28 Atrial Fibrillation Clinical Trials in Boston, NY (2026)

Q: How do I join a clinical trial in Boston?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you.

Recruiting Atrial Fibrillation Studies in Boston

NCT06953726Recruiting

Comparing the Safety and Efficacy of Apixaban and Rivaroxaban

* The trial will compare two anticoagulants ("blood thinners") that are currently used in the VA and are considered standard care to prevent strokes in patients with atrial fibrillation. The two most ...

Boston, NY10,000 participantsVA Office of Research and Development

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NCT06615596Recruiting

Discontinuation of Anticoagulations After Successful Catheter Ablation of Atrial Fibrillation

The DESTINATION Study investigates whether anticoagulation therapy is necessary after successful catheter ablation (CA) for atrial fibrillation (AF). Current guidelines recommend continued anticoagula...

Boston, NY3,160 participantsChina National Center for Cardiovascular Diseases

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NCT06957366Recruiting

Perioperative Anticoagulant Use for Surgery Evaluation -2 (PAUSE-2) Study Patients Receiving a Direct Oral Anticoagulant (DOACs-Dabigatran, Rivaroxaban, Apixaban or Edoxaban) and Needing Elective High-Bleed-Risk Surgery or an Invasive Procedure

PAUSE 2 study is a prospective, open-label, blinded-endpoint non-inferiority RCT of PAUSE vs. ASRA management in DOAC treated high risk patients with AF/VTE who need elective high bleed risk surgery/p...

Boston, NY920 participantsMcMaster University

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NCT06876649Recruiting

A Master Protocol to Evaluate the Long-Term Safety of (LY3527727) Pirtobrutinib

The master protocol study J2N-MC-JZNY provides a framework to enable the evaluation of the long-term safety and efficacy of pirtobrutinib after completion of clinical studies evaluating pirtobrutinib....

Boston, NY787 participantsEli Lilly and Company

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NCT07523750Recruiting

A Study of VARIPULSE Pulsed Field Ablation (PFA) Catheter and FARAWAVE PFA Catheter in the Treatment of Participants With Persistent Atrial Fibrillation

The purpose of this study is to assess how safe VARIPULSE pulsed field ablation (PFA) catheter is and how well it works compared to food and drug administration (FDA) approved FARAWAVE PFA catheter in...

Boston, NY466 participantsBiosense Webster, Inc.

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NCT06099730Recruiting

Safety and Effectiveness of Pulmonary Vein isOLation And posterioR Wall Ablation wIth pulSed Field Energy in Patients With Paroxysmal and Persistent AF

The primary objective of this clinical investigation is to demonstrate the safety and 12-month effectiveness of pulmonary vein isolation (PVI) and posterior LA wall isolation in the treatment of subje...

Boston, NY442 participantsMassachusetts General Hospital

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NCT07298473Recruiting

Conquer-AF Protocol for Redo Ablation Procedures in Recurrent Paroxysmal and Persistent Atrial Fibrillation Using the Sphere-9 Catheter and Affera Ablation System (Conquer-AF)

Conquer-AF is a prospective, multi-center, interventional, non-randomized clinical study that will enroll up to 400 subjects at up to 30 sites across the United States, Europe, and Australia. Subject...

Boston, NY400 participantsMedtronic Cardiac Ablation Solutions

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NCT07308847Recruiting

Horizon 360 Protocol for the Treatment of Paroxysmal Atrial Fibrillation With the Sphere-360™ Catheter and Affera™ Mapping and Ablation System (Horizon 360)

The study is a prospective, single-arm, pre-market clinical study and will enroll up to 300 subjects at up to 26 sites in the United States (US) for analysis of primary objectives. No single site may ...

Boston, NY300 participantsMedtronic Cardiac Ablation Solutions

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NCT05952583Recruiting

Selective Fetal Growth Restriction in Monochorionic Twins - an International Investigation

Optimal diagnostic management and underlying pathophysiological mechanisms of selective fetal growth restriction (sFGR) in monochorionic diamniotic (MCDA) twin pregnancies have not been fully clarifie...

Boston, NY274 participantsLeiden University Medical Center

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NCT07173998Recruiting

Quality of Life in Patients With Postoperative Atrial Fibrillation After Cardiac Surgery

Prospective observational study on quality of life with postoperative atrial fibrillation after cardiac surgery using SF-36 and qualitative questions...

Boston, NY260 participantsBrigham and Women's Hospital

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NCT06324201Recruiting

The Long-term Safety and Effectiveness Evaluation of the QDOT MICRO System Use in Conjunction With VISITAG SURPOINT Module for the Treatment of Symptomatic Drug Refractory Paroxysmal Atrial Fibrillation.

Observational, multi-center, non-randomized, post-market study. This is a nested sub-study of the REAL AF Registry. Consecutive symptomatic drug refractory paroxysmal atrial fibrillation (PAF) patient...

Boston, NY250 participantsHeart Rhythm Clinical and Research Solutions, LLC

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NCT05867173Recruiting

Perceptual Consequences of Cochlear Implant Electrode-neuron Interfaces

Despite the success of cochlear implants, devices surgically placed in the inner ears of patients with severe hearing loss, there remains substantial variability in the overall speech perception outco...

Boston, NY200 participantsMassachusetts Eye and Ear Infirmary

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NCT03830320Recruiting

Positron Emission Tomography (PET) Imaging of Thrombosis

The purpose of the study is to evaluate a new radiotracer called 64Cu-FBP8 for PET-MR imaging of thrombosis. The tracer has the potential of detecting thrombosis anywhere in the body, for instance in ...

Boston, NY165 participantsMassachusetts General Hospital

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NCT03546374Recruiting

Medtronic Terminate AF Study

The purpose of this study is to demonstrate the safety and effectiveness of the Cardioblate iRF and CryoFlex hand held devices for the treatment of non-paroxysmal atrial fibrillation (AF)....

Boston, NY160 participantsMedtronic Cardiac Surgery

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NCT04380740Recruiting

Extended vs Short-term Abatacept Dosing for Graft Versus Host Disease Prophylaxis

This is a multicenter randomized, double blind, Phase 2 trial for patients receiving transplants from 7 of 8 HLA matched donors, in which an extended dosing regimen of abatacept, and a short-term dosi...

Boston, NY160 participantsBoston Children's Hospital

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NCT07131592Recruiting

Effect of Intravenous and Topical Tranexamic Acid on Drain Output in Breast Reduction Surgery

This study aims to evaluate whether tranexamic acid (TXA), a medication that helps reduce bleeding, can decrease fluid drainage after breast reduction surgery. Participants will be randomly assigned t...

Boston, NY160 participantsMassachusetts General Hospital

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NCT04880265Recruiting

Assessing the Burden of Perioperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery

Background and Significance: In the United States approximately 220,000 patients undergo cardiac surgery per annum. Among potential complications, the incidence of atrial fibrillation (AF) is estimat...

Boston, NY150 participantsBrigham and Women's Hospital

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NCT06400004Recruiting

Lumason® Infusion vs. Bolus Administrations

A phase III study designed as a randomized, within-patient comparison of continuous infusion of diluted Lumason® versus the bolus administration of undiluted Lumason® for degree of LVO and assessment ...

Boston, NY106 participantsBracco Diagnostics, Inc

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NCT07546786Recruiting

Cognitive Function and Affective Regulation in Meditators

This is a prospective cohort study with 52 meditators and 52 controls. These groups will be contacted at a singular timepoint, during which they will take surveys and cognitive tests, which will be us...

Boston, NY104 participantsBalachundhar Subramaniam

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NCT06936566Recruiting

MAGIC Ruxolitinib for aGVHD

This clinical trial will study ruxolitinib-based treatment of acute graft-versus-host-disease (GVHD) that developed following allogeneic hematopoietic cell transplant. Acute GVHD occurs when donor cel...

Boston, NY98 participantsJohn Levine

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NCT07013591Recruiting

Nicotinamide Mononucleotide in Patients Undergoing CABG Surgery

The investigators will perform a phase 2a, randomized, double-blind, placebo-controlled clinical trial in adult patients undergoing elective coronary artery bypass grafting (CABG) surgery to investiga...

Boston, NY90 participantsBrigham and Women's Hospital

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NCT05996627Recruiting

Belumosudil for the Pre-emptive Treatment of Patients With Chronic Graft Versus Host Disease

This phase II trial compares the effect of belumosudil to a placebo in treating patients with chronic graft versus host disease. Chronic graft versus host disease remains a major complication of stem ...

Boston, NY82 participantsFred Hutchinson Cancer Center

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NCT07011810Recruiting

Axatilimab for Sclerotic Chronic Graft-versus-Host Disease

This phase II trial tests how well axatilimab works in treating patients with thickening or hardening (sclerosis) of the skin related to chronic graft-versus-host disease after a donor stem cell trans...

Boston, NY50 participantsFred Hutchinson Cancer Center

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NCT06619561Recruiting

A Study to Evaluate Vimseltinib in Adults With Active Chronic Graft-Versus-Host Disease (cGVHD)

The purpose of this study is to determine if vimseltinib is safe, tolerable and works effectively to treat adults with active moderate to severe cGVHD. Participants will be treated with vimseltinib in...

Boston, NY48 participantsDeciphera Pharmaceuticals, LLC

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NCT06960616Recruiting

Improving Clinical Efficiency by Reducing Scheduled Follow-ups Using Cochlear America's Population Mean Mapping Strategy

The study is about the importance of each follow-up visit after activating a new cochlear implant in addition to evaluating the effectiveness and efficiency of a new programming strategy from Cochlear...

Boston, NY48 participantsMassachusetts Eye and Ear Infirmary

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NCT05236062Recruiting

Impact of Exercise on the Complications of Corticosteroids in Patients With GVHD: the RESTART Trial

This study is about determining if an aerobic and resistance exercise intervention is feasible in patients diagnosed with acute or chronic GVHD (Graft-Versus-Host Disease) after having an allogeneic s...

Boston, NY36 participantsDana-Farber Cancer Institute

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NCT05642455Recruiting

SPEARHEAD-3 Pediatric Study

This is a pediatric basket study to investigate the safety and efficacy of afamitresgene autoleucel in HLA-A\*02 eligible and MAGE-A4 positive subjects aged 2-17 years of age with advanced cancers....

Boston, NY20 participantsAdaptimmune

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NCT07166848Recruiting

Electrostimulation Study for Ocular Graft vs. Host Disease

This trial is testing to see if electrostimulation treatment (ET) will be effective in treating those with ocular Graft vs. Host Disease....

Boston, NY15 participantsZhonghui K. Luo, MD, PhD

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About Atrial Fibrillation Clinical Trials in Boston

Atrial fibrillation (AFib) is the most common type of heart arrhythmia, causing an irregular and often rapid heartbeat. It significantly increases the risk of stroke, heart failure, and other complications. Treatment includes blood thinners, heart rate or rhythm control medications, and procedures like ablation.

There are currently 28 atrial fibrillation clinical trials recruiting participants in Boston, NY. These studies are seeking a combined 18,951 participants. Research is being sponsored by VA Office of Research and Development, China National Center for Cardiovascular Diseases, McMaster University and 18 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Atrial Fibrillation Clinical Trials in Boston — FAQ

Are there atrial fibrillation clinical trials in Boston?

Yes, there are 28 atrial fibrillation clinical trials currently recruiting in Boston, NY. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Boston?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you about next steps.

Are clinical trials in Boston free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Boston studies also compensate for your time and travel.

What atrial fibrillation treatments are being tested?

The 28 active trials in Boston are testing new therapies including novel drugs, biologics, and treatment approaches for atrial fibrillation.

Data updated July 13, 2026 from ClinicalTrials.gov