22 Heart Disease Clinical Trials in Boston, NY (2026)

Q: How do I join a clinical trial in Boston?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you.

Recruiting Heart Disease Studies in Boston

NCT04604418Recruiting

Outcomes and Health Care Resource Utilization in Pediatric Congenital Heart Disease Patients Undergoing Non-Cardiac Procedures

The incidence of moderate to severe congenital heart disease (CHD) in the United States is estimated to be 6 per 1000 live-born full term infants. Recent advances in pediatric cardiology, surgery and ...

Boston, NY10,000 participantsBoston Children's Hospital

View Study Details

NCT07559903Recruiting

ANDREAS Registry (Assessment of Novel Drug-coated Balloon Revascularization: Effectiveness, Angiographic Outcomes, and Safety)

The primary objective of this protocol is to develop a comprehensive, multicenter international prospective registry to capture long-term clinical outcomes for adult patients undergoing percutaneous c...

Boston, NY5,000 participantsEmory University

View Study Details

NCT06235112Recruiting

AI Detection of Incidental Coronary Artery Calcium to Enhance Cardiovascular Disease Prevention

AI INFORM is a multicenter randomized trial that will test the hypothesis that providing clinicians information on the presence and amount of coronary artery calcifications (CAC), will result in initi...

Boston, NY1,500 participantsBrigham and Women's Hospital

View Study Details

NCT06854458Recruiting

The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States Study

This research aims to investigate whether symptoms of chest pain or shortness of breath among the study population are arising due to a heart problem, particularly any reduction of blood flow to the h...

Boston, NY1,000 participantsBrigham and Women's Hospital

View Study Details

NCT06310031Recruiting

Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure

The goal of this study is to evaluate the safety and efficacy of the BrioVAD System by demonstrating non-inferiority to the HeartMate 3 Left Ventricular Assist System when used for the treatment of ad...

Boston, NY780 participantsBrioHealth Solutions, Inc.

View Study Details

NCT07286578Recruiting

A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Understanding and Management of Coronary Calcium (The Optimal Trial)

The OPTIMAL randomized clinical trial has been designed to compare two imaging strategies and to test the hypothesis that a calcium modification strategy informed by coronary CT angiography (CCTA) wil...

Boston, NY700 participantsFundación EPIC

View Study Details

NCT06399705Recruiting

REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Minorities

This is a research study in minorities to compare the outcomes of two procedures that restore blood flow to the arteries of the heart. In one procedure the blockages are ballooned and then stented wit...

Boston, NY600 participantsWeill Medical College of Cornell University

View Study Details

NCT06399692Recruiting

REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Women

This is a research study in women to compare the outcomes of two procedures that restore blood flow to the arteries of the heart. In one procedure the blockages are ballooned and then stented with a s...

Boston, NY600 participantsWeill Medical College of Cornell University

View Study Details

NCT07087431Recruiting

Impact of Disclosing Coronary Artery Disease Polygenic Risk Score on Cardiovascular Health

The goal of this clinical trial is to evaluate whether disclosure of a polygenic risk score for coronary artery disease (CAD PRS) influences cardiovascular health and risk factor modification over one...

Boston, NY500 participantsMassachusetts General Hospital

View Study Details

NCT06662500Recruiting

FORWARD CAD IDE Study

The FORWARD CAD IDE Study is a Prospective, Multicenter, Single-Arm, Investigational Device Exemption (IDE) Study conducted to assess the safety and effectiveness of the Shockwave Intravascular Lithot...

Boston, NY408 participantsShockwave Medical, Inc.

View Study Details

NCT00985049Recruiting

TRANSCRIBE (Transcriptomic Analysis of Left Ventricular Gene Expression)

Hypothesis: The investigators hypothesize that genetic variants will alter gene expression in response to ischemia during cardiopulmonary bypass. To test this, the investigators will be taking small p...

Boston, NY350 participantsBrigham and Women's Hospital

View Study Details

NCT05687292Recruiting

Application of a Clinical Decision Support System to Reduce Mechanical Ventilation Duration After Cardiac Surgery in Children

The goal of this study is to evaluate the impact of a clinical decision support system (CDSS) in children receiving mechanical ventilation (MV) after surgery for congenital heart disease (CHD). The ma...

Boston, NY330 participantsBoston Children's Hospital

View Study Details

NCT06445608Recruiting

PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm

This purpose of this trial is to demonstrate 30 day safety and effectiveness outcomes of the KARDION CORY P4 System in subjects who require hemodynamic support during a high-risk PCI procedure....

Boston, NY310 participantsKardion Inc

View Study Details

NCT06244199Recruiting

Transition to Cardiac Rehabilitation (T2CR) to Address Barriers of Multimorbidity and Frailty

Cardiac rehabilitation (CR) is a secondary prevention program for patients with cardiovascular disease (CVD). It is especially valuable as CVD increasingly occurs in combination with comorbidity, frai...

Boston, NY250 participantsVA Office of Research and Development

View Study Details

NCT06779630Recruiting

Safety and Effectiveness of the Orsiro Mission 48-mm Sirolimus Eluting Coronary Stent System in Subjects With Coronary Artery Lesions

The purpose of the study is to assess the safety and efficacy of the Orsiro® Mission 48- mm Sirolimus-Eluting Coronary Stent System in the treatment of subjects with atherosclerotic lesion(s) \>36 mm ...

Boston, NY150 participantsTeleflex

View Study Details

NCT05491668Recruiting

Physiological Assessment of Severe Coronary Stenosis for Informing Planned PCI

Traditionally, the severity of a blockage (stenosis) in a coronary artery has been determined by visual angiographic assessment of the diameter of the artery at the level of a blockage compared to a n...

Boston, NY107 participantsBeth Israel Deaconess Medical Center

View Study Details

NCT04299828Recruiting

Evaluation of Pro-Inflammatory Leukocyte Activity in Patients Undergoing Cardiac Surgery

The goal of this proposal is to prospectively collect data from a series of 200 patients (all ages) undergoing complex cardiac surgical procedures involving cardiopulmonary bypass (CPB) to: 1. Measur...

Boston, NY100 participantsBoston Children's Hospital

View Study Details

NCT06408961Recruiting

EVOC - EVs in Obesity and Cardiometabolic Disease

The goal of this observational study is to research the impact of molecular signals from the heart, liver and fat tissue on cardiovascular disease risk, and the presentation of Type II Diabetes and di...

Boston, NY100 participantsMassachusetts General Hospital

View Study Details

NCT05241418Recruiting

Atrial Late Gadolinium Enhancement in Patients with Repaired Congenital Heart Disease

In this research study the investigators want to learn more about how well the investigators can visualize scar tissue in the heart by MRI. In patients with congenital heart disease who need a procedu...

Boston, NY50 participantsBoston Children's Hospital

View Study Details

NCT07114718Recruiting

Starlight Cardiovascular Lifeline Ductus Arteriosus Stent IDE Study

Starlight Cardiovascular, Inc. is sponsoring a prospective, multi-center, study to evaluate safety and effectiveness of the Lifeline Ductus Arteriosus Stent System. The study device is a stent that is...

Boston, NY35 participantsStarlight Cardiovascular Inc

View Study Details

NCT06434207Recruiting

Extracellular Vesicle Micro RNA Profiling in Congenital Heart Disease: Fetal-Maternal Regulation in Neonatal Thrombosis

Newborns with congenital heart disease (CHD) are at increased risk of developing postpartum and postoperative blood clots after cardiac surgery. The molecular mechanisms that are responsible for the c...

Boston, NY10 participantsBoston Children's Hospital

View Study Details

NCT06387446Recruiting

Allogeneic Valve Transplantation

Valves will be taken from hearts donated by organ donors, and implanted into patients who need a new heart valve....

Boston, NY4 participantsBoston Children's Hospital

View Study Details

About Heart Disease Clinical Trials in Boston

Heart disease is the leading cause of death worldwide, encompassing conditions that affect the heart and blood vessels. Coronary artery disease, the most common type, occurs when arteries supplying the heart become narrowed or blocked. Risk factors include high blood pressure, high cholesterol, diabetes, and smoking.

There are currently 22 heart disease clinical trials recruiting participants in Boston, NY. These studies are seeking a combined 22,884 participants. Research is being sponsored by Boston Children's Hospital, Emory University, Brigham and Women's Hospital and 10 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Heart Disease Clinical Trials in Boston — FAQ

Are there heart disease clinical trials in Boston?

Yes, there are 22 heart disease clinical trials currently recruiting in Boston, NY. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Boston?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you about next steps.

Are clinical trials in Boston free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Boston studies also compensate for your time and travel.

What heart disease treatments are being tested?

The 22 active trials in Boston are testing new therapies including novel drugs, biologics, and treatment approaches for heart disease.

Data updated July 13, 2026 from ClinicalTrials.gov