26 Colorectal Cancer Clinical Trials in Boston, NY (2026)

Q: How do I join a clinical trial in Boston?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you.

Recruiting Colorectal Cancer Studies in Boston

NCT04792684Recruiting

Collection of Samples USOPTIVAL Study

A prospective multi-center observational study. The study will enroll eligible subjects from the United States to optimize the biomarker panel and evaluate the performance of a cfDNA marker panel sele...

Boston, NY1,300 participantsUniversal Diagnostics

View Study Details

NCT05410977Recruiting

Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients

This study collects blood and stool samples from patients with suspected or diagnosed Lynch syndrome to evaluate a deoxyribonucleic acid (DNA) screening technique for the detection of colorectal cance...

Boston, NY950 participantsMayo Clinic

View Study Details

NCT03803553Recruiting

Identification and Treatment Of Micrometastatic Disease in Stage III Colon Cancer

This research study is comparing two standard of care treatment options based on blood test results for participants who have metastatic colon cancer. The names of the potential treatments involved i...

Boston, NY400 participantsMassachusetts General Hospital

View Study Details

NCT06820463Recruiting

A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer

CRC is the third most common type of cancer diagnosed worldwide with developed countries at highest risk. The purpose of this study is to assess adverse events and change in disease activity when teli...

Boston, NY390 participantsAbbVie

View Study Details

NCT03659448Recruiting

Performance of SGM-101 for the Delineation of Primary and Recurrent Tumor and Metastases in Patients Undergoing Surgery for Colorectal Cancer

The performance of SGM-101, an intraoperative imaging agent, will be compared to that of standard "white light" visualization during surgical resections of colorectal cancer....

Boston, NY300 participantsSurgimab

View Study Details

NCT07300150Recruiting

A Study of PT0511 in Participants With KRAS Mutated or Amplified Advanced Solid Tumors

The primary purpose of this study is to evaluate the safety and tolerability, determine the maximally tolerated dose (MTD) and/or recommended Phase 2 dose(s) (RP2D) of PT0511 in adult participants wit...

Boston, NY210 participantsPAQ Therapeutics, Inc.

View Study Details

NCT07527858Recruiting

Study of Denikitug (GS-1811) Given Alone or With Nivolumab or With Chemotherapy in Adults With Advanced Colorectal Cancer

The goal of this clinical study is to learn more about the study drug, Denikitug (DEN, GS-1811), to evaluate the efficacy and safety of Denikitug Monotherapy and Denikitug-based Combinations in partic...

Boston, NY170 participantsGilead Sciences

View Study Details

NCT07127874Recruiting

A Study of PHN-012 in Patients With Advanced Solid Tumors

This first-in-human study will evaluate safety, tolerability, anti-tumor activity, immunogenicity, pharmacokinetics and pharmacodynamics of PHN-012, a novel antibody-drug conjugate (ADC), in patients ...

Boston, NY165 participantsPheon Therapeutics

View Study Details

NCT05319314Recruiting

LYL273 for Patients With Relapsed or Refractory mCRC

This is a Phase 1/2 open-label, multicenter study evaluating the safety and efficacy of LYL273 in participants with relapsed or refractory metastatic colorectal cancer....

Boston, NY155 participantsLyell Immunopharma, Inc.

View Study Details

NCT07023289Recruiting

A Study to Assess Adverse Events and Change in Disease Activity in Adult Participants Receiving Intravenously Infused Telisotuzumab Adizutecan Alone or With Standard of Care in Participants With Post Adjuvant Circulating Tumor DNA Positive Colorectal Cancer and No Radiographic Evidence of Disease

Colorectal cancer (CRC) is the third most common type of cancer diagnosed worldwide. The purpose of this study is to assess change in disease activity when telisotuzumab adizutecan is given alone comp...

Boston, NY140 participantsAbbVie

View Study Details

NCT05848739Recruiting

A Phase 1-2 of ST316 With Selected Advanced Unresectable and Metastatic Solid Tumors

This is an open-label, two-part, phase 1-2 study designed to determine the safety, tolerability, PK, pharmacodynamics (PD), and proof-of-concept efficacy of ST316 administered IV in subjects with sele...

Boston, NY130 participantsSapience Therapeutics

View Study Details

NCT06792695Recruiting

A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer

The main purpose of this study is to evaluate the safety and efficacy of novel study interventions and combinations in participants with Colorectal Cancer (CRC)....

Boston, NY120 participantsAstraZeneca

View Study Details

NCT06202183Recruiting

Exercise for Gut Microbiome in Patients With Young-Onset Colorectal Cancer Undergoing Chemotherapy: The COURAGE Trial

This research study is a randomized controlled trial that will observe changes in microbiome activity, changes in chemotherapy toxicity, and any changes in treatment outcomes between two groups of par...

Boston, NY84 participantsDana-Farber Cancer Institute

View Study Details

NCT02172651Recruiting

Vitamin D in Patients With Stage I-III Colon Cancer or Resectable Colon Cancer Liver Metastases

This study seeks to learn more about the vitamin D receptor and its relationship to colon cancer. The Vitamin D receptor is found in colon cancer cells. When Vitamin D binds to the receptor in the can...

Boston, NY80 participantsDana-Farber Cancer Institute

View Study Details

NCT05692024Recruiting

COffee and Metabolites Modulating the Gut MicrobiomE in Colorectal caNCER

This is research study is assessing the effects of 6-g daily use of freeze-dried instant coffee on liver fat and fibrosis and the gut microbiome and metabolome in patients who have completed routine t...

Boston, NY80 participantsMassachusetts General Hospital

View Study Details

NCT05914766Recruiting

An Informational and Supportive Care Intervention for Patients With Locally Advanced Rectal Cancer

The aim of this study is to evaluate the feasibility and acceptability of conducting a randomized trial of a brief psychoeducational intervention versus enhanced usual care for patients with locally a...

Boston, NY80 participantsMassachusetts General Hospital

View Study Details

NCT02584244Recruiting

Feasibility of the LUM Imaging System for Detection of Gastrointestinal Cancers

The overall goal of this feasibility study is to assess the initial safety and efficacy of LUM015 in ex vivo far-red imaging of colorectal, pancreatic, and esophageal cancers (adenocarcinoma) using th...

Boston, NY66 participantsLumicell, Inc.

View Study Details

NCT03516708Recruiting

Epacadostat (INCB024360) Added to Preoperative Chemoradiation in Patients With Locally Advanced Rectal Cancer

The purpose of this research study is to evaluate epacadostat when given with routine radiation therapy and chemotherapy (capecitabine and oxaliplatin) to treat rectal cancer before routine surgery is...

Boston, NY49 participantsWashington University School of Medicine

View Study Details

NCT06763432Recruiting

Positive Fit to Colonoscopy: Closing the Gap

The goals of this proposal are to: (1) identify patient- and system-level determinants of diagnostic colonoscopy after positive FIT; (2) identify patient- and system-level equity-driven implementation...

Boston, NY45 participantsMassachusetts General Hospital

View Study Details

NCT06565052Recruiting

The Impact of PReOPerative Exercise and NutritionaL Optimization on Perioperative Outcomes for Patients Undergoing Treatment for Rectal Cancer: The PROPEL Trial

The purpose of this study is to determine the feasibility of a prehabilitation program for participants diagnosed with rectal cancer undergoing neoadjuvant chemotherapy and/or radiation, followed by s...

Boston, NY40 participantsDana-Farber Cancer Institute

View Study Details

NCT06757192Recruiting

CRC Screening in Unscreened Individuals 45-54

The goal of this observational study is to understand the barriers and facilitators to completing colorectal cancer screening from the patient and community health center staff perspective. The main q...

Boston, NY40 participantsMassachusetts General Hospital

View Study Details

NCT07162337Recruiting

BILe Acid-gut Microbiome Axis MODification Through Diet Education for Colorectal Cancer Prevention

This research study is a prospective, single-arm clinical trial to assess the effect of a dietary intervention for more plant-based and less animal-based food intake on secondary bile acid production,...

Boston, NY40 participantsMassachusetts General Hospital

View Study Details

NCT06412198Recruiting

A Multicenter Phase 1b/2 Study of Adagrasib, Cetuximab, and Cemiplimab for Metastatic Colorectal Cancer Harboring KRAS G12C Mutations

To learn if the drug combination of adagrasib, cetuximab, and cemiplimab can help to control metastatic CRC with KRAS G12C mutations....

Boston, NY31 participantsM.D. Anderson Cancer Center

View Study Details

NCT07095517Recruiting

Pathways, Risk Factors, and mOleculeS to Prevent Early-onset Colorectal Tumors

This research study is an open-label Phase 1 Exploratory/Pilot clinical trial to measure the effects of the incretin mimetic, tirzepatide, on tissue, urine, blood, and microbiome biomarkers associated...

Boston, NY20 participantsMassachusetts General Hospital

View Study Details

NCT07128355Recruiting

Botensilimab, Balstilimab, and SBRT in Colorectal Cancer

This is a single-arm pilot feasibility study evaluating the combination of Botensilimab and Balstilimab with Radiation Therapy (RT) in Non-Microsatellite Instability High (MSI-H) or Proficient Mismatc...

Boston, NY15 participantsMassachusetts General Hospital

View Study Details

NCT05524428Recruiting

Eliminating Barriers to Colorectal Cancer Screening Using Rapid Cycle Testing: A Pilot Study

The investigators will use a mixed methods study i.e. focus groups involving CHC staff as well as quantitative study which involves analyzing data that is available from the EHR and DRVS population ma...

Boston, NY2 participantsMassachusetts General Hospital

View Study Details

About Colorectal Cancer Clinical Trials in Boston

Colorectal cancer starts in the colon or rectum and is the third most common cancer diagnosed in both men and women. Early detection through screening significantly improves outcomes. Treatments include surgery, chemotherapy, radiation, and targeted therapies.

There are currently 26 colorectal cancer clinical trials recruiting participants in Boston, NY. These studies are seeking a combined 5,102 participants. Research is being sponsored by Universal Diagnostics, Mayo Clinic, Massachusetts General Hospital and 12 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Colorectal Cancer Clinical Trials in Boston — FAQ

Are there colorectal cancer clinical trials in Boston?

Yes, there are 26 colorectal cancer clinical trials currently recruiting in Boston, NY. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Boston?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you about next steps.

Are clinical trials in Boston free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Boston studies also compensate for your time and travel.

What colorectal cancer treatments are being tested?

The 26 active trials in Boston are testing new therapies including novel drugs, biologics, and treatment approaches for colorectal cancer.

Data updated July 13, 2026 from ClinicalTrials.gov