9 Head and Neck Cancer Clinical Trials in Boston, MA (2026)

Q: How do I join a clinical trial in Boston?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you.

Recruiting Head and Neck Cancer Studies in Boston

NCT06385080Recruiting

A Study of Amivantamab Alone or in Addition to Other Treatment Agents in Participants With Recurrent/Metastatic Head and Neck Cancer

The purpose of this study is to determine safety and preliminary efficacy of amivantamab monotherapy, amivantamab in addition to pembrolizumab, amivantamab in addition to paclitaxel and amivantamab in...

Boston, MAPHASE1287 participantsJanssen Research & Development, LLC

View Study Details

NCT07227168Recruiting

A Study of STRO-004 in Adults With Refractory/Recurrent Metastatic Cancer

This is a study to evaluate the safety and preliminary anti-tumor activity of STRO-004 in adults with metastatic cancer. This study includes 3 parts: * Part 1A is a dose escalation study of STRO-004 ...

Boston, MAPHASE1200 participantsSutro Biopharma, Inc.

View Study Details

NCT07182149Recruiting

A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid Tumors

This study is being done to find out of NRM-823 is safe and can treat participants with locally advanced or metastatic solid tumors....

Boston, MAPHASE1150 participantsNormunity AccelCo, Inc.

View Study Details

NCT04900623Recruiting

Risk-adapted Therapy in HPV+ Oropharyngeal Cancer Using Circulating Tumor (ct)HPV DNA Profile - The ReACT Study

This research is being conducted to understand if treatment can be tailored for participants with HPV-related oropharynx cancers using both clinical features (stage of the tumor, smoking status) combi...

Boston, MAPHASE2145 participantsJonathan Schoenfeld, MD, MPH

View Study Details

NCT03875716Recruiting

Study of De_Intensified Postoperative Radiation Therapy for HPV Associated Oropharyngeal Squamous Cell Carcinoma

This research study is studying lowering the standard dose of radiation and chemotherapy after surgery, to minimize the side effects and improve the quality of life....

Boston, MANA111 participantsDana-Farber Cancer Institute

View Study Details

NCT06457503Recruiting

A Study of Toripalimab in Combination With Cisplatin and Gemcitabine in Participants With Recurrent Metastatic Nasopharyngeal Cancer

This study aims to investigate toripalimab with chemotherapy in participants with nasopharyngeal cancer....

Boston, MAPHASE4100 participantsCoherus Oncology, Inc.

View Study Details

NCT07465276Recruiting

Neoadjuvant Ficerafusp Alfa With Pembrolizumab in Resectable SCC

This trial is to evaluate the safety and efficacy of ficerafusp alfa in combination with pembrolizumab prior to surgical resection in participants with resectable, high-risk, locoregionally advanced, ...

Boston, MAPHASE232 participantsDana-Farber Cancer Institute

View Study Details

NCT05726370Recruiting

Preoperative Pembrolizumab and Chemotherapy in Resectable, Recurrent HNSCC

This research study is evaluating effectiveness and safety of a combination of immunotherapy drug, pembrolizumab, with chemotherapy, as a possible treatment before and after surgery for squamous cell ...

Boston, MAPHASE228 participantsDana-Farber Cancer Institute

View Study Details

NCT06239220Recruiting

PD-L1 t-haNK, N-803 IL-15sa and Cetuximab for Recurrent, Metastatic HNSCC

The purpose of this research study is to test the safety and efficacy of the combination of PD-L1 t-haNK (modified immune cells), N-803 (a manufactured protein that stimulates the immune system), and ...

Boston, MAPHASE225 participantsGlenn J. Hanna

View Study Details

About Head and Neck Cancer Clinical Trials in Boston

Head and neck cancers develop in the mouth, throat, larynx, sinuses, or salivary glands. HPV-related oropharyngeal cancers have been increasing in prevalence. Treatment includes surgery, radiation, chemotherapy, and immunotherapy.

There are currently 9 head and neck cancer clinical trials recruiting participants in Boston, MA. These studies are seeking a combined 1,078 participants. Research is being sponsored by Janssen Research & Development, LLC, Sutro Biopharma, Inc., Normunity AccelCo, Inc. and 4 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Head and Neck Cancer Clinical Trials in Boston — FAQ

Are there head and neck cancer clinical trials in Boston?

Yes, there are 9 head and neck cancer clinical trials currently recruiting in Boston, MA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Boston?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you about next steps.

Are clinical trials in Boston free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Boston studies also compensate for your time and travel.

What head and neck cancer treatments are being tested?

The 9 active trials in Boston are testing new therapies including novel drugs, biologics, and treatment approaches for head and neck cancer.

Data updated October 12, 2026 from ClinicalTrials.gov