11 Major Depressive Disorder Clinical Trials in Boston, MA (2026)

Q: How do I join a clinical trial in Boston?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you.

Recruiting Major Depressive Disorder Studies in Boston

NCT05800925Recruiting

Triage Survey for Psychiatry Research Eligibility

TRIAGE-Psych is a survey study designed to assess potential participants' eligibility to screen for industry-sponsored psychiatry clinical trials....

Boston, MA20,000 participantsAdams Clinical

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NCT06786624Recruiting

Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

The study will evaluate the efficacy of NBI-1065845 compared with placebo as an adjunctive treatment in participants with MDD on improving symptoms of depression....

Boston, MAPHASE3200 participantsNeurocrine Biosciences

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NCT06976697Recruiting

Home-Based tDCS Treatment Of Major Depressive Disorder

The REACH-tDCS study will evaluate the safety and efficacy of a noninvasive, at-home self-administered Sooma tDCS brain stimulation treatment for Major Depressive Disorder. The study uses randomized, ...

Boston, MANA200 participantsSooma Medical Inc

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NCT05570812Recruiting

Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV

This study will determine the effects of pregnenolone on brain function, inflammation and depressive symptoms in people with HIV who have depression. Participants in this study will receive a pill of ...

Boston, MAPHASE2120 participantsMassachusetts General Hospital

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NCT05573074Recruiting

Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression - R33

The purpose of this research study is to determine if application of near infrared energy to the forehead can change blood flow in the brains of people with depression. Near infrared energy is like li...

Boston, MANA120 participantsNYU Langone Health

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NCT05450432Recruiting

Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression

The study will consist of a 24-week-long trial examining outcomes in patients with Major Depressive Disorder and suicidal ideation who will receive intravenous (IV) ketamine and intranasal (IN) esketa...

Boston, MAPHASE4100 participantsMassachusetts General Hospital

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NCT06878859Recruiting

Preliminary Efficacy Trial of a Digital Intervention for Depression and Cannabis Use

The purpose of this study is to examine the feasibility, acceptability, and preliminary efficacy of a digital intervention for co-occurring cannabis use and depression. Participants will be randomized...

Boston, MANA80 participantsMassachusetts General Hospital

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NCT05523817Recruiting

Targeting Specific Brain Networks to Treat Specific Symptoms in Depression

Repetitive transcranial magnetic stimulation (rTMS) is a way of non-invasively stimulating specific brain networks and is an established treatment for Major Depressive Disorder (MDD). This proposal wi...

Boston, MANA80 participantsMassachusetts General Hospital

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NCT07230990Recruiting

Mechanisms Of Orbitofrontal Stimulation in Depression

The orbitofrontal cortex (OFC), a region involved in emotional regulation, decision making, and reward processing, is a key area linked to antidepressant response. This study tests whether noninvasive...

Boston, MANA80 participantsSubha Subramanian

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NCT07610928Recruiting

Stress Management and Meditative Movements for Asian Americans With Depression and Physical Symptoms

Many Asian Americans with depression also struggle with physical symptoms-such as pain, fatigue, or other forms of bodily discomfort-that occur at the same time. Right now, there is no proven treatmen...

Boston, MANA70 participantsMassachusetts General Hospital

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NCT07563868Recruiting

Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression

This study is being conducted at Massachusetts General Hospital (MGH) to explore whether adding psychedelic coaching can enhance the effects of ketamine or esketamine maintenance treatment in individu...

Boston, MANA20 participantsMassachusetts General Hospital

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About Major Depressive Disorder Clinical Trials in Boston

Major depressive disorder (MDD) is a severe form of depression characterized by persistent sadness, loss of interest, and impaired daily functioning. Treatment-resistant depression (TRD) affects patients who do not respond to standard therapies. Novel treatments like ketamine, psilocybin, and neuromodulation are being studied.

There are currently 11 major depressive disorder clinical trials recruiting participants in Boston, MA. These studies are seeking a combined 21,070 participants. Research is being sponsored by Adams Clinical, Neurocrine Biosciences, Sooma Medical Inc and 3 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Major Depressive Disorder Clinical Trials in Boston — FAQ

Are there major depressive disorder clinical trials in Boston?

Yes, there are 11 major depressive disorder clinical trials currently recruiting in Boston, MA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Boston?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you about next steps.

Are clinical trials in Boston free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Boston studies also compensate for your time and travel.

What major depressive disorder treatments are being tested?

The 11 active trials in Boston are testing new therapies including novel drugs, biologics, and treatment approaches for major depressive disorder.

Data updated October 18, 2026 from ClinicalTrials.gov