Birmingham, AL5 Active Studies

Melanoma Clinical Trials in Birmingham, AL

Find 5 actively recruiting melanoma clinical trials in Birmingham, AL. Connect with local research sites and explore new treatment options.

5
Active Trials
4
Sponsors
1,902
Enrolling

Recruiting Melanoma Studies in Birmingham

RecruitingBirmingham, ALNCT05727904

Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.

This is a Phase 3, multicenter, open-label, randomized, parallel group, treatment study to assess the efficacy and safety of lifileucel in combination with pembrolizumab compared with pembrolizumab al...

670 participants
Iovance Biotherapeutics, Inc.
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RecruitingBirmingham, ALNCT02339571

A Phase II/III Trial of Nivolumab, Ipilimumab, and GM-CSF in Patients With Advanced Melanoma

This phase II/III trial studies the side effects of nivolumab and ipilimumab when given together with or without sargramostim and to see how well they work in treating patients with stage III-IV melan...

600 participants
National Cancer Institute (NCI)
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RecruitingBirmingham, ALNCT06568172

Testing the Addition of an Immunotherapy Drug, Cemiplimab (REGN2810), Plus Surgery to the Usual Surgery Alone for Treating Advanced Skin Cancer

This phase III trial compares the effect of adding cemiplimab to standard therapy (surgery with or without radiation) versus standard therapy alone in treating patients with stage III/IV squamous cell...

420 participants
National Cancer Institute (NCI)
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RecruitingBirmingham, ALNCT04511013

A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases

This phase II trial compares the effect of encorafenib, binimetinib, and nivolumab versus ipilimumab and nivolumab in treating patients with BRAF- V600 mutant melanoma that has spread to the brain (br...

112 participants
SWOG Cancer Research Network
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RecruitingBirmingham, ALNCT06007690

A Phase 3 Randomized, Masked, Controlled Trial to Evaluate Efficacy and Safety of Belzupacap Sarotalocan (AU-011) Treatment Compared to Sham Control in Subjects With Primary Indeterminate Lesions or Small Choroidal Melanoma

The primary objective is to determine the safety and efficacy of belzupacap sarotalocan (bel-sar) compared to sham control in patients with primary indeterminate lesions (IL) or small choroidal melano...

100 participants
Aura Biosciences
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About Melanoma Clinical Trials in Birmingham

Melanoma is the most serious type of skin cancer, developing from the pigment-producing cells known as melanocytes. While less common than other skin cancers, melanoma is more likely to spread. Immunotherapy and targeted therapy have revolutionized melanoma treatment.

There are currently 5 melanoma clinical trials recruiting participants in Birmingham, AL. These studies are seeking a combined 1,902 participants. Research is being sponsored by Iovance Biotherapeutics, Inc., National Cancer Institute (NCI), SWOG Cancer Research Network and 1 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Melanoma Clinical Trials in Birmingham — FAQ

Are there melanoma clinical trials in Birmingham?

Yes, there are 5 melanoma clinical trials currently recruiting in Birmingham, AL. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Birmingham?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Birmingham research site will contact you about next steps.

Are clinical trials in Birmingham free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Birmingham studies also compensate for your time and travel.

What melanoma treatments are being tested?

The 5 active trials in Birmingham are testing new therapies including novel drugs, biologics, and treatment approaches for melanoma.

Data updated March 2, 2026 from ClinicalTrials.gov