16 Cystic Fibrosis Clinical Trials in Boston, NY (2026)

Q: How do I join a clinical trial in Boston?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you.

Recruiting Cystic Fibrosis Studies in Boston

NCT07048574Recruiting

TIDES 2.0: Prevalence and Longitudinal Course of Depression, Anxiety, and Behavior Problems in Children With Cystic Fibrosis Under 12 Years of Age

This is a longitudinal, observational epidemiological study designed to estimate the prevalence of depression, anxiety, and behavior problems in children ages 18 months through 11 years with cystic fi...

Boston, NY600 participantsState University of New York at Buffalo

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NCT04509050Recruiting

Study to Evaluate Biological & Clinical Effects of Significantly Corrected CFTR Function in Infants & Young Children

This is a two-part, multi-center, prospective longitudinal, exploratory study of highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulators and their impact on children wit...

Boston, NY210 participantsSonya Heltshe

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NCT06837181Recruiting

Studying the Presence of CFRD Complications With Thoughtful Recruitment (SPeCTRuM)

This multicenter cross-sectional study will include a diverse population of adolescents and adults with CF. The overall Aim is to describe prevalence of diabetes microvascular complications and macro...

Boston, NY200 participantsJaeb Center for Health Research

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NCT06237335Recruiting

A Phase 2 Study Evaluating Safety and Tolerability of RCT2100 (CFTR mRNA) in Healthy Participants and in Participants With CF

This is the first-in-human study with RCT2100 and is designed to provide safety and tolerability data for future clinical studies....

Boston, NY192 participantsReCode Therapeutics

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NCT06366724Recruiting

LIFT: Life Improvement Trial

The LIFT will be conducted at Brigham and Women's Hospital (BWH) of Harvard Medical School, focusing on the effect of Pyridostigmine (Mestinon) and Low-Dose Naltrexone (LDN) in subjects aged 18-70 mee...

Boston, NY160 participantsBrigham and Women's Hospital

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NCT06449677Recruiting

Bionic Pancreas in CFRD

This multi-center randomized controlled trial (RCT) will compare efficacy and safety endpoints using the insulin-only configuration of the iLet Bionic Pancreas System (BP) versus a control group using...

Boston, NY150 participantsJaeb Center for Health Research

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NCT06296394Recruiting

Health Outcomes of Parents With Cystic Fibrosis-Aim 2

The goal of this observational prospective study is to determine the health impact of parenthood on United States (US) people with CF in the era of CF transmembrane regulator protein (CFTR) modulators...

Boston, NY146 participantsUniversity of Pittsburgh

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NCT07071324Recruiting

CF Wellness Program

This study is a pilot randomized control trial (RCT; N=80) comparing the Cystic Fibrosis Wellness Program (CFWP) to usual care (UC) to evaluate (1) Intervention Adherence (completion of the CFWP Coach...

Boston, NY80 participantsJohns Hopkins University

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NCT06429176Recruiting

Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of SPL84 in Patients with Cystic Fibrosis

The goal of this clinical trial is to learn if drug SPL84 is safe for adult patients with cystic fibrosis (CF). It will also learn if the drug works to treat works to treat CF with a specific mutation...

Boston, NY64 participantsSpliSense Ltd.

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NCT07031323Recruiting

OnTrackCF: Engagement, Feasibility, and Acceptability Study

This is a multi-site, nonrandomized study using mixed methods approach to evaluate the feasibility, acceptability, and user engagement of OnTrackCF for adults with Cystic Fibrosis (AWCF)....

Boston, NY60 participantsBoston Children's Hospital

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NCT06216704Recruiting

Skeletal Health and Bone Marrow Composition in Adolescents With Cystic Fibrosis

The investigators will be evaluating bone marrow composition via magnetic resonance imaging in adolescents diagnosed with cystic fibrosis (CF) compared to healthy, matched controls. The investigators ...

Boston, NY36 participantsMassachusetts General Hospital

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NCT06747858Recruiting

Safety, Tolerability and Efficacy Study of ARCT-032 in People With Cystic Fibrosis

ARCT-032-02 is a Phase 2, open-label, multicenter, multiple-ascending dose study of ARCT-032 in adults with CF who are not eligible for CFTR modulator therapy or are not taking CFTR modulators due to ...

Boston, NY33 participantsArcturus Therapeutics, Inc.

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NCT05248230Recruiting

4D-710 in Adult Patients With Cystic Fibrosis

This is a Phase 1/2 multicenter, open-label, single dose trial of 4D-710 investigational gene therapy in adults with cystic fibrosis....

Boston, NY30 participants4D Molecular Therapeutics

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NCT06810167Recruiting

Assessing Tenapanor as a Treatment of CF-related Constipation.

Tenapanor is the newest FDA-approved drug for IBS with constipation (IBS-C). This study seeks to understand tenapanor as a treatment for cystic fibrosis-related constipation (CFrC) in CF patients. Par...

Boston, NY25 participantsMassachusetts General Hospital

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NCT05723445Recruiting

The Effects of a Low Glycemic Load Diet on Dysglycemia and Body Composition in Adults With Cystic Fibrosis-Related Diabetes

This study will evalute the effect of a low glycemic load (LGL diet on dysglycemia, insulin requirements, DXA-derived body composition, gastrointestinal symptoms and quality of life measures in adults...

Boston, NY15 participantsRhode Island Hospital

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NCT06526923Recruiting

A Phase 1/2 Trial of SP-101 for the Treatment of Cystic Fibrosis (CF)

This is a Phase 1/2 multicenter, open-label, single dose trial of SP-101 investigational gene therapy in adults with CF who are ineligible for or intolerant to CFTR modulator therapy....

Boston, NY15 participantsSpirovant Sciences, Inc.

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About Cystic Fibrosis Clinical Trials in Boston

Cystic fibrosis is a genetic disorder that causes thick, sticky mucus to build up in the lungs, digestive tract, and other organs. It is caused by mutations in the CFTR gene. CFTR modulator therapies have dramatically improved outcomes, along with airway clearance techniques and nutritional support.

There are currently 16 cystic fibrosis clinical trials recruiting participants in Boston, NY. These studies are seeking a combined 2,016 participants. Research is being sponsored by State University of New York at Buffalo, Sonya Heltshe, Jaeb Center for Health Research and 11 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Cystic Fibrosis Clinical Trials in Boston — FAQ

Are there cystic fibrosis clinical trials in Boston?

Yes, there are 16 cystic fibrosis clinical trials currently recruiting in Boston, NY. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Boston?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you about next steps.

Are clinical trials in Boston free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Boston studies also compensate for your time and travel.

What cystic fibrosis treatments are being tested?

The 16 active trials in Boston are testing new therapies including novel drugs, biologics, and treatment approaches for cystic fibrosis.

Data updated July 13, 2026 from ClinicalTrials.gov