14 ALS Clinical Trials in Boston, MA (2026)

Q: How do I join a clinical trial in Boston?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you.

Recruiting ALS Studies in Boston

NCT05137665Recruiting

Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures

The goal of the study is to generate a biorepository of longitudinal biofluids-blood (plasma and serum), cerebral spinal fluid (CSF) and urine linked to genetics and longitudinal clinical information ...

Boston, MA1,000 participantsTarget ALS Foundation, Inc.

View Study Details

NCT07454733Recruiting

Do Video Recordings of Multidisciplinary Clinics Improve Quality of Life for People With ALS and Their Caregivers?

Amyotrophic lateral sclerosis (ALS) is a fatal, rare neurodegenerative disease affecting 30,000 people in the United States. The gold standard of care for people with ALS is multidisciplinary clinics ...

Boston, MANA800 participantsTrustees of Dartmouth College

View Study Details

NCT05104710Recruiting

Intermuscular Coherence as a Biomarker for ALS

The specific aims of this study are to: 1. Determine if a painless and quick measurement of muscle activity using surface electrodes can help with the diagnosis of ALS. Specifically, we ask if a meas...

Boston, MA650 participantsUniversity of Chicago

View Study Details

NCT07322003Recruiting

Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS

The goal of this clinical trial is to learn if the drug pridopidine works to treat amyotrophic lateral sclerosis in adults. It will also help to learn about the safety of pridopidine. The main questio...

Boston, MAPHASE3500 participantsPrilenia

View Study Details

NCT07173803Recruiting

The Progressive Supranuclear Palsy Clinical Trial Platform

The Progressive Supranuclear Palsy Clinical Trial Platform (PTP) is a multi-center, multi-regimen clinical trial evaluating the safety and efficacy of investigational products for the treatment of PSP...

Boston, MAPHASE2440 participantsAdam Boxer

View Study Details

NCT07023835Recruiting

Usnoflast Neuromuscular Investigation for Treatment Efficacy in Amyotrophic Lateral Sclerosis

Usnoflast Neuromuscular Investigation for Treatment Efficacy in Amyotrophic Lateral Sclerosis...

Boston, MAPHASE2240 participantsZydus Therapeutics Inc.

View Study Details

NCT07259980Recruiting

A Study to Learn More About the Long-Term Safety of Tofersen (Qalsody) in Participants With Superoxide Dismutase 1 (SOD-1) Amyotrophic Lateral Sclerosis (ALS)

In this study, researchers will learn more about the safety of tofersen, also known as Qalsody®. This is a drug available for doctors to prescribe for participant with a certain type of amyotrophic la...

Boston, MA125 participantsBiogen

View Study Details

NCT06491732Recruiting

EIM Via the Myolex mScan as an ALS Biomarker

Amyotrophic lateral sclerosis (ALS) has been traditionally considered incurable and untreatable. But starting in the 1990s with the introduction of Riluzole, therapies are being discovered and ultimat...

Boston, MA80 participantsBeth Israel Deaconess Medical Center

View Study Details

NCT06665165Recruiting

AMX0114 in Adult Participants With Amyotrophic Lateral Sclerosis

This study is a placebo-controlled Phase I study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of the antisense oligonucleotide (ASO) AMX0114 in adult participants with ...

Boston, MAPHASE148 participantsAmylyx Pharmaceuticals Inc.

View Study Details

NCT04220190Recruiting

RAPA-501 Therapy for ALS

RAPA-501-ALS is a phase 2/3 expansion cohort study of RAPA-501 autologous hybrid TREG/Th2 cells in patients living with amyotrophic lateral sclerosis (pwALS)....

Boston, MAPHASE241 participantsRapa Therapeutics LLC

View Study Details

NCT07287397Recruiting

Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS

PIONEER-ALS is a Phase 1/2, multicenter, open-label, ascending dose, uncontrolled, first-in-human study that will evaluate the safety, tolerability and effects on clinical and biomarker endpoints of i...

Boston, MAPHASE136 participantsVector Y Therapeutics

View Study Details

NCT07294144Recruiting

Tofersen in Non-SOD1 ALS

The goal of this clinical trial is to evaluate whether tofersen is safe and effective in adults with non-SOD1 ALS. Tofersen is currently approved by the U.S. Food and Drug Administration to treat SOD1...

Boston, MAPHASE230 participantsWashington University School of Medicine

View Study Details

NCT06649955Recruiting

Controlling Amyotrophic Lateral Sclerosis Motor Neuron Excitability Study

Following completion of the ALS Early Feasibility Study of the MyoRegulator® device for treatment of ALS (NCT06165172), the CALM study will further assess the feasibility of the MyoRegulator® device t...

Boston, MANA15 participantsPathMaker Neurosystems Inc.

View Study Details

NCT07357428Recruiting

Connect-One: Early Feasibility Study of Connexus® Brain-Computer Interface (BCI)

The Connect-One Study is an early feasibility study to obtain preliminary device safety information for the Connexus Brain-Computer Interface (BCI). The Connexus BCI is intended to be used as: (1) an ...

Boston, MANA2 participantsParadromics

View Study Details

About ALS Clinical Trials in Boston

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor neurons controlling voluntary muscle movement. Also known as Lou Gehrig's disease, it leads to increasing paralysis. Research is actively pursuing disease-modifying treatments and gene therapies.

There are currently 14 als clinical trials recruiting participants in Boston, MA. These studies are seeking a combined 4,007 participants. Research is being sponsored by Target ALS Foundation, Inc., Trustees of Dartmouth College, University of Chicago and 11 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

ALS Clinical Trials in Boston — FAQ

Are there als clinical trials in Boston?

Yes, there are 14 als clinical trials currently recruiting in Boston, MA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Boston?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you about next steps.

Are clinical trials in Boston free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Boston studies also compensate for your time and travel.

What als treatments are being tested?

The 14 active trials in Boston are testing new therapies including novel drugs, biologics, and treatment approaches for als.

Data updated October 27, 2026 from ClinicalTrials.gov