91 Osteogenesis Imperfecta Clinical Trials in Boston, MA (2026)

Q: Are there osteogenesis imperfecta clinical trials in Boston?

Yes, there are 91 osteogenesis imperfecta clinical trials currently recruiting in Boston, MA.

Q: How do I join a clinical trial in Boston?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you.

Q: Are clinical trials in Boston free?

Yes, clinical trial participation is always free. Study-related treatments, medical tests, and doctor visits are provided at no cost.

Recruiting Osteogenesis Imperfecta Studies in Boston

NCT06350409Recruiting

Adolescent Outcomes of Post-operative Opioid EXposure

The goal of this observational study is to examine the factors associated with the transition from medical exposure to opioids with "signposts" of future opioid use disorder among adolescent surgical ...

Boston, MA20,000 participantsSharon Levy

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NCT05550298Recruiting

Multi-Center Molecular Diagnosis and Host Response of Respiratory Viral Infections in Pediatric Transplant Recipients

The participants are being asked to take part in this clinical trial, a type of research study, because the participants are scheduled to receive or have recently received a hematopoietic cell transpl...

Boston, MA2,000 participantsArkansas Children's Hospital Research Institute

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NCT04098445Recruiting

TRANSPIRE: Lung Injury in a Longitudinal Cohort of Pediatric HSCT Patients

Hematopoietic stem cell transplant (HSCT) is an effective but toxic therapy and pulmonary morbidity affects as many as 25% of children receiving transplant. Early pulmonary injury includes diffuse alv...

Boston, MA2,000 participantsChildren's Hospital Medical Center, Cincinnati

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NCT07358078Recruiting

DemonsTTRate: A Global, Observational, Multicenter, Long-term Study of Patients With ATTR-CM in a Real-World Setting

The purpose of this study is to: * Describe the clinical characteristics of adult patients with transthyretin-mediated amyloidosis with cardiomyopathy (ATTR-CM) treated with vutrisiran in routine cli...

Boston, MA2,000 participantsAlnylam Pharmaceuticals

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NCT06465810Recruiting

Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis

The MaesTTRo study aims to enroll a global cohort of patients with transthyretin (ATTR) amyloidosis to longitudinally observe the natural course of the disease and describe real-world treatment patter...

Boston, MA1,850 participantsAstraZeneca

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NCT04561518Recruiting

ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated Amyloidosis (ATTR Amyloidosis)

The purpose of this study is to: * Describe epidemiological and clinical characteristics, natural history and real-world clinical management of ATTR amyloidosis patients * Characterize the safety and...

Boston, MA1,500 participantsAlnylam Pharmaceuticals

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NCT02523118Recruiting

OMEGA: Outcome Measures in Eosinophilic Gastrointestinal Disorders Across the Ages

The purpose of this observational study is to find the best measures to define how well a person with eosinophilic disorder is doing. People with EoE, EoG, EoN and EoC normally undergo endoscopy and/o...

Boston, MA1,350 participantsChildren's Hospital Medical Center, Cincinnati

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NCT04375033Recruiting

A Study Comparing Oral Buprenorphine and Injectable Buprenorphine for the Treatment of Opioid Use Disorder

VA-BRAVE will determine whether a 28-day long-acting injectable sub-cutaneous (in the belly area) formulation of buprenorphine at a target dose of 300mg is superior in retaining Veterans in opioid tre...

Boston, MAPHASE4952 participantsVA Office of Research and Development

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NCT06323824Recruiting

Office-based Methadone Versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatment.

The purpose of this clinical trial is to compare the effectiveness of office-based methadone with pharmacy administration and/or dispensing to office-based buprenorphine for the treatment of opioid us...

Boston, MAPHASE4600 participantsYale University

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NCT06936878Recruiting

BOLSTER: Learning New Skills to Thrive

This research study is evaluating a new program called Building Out Lifelines for Safety, Trust, Empowerment, and Renewal or (BOLSTER), which was designed to support participants with a gynecological ...

Boston, MANA600 participantsDana-Farber Cancer Institute

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NCT05577819Recruiting

Prevalence and Prediction of ATTR in Ambulatory Patients With HFpEF

Recent studies have shown that transthyretin amyloidosis (ATTR) can sometimes cause a type of heart failure where the pumping function of the heart is normal, also known as Heart Failure with Preserve...

Boston, MANA515 participantsMassachusetts General Hospital

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NCT05865301Recruiting

Outcomes in Pediatric and Young Adult B-Cell Malignancies After Commercially Available Immunotherapy

To use a consistent and standardized platform to retrospectively and prospectively study children and young adults with B cell malignancies receiving Immunotherapy, blinatumomab and/or inotuzumab ozog...

Boston, MA500 participantsStanford University

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NCT07690436Recruiting

Retinal Fundus Imaging and OCT Imaging for Ocular Detection of ATTR-CM

This multicenter pilot study will enroll adult participants with a confirmed clinical diagnosis of transthyretin amyloid cardiomyopathy (ATTR-CM) and heart failure (HF) controls with documentation wit...

Boston, MA500 participantsAstraZeneca

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NCT06328127Recruiting

Positive Psychology Intervention for Hematopoietic Stem Cell Transplantation Survivors

This randomized clinical trial is evaluating the impact of a positive psychology intervention (PATH) on anxiety symptoms, depression symptoms, and quality of life in survivors of hematopoietic stem ce...

Boston, MANA400 participantsBrigham and Women's Hospital

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NCT04256317Recruiting

A Multi-phase Study of ASTX030 (Azacitidine and Cedazuridine) in Myeloid Neoplasm Alone or in Combination With Venetoclax in AML (AZTOUND Study)

Study ASTX030-01 is a multi-phase study comprising of Phases 1-3 Monotherapy arms and a Phase 1 Combination Therapy arm Phase 1 Monotherapy consists of an open-label Dose Escalation Stage (Stage A) us...

Boston, MAPHASE2316 participantsTaiho Oncology, Inc.

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NCT07427043Recruiting

Robotic Opioid-free Prostatectomy Enhanced Strategy (ROPES)

This prospective, interventional, open-label, phase 3 randomized study evaluates a multimodal analgesia discharge pathway to reduce automatic opioid prescribing following routine robotic-assisted lapa...

Boston, MAPHASE3300 participantsBrigham and Women's Hospital

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NCT05769218Recruiting

PrEP and MOUD Rapid Access for Persons Who Inject Drugs: The CHORUS+ Study

The US opioid overdose epidemic has been accompanied by an increase in human immunodeficiency (HIV) among persons who inject drugs. HIV pre-exposure prophylaxis (PrEP) is an FDA approved medication ta...

Boston, MANA284 participantsBoston Medical Center

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NCT06188585Recruiting

Randomized Trial of UI-EWD vs. Conventional Endoscopic Therapy for Nonvariceal Upper Gastrointestinal Bleeding

A prospective, multi-center, noninferiority randomized controlled trial designed to compare the efficacy of UI-EWD (Nexpowder™) hemostatic powder versus conventional endoscopic hemostatic therapy in p...

Boston, MANA278 participantsMedtronic - MITG

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NCT02747888Recruiting

Hereditary Risk Factors for Thyroid Cancer

Thyroid cancers can occur sporadically, but can also be found as tumors that cluster in families with other cancers or genetic syndromes. Researchers are studying thyroid cancer in children and famili...

Boston, MANA250 participantsDana-Farber Cancer Institute

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NCT05811364Recruiting

The GORE VBX FORWARD Clinical Study: A Comparison of the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis to Bare Metal Stenting for Patients With Complex Iliac Occlusive Disease

The objective of this prospective, multicenter, randomized, controlled clinical trial is to demonstrate the superiority of the VBX Device for primary patency when compared to bare metal stenting in co...

Boston, MANA244 participantsW.L.Gore & Associates

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NCT07214311Recruiting

Evaluation of PLG0206 in Prevention of Recurrent Infection in Patients Undergoing Debridement, Antibiotics, and Implant Retention (DAIR) for Treatment of a Periprosthetic Joint Infection (PJI) Following Knee Arthroplasty

The goal of this clinical trial is to evaluate whether the investigational drug PLG0206 can help reduce recurrence of infection in adults who have undergone total knee replacement and are receiving a ...

Boston, MAPHASE2240 participantsPeptilogics

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NCT06292780Recruiting

A Trial to Learn if Linvoseltamab is Safe and Works in Adults With Relapsed or Refractory Systemic Light Chain Amyloidosis (AL Amyloidosis)

This study is researching an experimental drug called linvoseltamab ("study drug"). This study is focused on patients who have AL amyloidosis that has returned or have failed other therapies and need...

Boston, MAPHASE1220 participantsRegeneron Pharmaceuticals

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NCT05375643Recruiting

SURGE: Supporting UnderRepresented Minorities in Genomics-based Cancer Trial Enrollment (Intervention)

SURGE aims to increase equity in clinical trial enrollment by addressing barriers to genomic testing, which is increasingly needed to assess precision clinical trial eligibility and access standard pr...

Boston, MANA210 participantsNadine McCleary, MD, MPH

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NCT05361941Recruiting

Multicenter Trial of Antibiotic Eluting Graft for Promoting New Bone Growth In/near Infected Bone Cavities

This is a pivotal, prospective, multi-center, randomized, concurrent control, patient and assessor-blinded study with two arms: a treatment arm (where subjects will be treated with the EP Granules wit...

Boston, MANA204 participantsElute, Inc.

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NCT06472128Recruiting

Novel Digital Application for Patients With Acute Leukemia

This research study is evaluating to examine the efficacy of a novel a self-administered digital application (DREAMLAND) for improving patients' long-term quality of life and psychological outcomes fo...

Boston, MANA200 participantsMassachusetts General Hospital

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NCT07112287Recruiting

Germline Testing for Predisposition to Myeloid Malignancies

The goal of this research study is to evaluate the feasibility of germline genetic testing using the investigational MyeloGen Gene Panel in adult participants diagnosed with myeloid malignancies....

Boston, MANA200 participantsChristopher Reilly

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NCT02641145Recruiting

Molecular Imaging of Primary Amyloid Cardiomyopathy

Cardiac amyloidosis is a major cause of early treatment-related death and poor overall survival in individuals with systemic light chain amyloidosis. This project will develop a novel approach to visu...

Boston, MANA171 participantsBrigham and Women's Hospital

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NCT03593759Recruiting

Cardiac Sarcoidosis Randomized Trial

Prospective randomized controlled trial comparing low dose Prednisone(or Prednisolone)/Methotrexate combination to standard dose Prednisone(or Prednisolone) in patients diagnosed with acute active cli...

Boston, MAPHASE3160 participantsOttawa Heart Institute Research Corporation

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NCT04798469Recruiting

Pain Alleviation With Testosterone in Opioid-Induced Hypogonadism

The aim of this trial is to evaluate whether testosterone replacement results in greater improvement in pain perception, pain tolerance, sexual function, fatigue, and quality of life when compared wit...

Boston, MAPHASE2150 participantsBrigham and Women's Hospital

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NCT07223203Recruiting

TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy

The purpose of this study is to: * Determine the efficacy of nucresiran in patients with hATTR-PN by evaluating the effect on neurologic impairment, quality of life, nutritional status, disability, a...

Boston, MAPHASE3125 participantsAlnylam Pharmaceuticals

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NCT07115745Recruiting

A Study of Healthy Donor CD19-targeted Allogeneic CAR T Cells in Participants With Severe, Refractory Autoimmune Diseases

The purpose of this study is to determine the safety, tolerability, optimal dose, and preliminary efficacy of BMS-986515, a healthy donor (HD) allogeneic CD19-targeted CART cell product, in participan...

Boston, MAPHASE1125 participantsJuno Therapeutics, Inc., a Bristol-Myers Squibb Company

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NCT06118086Recruiting

Study of REM-422 in Patients With Recurrent, Metastatic, or Unresectable Adenoid Cystic Carcinoma

The goal of this study is to determine the safety and antitumor effects of REM-422, a MYB mRNA degrader, in people with advanced Adenoid Cystic Carcinoma (ACC)...

Boston, MAPHASE1125 participantsRemix Therapeutics

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NCT07315997Recruiting

The Coronary Artery Calcium and Troponins in Rheumatoid Arthritis (CAT-RA) Study

Individuals with rheumatoid arthritis (RA) have up to 2x the risk of having a heart attack compared to someone without RA. The goal of this study is to identify biomarkers that can help us do a better...

Boston, MA120 participantsBrigham and Women's Hospital

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NCT06630234Recruiting

A Master Protocol to Evaluate DCC-3009 in Gastrointestinal Stromal Tumor (GIST)

The purpose of this Phase 1/2 master protocol study is to evaluate if DCC-3009 is safe, tolerable and works effectively in the treatment of GIST. The study will use a modular approach with each module...

Boston, MAPHASE1120 participantsDeciphera Pharmaceuticals, LLC

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NCT07003100Recruiting

A Prospective, US-based Study Assessing Mogamulizumab-associated Rash in Patients Diagnosed With Mycosis Fungoides or Sezary Syndrome and Treated With Standard of Care Mogamulizumab

This study is being done to assess mogamulizumab-associated rash in patients diagnosed with mycosis fungoides or sezary syndrome and treated with standard of care mogamulizumab. One of the most common...

Boston, MA100 participantsCity of Hope Medical Center

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NCT05970562Recruiting

Project 4: Ambulatory Biofeedback and Voice Therapy for Patients With Vocal Hyperfunction

Vocal hyperfunction (VH) is the most commonly treated class of voice disorders by speech-language pathologists and voice therapy is the primary curative treatment. Patients and clinicians report that ...

Boston, MAEARLY_PHASE1100 participantsMassachusetts General Hospital

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NCT06732596Recruiting

Sustaining Recovery for People on Opioid Agonist Treatment With Conversational Agents

This study aims to improve retention in buprenorphine treatment, a medication used for opioid use disorder, through the use of a smartphone-delivered recovery support intervention. The intervention in...

Boston, MANA100 participantsBoston Medical Center

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NCT06738030Recruiting

Transcranial Stimulation Combined With Auditory Training

The goal of this clinical trial is to learn if non-invasive brain stimulation (called transcranial stimulation) can enhance the benefits from auditory training in people who struggle to understand one...

Boston, MANA94 participantsBoston University Charles River Campus

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NCT07081646Recruiting

A Phase 1b/2 Study of CAR T Cell Therapy Targeting CD19 and BCMA in Participants With Relapsed or Refractory AL Amyloidosis.

Open-label Phase 1b/2 study with primary objective of this study is to evaluate the safety, tolerability and efficacy of AZD0120 in participants with light chain (AL) amyloidosis....

Boston, MAPHASE191 participantsAlexion Pharmaceuticals, Inc.

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NCT06564233Recruiting

Supportive Care Intervention for Outpatient Stem Cell Transplant Patients

The overall goal of this study is to assess the efficacy of the care.coach Avatar™ in improving anxiety and quality of life for patients undergoing outpatient transplant. After care.coach Avatar™ cont...

Boston, MANA90 participantsVictor Wang

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NCT06841705Recruiting

Early Vedolizumab as First-Line for Immune-Related Colitis Therapy Trial

The goal of this clinical trial is to compare the effectiveness and safety of Vedolizumab with a short course of steroids compared to standard course of steroids for the treatment of immune checkpoint...

Boston, MAPHASE280 participantsShilpa Grover, MD, MPH

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NCT06158854Recruiting

A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Immunoglobulin Light Chain (AL) Amyloidosis Receiving Etentamig (ABBV-383) as an Intravenous (IV) Infusion

Immunoglobulin light chain (AL) amyloidosis is the most common form of systemic amyloidosis. AL amyloidosis has many root causes and is characterized by the overproduction of AL that are secreted by c...

Boston, MAPHASE176 participantsAbbVie

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NCT06707493Recruiting

Ivosidenib as Post-HSCT Maintenance for AML

This is a Phase 2 study of the study drug, ivosidenib (a mutant IDH1 inhibitor), compared to placebo, given to patients with IDH1-mutant acute myeloid leukemia (AML) after hematopoietic stem cell tran...

Boston, MAPHASE275 participantsMassachusetts General Hospital

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NCT03113643Recruiting

SL-401 in Combination With Azacitidine or Azacitidine/Venetoclax in Acute Myeloid Leukemia (AML), High-Risk Myelodysplastic Syndrome (MDS) or Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)

This research study is studying a drug as a possible treatment for diagnosis of AML, BPDCN and high-risk MDS. The interventions involved in this study are: * SL-401 * Azacitidine * Venetoclax...

Boston, MAPHASE172 participantsDana-Farber Cancer Institute

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NCT05955261Recruiting

A Study of Venetoclax in Combination With Conventional Chemotherapy in Pediatric Patients With Acute Myeloid Leukemia

This is a phase 2 study to test the hypothesis that venetoclax in combination with standard chemotherapy will be tolerable and active in pediatric patients with newly diagnosed acute myeloid leukemia ...

Boston, MAPHASE270 participantsSt. Jude Children's Research Hospital

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NCT04667494Recruiting

Ultrasound Therapy In Cardiac Amyloidosis

This is a prospective pilot clinical study of subjects with cardiac amyloidosis and control subjects without amyloidosis where we plan to evaluate changes in myocardial blood flow, systolic and diasto...

Boston, MAPHASE470 participantsBrigham and Women's Hospital

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NCT07270276Recruiting

The Impact of Dry Needling on Electrophysiological and Ultrasound-based Biomarkers for Myofascial Pain

The goal of this interventional study is to determine how well dry-needling can treat pain in people with Myofascial Pain Syndrome. The main questions it aims to answer are: * Does dry needling impro...

Boston, MANA70 participantsBeth Israel Deaconess Medical Center

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NCT05143996Recruiting

CLN-049 in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)

CLN-049-001 is a Phase 1, open-label, multicenter, first-in-human trial of CLN-049 in patients with Relapsed/Refractory Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)...

Boston, MAPHASE160 participantsCullinan Therapeutics Inc.

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NCT06898177Recruiting

Development and Testing of a Mobile App to Scale Delivery of Cognitive-behavioral Therapy for Avoidant/Restrictive Food Intake Disorder

Avoidant/restrictive food intake disorder (ARFID) is a serious and impairing eating disorder - occurring in up to 4% of adults - for which most individuals do not have access to treatment. The propose...

Boston, MANA60 participantsMassachusetts General Hospital

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NCT06484062Recruiting

Testing the Anti-cancer Drug, Cirtuvivint, and Its Combination With ASTX727 to Improve Outcomes in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndromes

This phase I trial tests the safety, side effects, and best dose of SM08502 (cirtuvivint) alone and in combination with ASTX727 in treating patients with acute myeloid leukemia (AML) and myelodysplast...

Boston, MAPHASE154 participantsNational Cancer Institute (NCI)

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NCT06660368Recruiting

BCL2i CLAG-M in R/R Acute Myeloid Leukemia

This multicenter, open-label phase II study combines CLAG-based therapy with or without venetoclax in patients with relapsed or refractory (R/R) acute myeloid leukemia (AML) in order to improve measur...

Boston, MAPHASE252 participantsH. Lee Moffitt Cancer Center and Research Institute

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NCT05587127Recruiting

Exposure-Based CBT for Avoidant/Restrictive Food Intake in Functional Dyspepsia

Randomized controlled trial of an exposure-based behavioral treatment (CBT) in adults with functional dyspepsia who meet criteria for avoidant/restrictive food intake disorder (ARFID) with weight loss...

Boston, MANA50 participantsMassachusetts General Hospital

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NCT01788410Recruiting

MRI-Guided Cryoablation to Alleviate Pain in Head, Neck and Spine

The objective of this study is to provide pain relief to patients with facet joint disease or head and neck pain related to compression of a nerve root. The goal is to provide palliative care with sup...

Boston, MA50 participantsBrigham and Women's Hospital

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NCT04024761Recruiting

A Phase 1 Trial of CIML NK Cell Infusion for Myeloid Disease Relapse After Hematopoietic Cell Transplantation

This research study is studying cytokine induced memory-like natural killer (CIML NK) cells combined with IL-2 in adult patients (18 years of age or older) with Acute Myeloid Leukemia (AML), Myelodysp...

Boston, MAPHASE150 participantsDana-Farber Cancer Institute

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NCT06051890Recruiting

Assessing Optimal XRB Initiation Points in Jail

This application describes a 3-year, randomized controlled trial. Eligible, consenting adults (N=200) with existing sublingual buprenorphine (SLB) prescriptions who enter Middlesex County House of Cor...

Boston, MAPHASE450 participantsNYU Langone Health

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NCT07567131Recruiting

Observational Study of Adults and Adolescents With Erythropoietic Protoporphyria (EPP) and X-linked Porphyria (XLP)

The purpose of this study is to collect information about the effects of EPP/XLP in adults and adolescents. This is an observational study in which participants will not receive any treatment. Study d...

Boston, MA50 participantsPortal Therapeutics, Inc.

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NCT06569147Recruiting

Elranatamab in Patients With Relapsed or Refractory AL Amyloidosis

This study will evaluate the safety, tolerability and efficacy of elranatamab in patients with relapsed or refractory AL amyloidosis....

Boston, MAPHASE149 participantsBrigham and Women's Hospital

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NCT06201416Recruiting

Study of Single Doses of SBT777101 in Subjects With Rheumatoid Arthritis

This study will test the safety and effects of SBT777101 when given as a single dose to subjects with rheumatoid arthritis. It is the first study of this treatment being done in humans. Increasing dos...

Boston, MAPHASE148 participantsSonoma Biotherapeutics, Inc.

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NCT07439211Recruiting

Assessing PI3K Gamma Inhibition With Azacitidine, Venetoclax and Eganelisib in Patients With Acute Myeloid Leukemia

This study is to evaluate the safety and preliminary efficacy of adding the PI3K-gamma inhibitor, eganelisib, to a standard of care treatment option with combination venetoclax and azacitidine in part...

Boston, MAPHASE148 participantsJacqueline Garcia, MD

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NCT07406633Recruiting

KQB198 in Combination With Imatinib in Participants With Advanced/Metastatic GIST in 1st Line Setting (SynerGIST-1st Line)

This study will test an experimental drug called KQB198 in combination with imatinib. The goal is to determine if this combination is safe and tolerable and assess how effective the combination is at ...

Boston, MAPHASE246 participantsKumquat Biosciences Inc.

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NCT06639464Recruiting

Semaglutide for Helping Opioid Recovery

The is a pilot, 12-week, double-blind, placebo-controlled, randomized trial of individuals with opioid use disorder (OUD) newly initiating buprenorphine to receive either weekly injections of semaglut...

Boston, MAPHASE246 participantsBrigham and Women's Hospital

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NCT07020533Recruiting

A Vaccine (CMV-MVA Triplex Vaccine) for the Enhancement of CMV-Specific Immunity and the Prevention of CMV Viremia in Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplant

This phase Ib trial tests the safety, side effects, and how well cytomegalovirus (CMV)-modified vaccinia Ankara (MVA) Triplex vaccine works in enhancing CMV-specific immunity and preventing CMV viremi...

Boston, MAPHASE146 participantsCity of Hope Medical Center

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NCT07104331Recruiting

SARC046: A Phase II Trial of Nab-Sirolimus in Patients With Progressing or Symptomatic Epithelioid Hemangioendothelioma

This is a non-randomized, open label, single arm Phase II trial with a two-stage design with histologically-confirmed metastatic and/or recurrent epithelioid hemangioendothelioma requiring systemic tr...

Boston, MAPHASE241 participantsSarcoma Alliance for Research through Collaboration

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NCT06676852Recruiting

Feasibility and Acceptability of Primary Palliative Care Intervention in Patients Undergoing Hematopoietic Stem Cell Transplantation

Primary PC - or training HCT clinicians to deliver PC domains as part of routine practice - is an alternative model of supportive care. We have developed Sentinel, a primary PC intervention for HCT cl...

Boston, MANA40 participantsMassachusetts General Hospital

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NCT05797857Recruiting

Exercise Training in Transthyretin Cardiac Amyloidosis

Transthyretin cardiac amyloidosis causes debilitating heart failure in older adults. The proposed research will develop a personalized exercise training program to improve functional capacity in patie...

Boston, MANA40 participantsBrigham and Women's Hospital

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NCT07614906Recruiting

Nitric Oxide Consumption as a Predictor of Vasospasm in Subarachnoid Hemorrhage

The goal of this observational study is to understand if angiographic cerebral vasospasm (CV) can be predicted by levels of nitric oxide (NO) consumption in patients with aneurysmal subarachnoid hemor...

Boston, MA40 participantsMassachusetts General Hospital

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NCT07123038Recruiting

A Long-Term Follow-Up Observational Study to Evaluate Safety in Subjects Who Have Received a Gene-Modified Regulatory T Cell (Treg) Therapeutic

To assess the emergence, type, severity, and potential causality of delayed adverse events following administration of a gene-modified Treg therapeutic....

Boston, MA36 participantsSonoma Biotherapeutics, Inc.

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NCT06247787Recruiting

A Study to Find the Highest Dose of Imetelstat in Combination With Fludarabine and Cytarabine for Patients With AML, MDS or JMML That Has Come Back or Does Not Respond to Therapy

This phase I trial tests the safety, side effects, and best dose of imetelstat in combination with fludarabine and cytarabine in treating patients with acute myeloid leukemia (AML), myelodysplastic sy...

Boston, MAPHASE136 participantsChildren's Oncology Group

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NCT06494423Recruiting

Employment Support After Hematopoietic Stem Cell Transplantation

This is a feasibility study of a Work Support (WorkS) intervention designed to ameliorate employment challenges for people preparing to return to work after allogeneic stem cell transplantation. The a...

Boston, MANA35 participantsMGH Institute of Health Professions

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NCT04925479Recruiting

Study to Determine the Dose and Safety of Asciminib in Pediatric Patients With Chronic Myeloid Leukemia

The aim of this study is to support development of asciminib in the pediatric population (1 to \<18 years) previously treated with one or more TKIs. Full extrapolation of the efficacy of asciminib fro...

Boston, MAPHASE134 participantsNovartis Pharmaceuticals

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NCT04883671Recruiting

Stereotactic Body Radiotherapy (SBRT) for Early Treatment of Oligometastatic Adenoid Cystic Carcinoma: The SOLAR Trial

The aim of this study is to learn whether the early initiation of a specialized and focused type of radiation called stereotactic body radiation therapy (SBRT) will impact the progression of advanced ...

Boston, MANA32 participantsDana-Farber Cancer Institute

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NCT05774899Recruiting

CB-103 With Either Lenvatinib or Abemaciclib in Patients With NOTCH ACC

The goal of this study is to treat patients with NOTCH active advanced adenoid cystic carcinoma (ACC) tumors with a combination or two different oral medications to slow tumor growth and improve survi...

Boston, MAPHASE132 participantsGlenn J. Hanna

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NCT05024929Recruiting

Targeted Therapy to Increase RAI Uptake in Metastatic DTC

Papillary thyroid cancer (PTC) is a common type of differentiated thyroid cancer (DTC) in children and represents the second most common cancer in adolescent females. Recently targeted drugs that bloc...

Boston, MA32 participantsChildren's Hospital of Philadelphia

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NCT07148180Recruiting

A Multi-Site Break Through Cancer Trial: Targeting Measurable Residual Disease in Patients With Acute Myeloid Leukemia: A Phase 1/2 Study of Tagraxofusp, Azacitidine, and Venetoclax

The purpose of this research study is to test the safety and efficacy of a new drug combination with three agents, azacitidine, venetoclax and tagraxofusp. Leftover (residual) leukemia disease that is...

Boston, MAPHASE131 participantsJacqueline Garcia, MD

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NCT05668962Recruiting

Restor. I-131 Upt. + Selpercatinib in RET F-P RAI-R TC

This research is being done to determine the efficacy of selpercatinib to restore radioactive iodine (I-131 NaI) uptake and allow for I-131 treatment in people with RET fusion-positive radioiodine-ref...

Boston, MAPHASE230 participantsMassachusetts General Hospital

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NCT07374029Recruiting

Adoptive T Cell Therapy With DC/AML Fusion Vaccine Plus Decitabine and Venetoclax in AML

The goal of this research study is to test if the combination of a new T cell therapy (dendritic cell (DC) / acute myeloid leukemia (AML) primed T cells), vaccine (DC/AML fusion vaccine) and standard ...

Boston, MAPHASE130 participantsDavid Avigan

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NCT05103566Recruiting

Safety, Feasibility, and Efficacy of Non-invasive Vagus Nerve Stimulation (nVNS) in the Treatment of Aneurysmal Subarachnoid Hemorrhage

This is a single-site, single-arm, open-label pilot study assessing the safety, feasibility, and efficacy of non-invasive vagus nerve stimulation (nVNS), gammaCore, for the acute treatment of aneurysm...

Boston, MANA25 participantsMassachusetts General Hospital

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NCT07110844Recruiting

Teclistamab-Daratumumab in AL Amyloidosis

The purpose of this study is to investigate whether teclistamab-daratumumab combination is effective and safe in AL amyloidosis. The study treatment is divided into cycles (C) and each cycle is 28 da...

Boston, MAPHASE225 participantsSuzanne Lentzsch, MD

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NCT07404982Recruiting

Reversal of Spinal Anesthesia Residual Motor Block Via Intrathecal Catheter

The purpose of this study is to determine the feasibility of administering a predetermined amount of normal saline into the intrathecal or subarachnoid space via a small spinal catheter to reduce or e...

Boston, MAPHASE224 participantsBeth Israel Deaconess Medical Center

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NCT05703542Recruiting

BXCL701 Phase 1 R/R Acute Myeloid Leukemia or Myelodysplastic Syndrome

The goal of this research study is to find the safest and most effective dose of the study drug, BXCL701, for the treatment of Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS). The name...

Boston, MAPHASE124 participantsEric Stephen Winer, MD

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NCT06643884Recruiting

Suprachoroidal Administration in Subjects With Choroidal Metastasis From Breast or Lung Primary Tumors

The primary objective is to assess the safety and tolerability of bel-sar treatment in subjects with choroidal metastasis from breast or lung primary tumors....

Boston, MAPHASE224 participantsAura Biosciences

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NCT06440135Recruiting

Ziftomenib Maintenance Post Allo-HCT

The purpose of this study is to test the safety, effects, and recommended dose of an investigational drug, ziftomenib, in addition to the standard treatment on blood cancer with Allogeneic Hematopoiet...

Boston, MAPHASE122 participantsMassachusetts General Hospital

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NCT06313437Recruiting

Revumenib in Combination With 7+3 + Midostaurin in AML

This research is being conducted to determine a safe and effective dose of revumenib that can be given in combination with standard induction (initial therapy to induce a remission) + FLT3 targeted th...

Boston, MAPHASE122 participantsRichard Stone, MD

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NCT05335434Recruiting

Intraoral Photobiomodulation Therapy to Prevent Oral Mucositis in Patients Undergoing Hematopoietic Cell Transplantation

This is a single center pilot study evaluating intraoral photobiomodulation for the prevention of oral mucositis in patients undergoing myeloablative allogeneic hematopoietic cell transplantation (all...

Boston, MANA20 participantsDana-Farber Cancer Institute

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NCT07560306Recruiting

[64Cu]FBP8 PET for Early Detection of Intracardiac Thrombus in Amyloid Cardiomyopathy

The primary goal of this pilot study is to determine whether \[64Cu\]FBP8, a novel fibrin-binding positron emission tomography (PET) probe, can identify intracardiac thrombi when paired with simultane...

Boston, MAPHASE320 participantsBrigham and Women's Hospital

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NCT06001749Recruiting

Psilocybin in Cancer Pain Study

The overall objective of this study is to assess the feasibility, safety and preliminary efficacy of psilocybin-assisted therapy to alleviate opioid-refractory pain in patients with advanced-cancer. ...

Boston, MAPHASE215 participantsYvan Beaussant, MD, MSci

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NCT06138587Recruiting

Preemptive CIML NK Cell Therapy After Hematopoietic Stem Cell Transplantation

The purpose of this research study is to test the safety and efficacy of cytokine induced memory-like (CIML) natural killer (NK) cells expanded with Interleukin-2 (IL-2) at preventing relapse in acute...

Boston, MAPHASE115 participantsDana-Farber Cancer Institute

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NCT06902376Recruiting

XL092 and Cemiplimab in BRAF WT Thyroid Cancer

This multicenter study examines the safety and feasibility of the combination of neoadjuvant XL092 and cemiplimab prior to surgical resection in participants with wild-type (WT) anaplastic thyroid can...

Boston, MAPHASE112 participantsUNC Lineberger Comprehensive Cancer Center

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NCT06152809Recruiting

CIML NK Cells With Venetoclax for AML

The purpose of this research study is to test the safety and to explore the effectiveness of infusing cytokine- induced memory-like (CIML) natural killer (NK) cells in combination with Interleukin-2 (...

Boston, MAPHASE110 participantsDana-Farber Cancer Institute

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NCT06284486Recruiting

A Multi-Site Break Through Cancer Trial: Phase II Study Investigating Dual Inhibition of BCL2 and Menin in AML MRD Using the Combination of Venetoclax and Revumenib

To learn if the combination of venetoclax and revumenib can help to control MRD-positive AML....

Boston, MAPHASE18 participantsM.D. Anderson Cancer Center

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NCT04225611Recruiting

Therapeutic Contact Lens Drug Delivery System (TCL-DDS) in Patients With Recurrent Cystoid Macular Edema

The main aim of the pilot study is to determine preliminary estimates of the safety, tolerability, and comfort of a dexamethasone-eluting therapeutic contact lens drug delivery system (TCL-DDS) for th...

Boston, MAPHASE16 participantsMassachusetts Eye and Ear Infirmary

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About Osteogenesis Imperfecta Clinical Trials in Boston

Osteogenesis imperfecta is a group of genetic disorders mainly affecting the bones, causing them to break easily, often from little or no apparent cause. It is caused by defects in collagen production. Treatment includes bisphosphonates, physical therapy, and surgical rodding.

There are currently 91 osteogenesis imperfecta clinical trials recruiting participants in Boston, MA. These studies are seeking a combined 41,417 participants. Research is being sponsored by Sharon Levy, Arkansas Children's Hospital Research Institute, Children's Hospital Medical Center, Cincinnati and 52 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Osteogenesis Imperfecta Clinical Trials in Boston — FAQ

Are there osteogenesis imperfecta clinical trials in Boston?

Yes, there are 91 osteogenesis imperfecta clinical trials currently recruiting in Boston, MA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Boston?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you about next steps.

Are clinical trials in Boston free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Boston studies also compensate for your time and travel.

What osteogenesis imperfecta treatments are being tested?

The 91 active trials in Boston are testing new therapies including novel drugs, biologics, and treatment approaches for osteogenesis imperfecta.

Data updated October 12, 2026 from ClinicalTrials.gov