13 Substance Use Disorder Clinical Trials in Boston, MA (2026)

Q: How do I join a clinical trial in Boston?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you.

Recruiting Substance Use Disorder Studies in Boston

NCT07232641Recruiting

Impact of Federal and State Medications for Opioid Use Disorder (MOUD) Policy Changes During the Pandemic

"Gold-standard" medications for opioid use disorder (MOUD) treatment combines FDA-approved medications, primarily methadone and buprenorphine, with behavioral therapies to provide "whole-patient" trea...

Boston, MA185,810 participantsBoston University

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NCT06350409Recruiting

Adolescent Outcomes of Post-operative Opioid EXposure

The goal of this observational study is to examine the factors associated with the transition from medical exposure to opioids with "signposts" of future opioid use disorder among adolescent surgical ...

Boston, MA20,000 participantsSharon Levy

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NCT04375033Recruiting

A Study Comparing Oral Buprenorphine and Injectable Buprenorphine for the Treatment of Opioid Use Disorder

VA-BRAVE will determine whether a 28-day long-acting injectable sub-cutaneous (in the belly area) formulation of buprenorphine at a target dose of 300mg is superior in retaining Veterans in opioid tre...

Boston, MAPHASE4952 participantsVA Office of Research and Development

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NCT06323824Recruiting

Office-based Methadone Versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatment.

The purpose of this clinical trial is to compare the effectiveness of office-based methadone with pharmacy administration and/or dispensing to office-based buprenorphine for the treatment of opioid us...

Boston, MAPHASE4600 participantsYale University

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NCT06395467Recruiting

Integrated Treatment for Enhancing Growth in Recovery During Adolescence

This is a Phase II parallel group randomized controlled trial with 294 adolescents (age: 14-21 years) with alcohol and other drug \[AOD\] use disorder (hereafter substance use disorder), that compares...

Boston, MANA294 participantsMassachusetts General Hospital

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NCT05769218Recruiting

PrEP and MOUD Rapid Access for Persons Who Inject Drugs: The CHORUS+ Study

The US opioid overdose epidemic has been accompanied by an increase in human immunodeficiency (HIV) among persons who inject drugs. HIV pre-exposure prophylaxis (PrEP) is an FDA approved medication ta...

Boston, MANA284 participantsBoston Medical Center

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NCT05929677Recruiting

Impulsivity Domains and Subjective Response

Findings from this project will determine the relationship between two vulnerability factors for Alcohol Use Disorder (AUD) in young adults: impulsivity and subjective response to alcohol. The results...

Boston, MAEARLY_PHASE1250 participantsJessica Weafer

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NCT06051890Recruiting

Assessing Optimal XRB Initiation Points in Jail

This application describes a 3-year, randomized controlled trial. Eligible, consenting adults (N=200) with existing sublingual buprenorphine (SLB) prescriptions who enter Middlesex County House of Cor...

Boston, MAPHASE4200 participantsNYU Langone Health

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NCT07010978Recruiting

Towards Testing the Effectiveness of Recovery Community Centers (RCCs)

The goal of this pilot randomized clinical trial is to prepare for a larger randomized clinical trial (RCT) and collect some early data to learn if the intervention can help people who use medications...

Boston, MANA128 participantsMassachusetts General Hospital

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NCT06732596Recruiting

Sustaining Recovery for People on Opioid Agonist Treatment With Conversational Agents

This study aims to improve retention in buprenorphine treatment, a medication used for opioid use disorder, through the use of a smartphone-delivered recovery support intervention. The intervention in...

Boston, MANA100 participantsBoston Medical Center

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NCT06639464Recruiting

Semaglutide for Helping Opioid Recovery

The is a pilot, 12-week, double-blind, placebo-controlled, randomized trial of individuals with opioid use disorder (OUD) newly initiating buprenorphine to receive either weekly injections of semaglut...

Boston, MAPHASE246 participantsBrigham and Women's Hospital

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NCT06727331Recruiting

Study of Tirzepatide for Recovery and Alcohol Use Management

This is a pilot, 4-week, double-blind, placebo-controlled, randomized trial of individuals with alcohol use disorder (AUD) to receive weekly injections of either tirzepatide (n=10) or matching placebo...

Boston, MAPHASE220 participantsBrigham and Women's Hospital

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NCT05817825Recruiting

Pilot Testing a Novel Remotely Delivered Intensive Outpatient Program for Individuals With OUD

This study aims to test a remotely delivered IOP program ("SmartIOP") for OUD patients who are hospitalized for serious injection-related infections. This will be a pilot trial to assess the feasibili...

Boston, MANA20 participantsBrigham and Women's Hospital

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About Substance Use Disorder Clinical Trials in Boston

Substance use disorder is a condition where the use of substances leads to health issues, disability, and failure to meet responsibilities. It encompasses alcohol, opioid, stimulant, and other drug addictions. Treatment includes behavioral therapy, medication-assisted treatment, and support programs.

There are currently 13 substance use disorder clinical trials recruiting participants in Boston, MA. These studies are seeking a combined 208,704 participants. Research is being sponsored by Boston University, Sharon Levy, VA Office of Research and Development and 6 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Substance Use Disorder Clinical Trials in Boston — FAQ

Are there substance use disorder clinical trials in Boston?

Yes, there are 13 substance use disorder clinical trials currently recruiting in Boston, MA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Boston?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you about next steps.

Are clinical trials in Boston free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Boston studies also compensate for your time and travel.

What substance use disorder treatments are being tested?

The 13 active trials in Boston are testing new therapies including novel drugs, biologics, and treatment approaches for substance use disorder.

Data updated July 19, 2026 from ClinicalTrials.gov