25 Heart Disease Clinical Trials in Boston, NY (2026)

Q: How do I join a clinical trial in Boston?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you.

Recruiting Heart Disease Studies in Boston

NCT05169333Recruiting

The Oxford Risk Factors And Non-Invasive Imaging Study

ORFAN is a prospective, multi-centre, multi-ethnic cohort observational study collecting CT scans, biological material and outcomes data, to develop and validate novel biomarkers of cardiometabolic an...

Boston, NY250,000 participantsUniversity of Oxford

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NCT04604418Recruiting

Outcomes and Health Care Resource Utilization in Pediatric Congenital Heart Disease Patients Undergoing Non-Cardiac Procedures

The incidence of moderate to severe congenital heart disease (CHD) in the United States is estimated to be 6 per 1000 live-born full term infants. Recent advances in pediatric cardiology, surgery and ...

Boston, NY10,000 participantsBoston Children's Hospital

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NCT07559903Recruiting

ANDREAS Registry (Assessment of Novel Drug-coated Balloon Revascularization: Effectiveness, Angiographic Outcomes, and Safety)

The primary objective of this protocol is to develop a comprehensive, multicenter international prospective registry to capture long-term clinical outcomes for adult patients undergoing percutaneous c...

Boston, NY5,000 participantsEmory University

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NCT06235112Recruiting

AI Detection of Incidental Coronary Artery Calcium to Enhance Cardiovascular Disease Prevention

AI INFORM is a multicenter randomized trial that will test the hypothesis that providing clinicians information on the presence and amount of coronary artery calcifications (CAC), will result in initi...

Boston, NYNA1,500 participantsBrigham and Women's Hospital

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NCT07232069Recruiting

PRE-EMPT: Prospective RandomizEd Evaluation and Management of Premature aTherosclerosis

Heart disease is the leading cause of death for men, women, and people of most racial and ethnic groups in the United States. This clinical trial will test if screening and early treatment of mild hea...

Boston, NYPHASE31,500 participantsDuke University

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NCT06854458Recruiting

The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States Study

This research aims to investigate whether symptoms of chest pain or shortness of breath among the study population are arising due to a heart problem, particularly any reduction of blood flow to the h...

Boston, NYNA1,000 participantsBrigham and Women's Hospital

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NCT07286578Recruiting

A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Understanding and Management of Coronary Calcium (The Optimal Trial)

The OPTIMAL randomized clinical trial has been designed to compare two imaging strategies and to test the hypothesis that a calcium modification strategy informed by coronary CT angiography (CCTA) wil...

Boston, NYNA700 participantsFundación EPIC

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NCT06399692Recruiting

REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Women

This is a research study in women to compare the outcomes of two procedures that restore blood flow to the arteries of the heart. In one procedure the blockages are ballooned and then stented with a s...

Boston, NYPHASE3600 participantsWeill Medical College of Cornell University

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NCT06399705Recruiting

REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Minorities

This is a research study in minorities to compare the outcomes of two procedures that restore blood flow to the arteries of the heart. In one procedure the blockages are ballooned and then stented wit...

Boston, NYPHASE3600 participantsWeill Medical College of Cornell University

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NCT07087431Recruiting

Impact of Disclosing Coronary Artery Disease Polygenic Risk Score on Cardiovascular Health

The goal of this clinical trial is to evaluate whether disclosure of a polygenic risk score for coronary artery disease (CAD PRS) influences cardiovascular health and risk factor modification over one...

Boston, NYNA500 participantsMassachusetts General Hospital

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NCT06662500Recruiting

FORWARD CAD IDE Study

The FORWARD CAD IDE Study is a Prospective, Multicenter, Single-Arm, Investigational Device Exemption (IDE) Study conducted to assess the safety and effectiveness of the Shockwave Intravascular Lithot...

Boston, NYNA408 participantsShockwave Medical, Inc.

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NCT00985049Recruiting

TRANSCRIBE (Transcriptomic Analysis of Left Ventricular Gene Expression)

Hypothesis: The investigators hypothesize that genetic variants will alter gene expression in response to ischemia during cardiopulmonary bypass. To test this, the investigators will be taking small p...

Boston, NY350 participantsBrigham and Women's Hospital

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NCT05687292Recruiting

Application of a Clinical Decision Support System to Reduce Mechanical Ventilation Duration After Cardiac Surgery in Children

The goal of this study is to evaluate the impact of a clinical decision support system (CDSS) in children receiving mechanical ventilation (MV) after surgery for congenital heart disease (CHD). The ma...

Boston, NY330 participantsBoston Children's Hospital

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NCT06445608Recruiting

PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm

This purpose of this trial is to demonstrate 30 day safety and effectiveness outcomes of the KARDION CORY P4 System in subjects who require hemodynamic support during a high-risk PCI procedure....

Boston, NYNA310 participantsKardion Inc

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NCT06244199Recruiting

Transition to Cardiac Rehabilitation (T2CR) to Address Barriers of Multimorbidity and Frailty

Cardiac rehabilitation (CR) is a secondary prevention program for patients with cardiovascular disease (CVD). It is especially valuable as CVD increasingly occurs in combination with comorbidity, frai...

Boston, NYNA250 participantsVA Office of Research and Development

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NCT06779630Recruiting

Safety and Effectiveness of the Orsiro Mission 48-mm Sirolimus Eluting Coronary Stent System in Subjects With Coronary Artery Lesions

The purpose of the study is to assess the safety and efficacy of the Orsiro® Mission 48- mm Sirolimus-Eluting Coronary Stent System in the treatment of subjects with atherosclerotic lesion(s) \>36 mm ...

Boston, NYNA150 participantsTeleflex

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NCT05491668Recruiting

Physiological Assessment of Severe Coronary Stenosis for Informing Planned PCI

Traditionally, the severity of a blockage (stenosis) in a coronary artery has been determined by visual angiographic assessment of the diameter of the artery at the level of a blockage compared to a n...

Boston, NY107 participantsBeth Israel Deaconess Medical Center

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NCT07753889Recruiting

Relationships Among Pupil Responses to Light, Circadian Rhythms, and Sleep

The investigators are studying relationships among eye pathology, pupil responses to light, sleep, circadian rhythms, and hormones in healthy individuals and those with various medical disorders or il...

Boston, NYNA100 participantsElizabeth B Klerman MD PhD

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NCT04299828Recruiting

Evaluation of Pro-Inflammatory Leukocyte Activity in Patients Undergoing Cardiac Surgery

The goal of this proposal is to prospectively collect data from a series of 200 patients (all ages) undergoing complex cardiac surgical procedures involving cardiopulmonary bypass (CPB) to: 1. Measur...

Boston, NY100 participantsBoston Children's Hospital

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NCT06408961Recruiting

EVOC - EVs in Obesity and Cardiometabolic Disease

The goal of this observational study is to research the impact of molecular signals from the heart, liver and fat tissue on cardiovascular disease risk, and the presentation of Type II Diabetes and di...

Boston, NY100 participantsMassachusetts General Hospital

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NCT05241418Recruiting

Atrial Late Gadolinium Enhancement in Patients with Repaired Congenital Heart Disease

In this research study the investigators want to learn more about how well the investigators can visualize scar tissue in the heart by MRI. In patients with congenital heart disease who need a procedu...

Boston, NY50 participantsBoston Children's Hospital

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NCT07114718Recruiting

Starlight Cardiovascular Lifeline Ductus Arteriosus Stent IDE Study

Starlight Cardiovascular, Inc. is sponsoring a prospective, multi-center, study to evaluate safety and effectiveness of the Lifeline Ductus Arteriosus Stent System. The study device is a stent that is...

Boston, NYNA45 participantsStarlight Cardiovascular Inc

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NCT07466745Recruiting

Autus Valve Continued Access Study (CAS)

Prospective, single-arm, multi-center, continued access study of the Autus Size-Adjustable Valve in pediatric patients aged 18 months to 16 years requiring surgical pulmonary valve replacement. The Au...

Boston, NYNA36 participantsEdwards Lifesciences

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NCT06434207Recruiting

Extracellular Vesicle Micro RNA Profiling in Congenital Heart Disease: Fetal-Maternal Regulation in Neonatal Thrombosis

Newborns with congenital heart disease (CHD) are at increased risk of developing postpartum and postoperative blood clots after cardiac surgery. The molecular mechanisms that are responsible for the c...

Boston, NY10 participantsBoston Children's Hospital

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NCT06387446Recruiting

Allogeneic Valve Transplantation

Valves will be taken from hearts donated by organ donors, and implanted into patients who need a new heart valve....

Boston, NYNA4 participantsBoston Children's Hospital

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About Heart Disease Clinical Trials in Boston

Heart disease is the leading cause of death worldwide, encompassing conditions that affect the heart and blood vessels. Coronary artery disease, the most common type, occurs when arteries supplying the heart become narrowed or blocked. Risk factors include high blood pressure, high cholesterol, diabetes, and smoking.

There are currently 25 heart disease clinical trials recruiting participants in Boston, NY. These studies are seeking a combined 273,750 participants. Research is being sponsored by University of Oxford, Boston Children's Hospital, Emory University and 13 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Heart Disease Clinical Trials in Boston — FAQ

Are there heart disease clinical trials in Boston?

Yes, there are 25 heart disease clinical trials currently recruiting in Boston, NY. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Boston?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you about next steps.

Are clinical trials in Boston free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Boston studies also compensate for your time and travel.

What heart disease treatments are being tested?

The 25 active trials in Boston are testing new therapies including novel drugs, biologics, and treatment approaches for heart disease.

Data updated August 30, 2026 from ClinicalTrials.gov