham free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Birmingham studies also compensate for your time and travel.

What colorectal cancer treatments are being tested?

The 8 active trials in Birmingham are testing new therapies including novel drugs, biologics, and treatment approaches for colorectal cancer.

Data updated July 17, 2026 from ClinicalTrials.gov