NCT07013591 · Brigham and Women's Hospital
Nicotinamide Mononucleotide in Patients Undergoing CABG Surgery
What this study is about
The investigators will perform a phase 2a, randomly assigned, where neither patients nor doctors know which treatment is given, compared against an inactive treatment clinical trial in adult patients undergoing elective coronary artery bypass grafting (CABG) surgery to investigate the effects of taken by mouth nicotinamide mononucleotide (NMN) administration on myocardial NAD+ concentrations and on postoperative markers of myocardial and kidney injury.
View original scientific description
The investigators will perform a phase 2a, randomized, double-blind, placebo-controlled clinical trial in adult patients undergoing elective coronary artery bypass grafting (CABG) surgery to investigate the effects of oral nicotinamide mononucleotide (NMN) administration on myocardial NAD+ concentrations and on postoperative markers of myocardial and kidney injury.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Age ≥18 years
- Scheduled to undergo elective isolated CABG surgery with cardiopulmonary bypass (CPB)
- At increased risk of postoperative complications based on ≥1 of the following:
- Age ≥65 years
- eGFR \<45 ml/min/1.73m2
- Documented history of congestive heart failure or left ventricular ejection fraction (LVEF) ≤40% within 6 months before surgery
- Diabetes mellitus and urine albumin-to-creatinine ratio \>30 mg/g creatinine
- Peripheral arterial disease
- Anemia, defined as hemoglobin \<10 g/dl
- Prior cardiac surgery
Exclusion criteria
- Any of the following laboratory abnormalities at the time of screening:
- ALT \>3-fold the upper limit of normal
- eGFR \<30 ml/min/1.73m2 or ESKD on dialysis
- Hemoglobin \<8 g/dl
- History of gastric bypass or malabsorption
- Active alcohol or illicit substance use in the prior 6 months
- Participation in an investigational trial to evaluate pharmaceuticals or biologics within the past 3 months or 5 half-lives, whichever is shorter
- Pregnant or breast-feeding
- Unwillingness to use contraception while taking study drug and for 8 weeks after the last dose for women of reproductive age or non-sterilized male participants who are sexually active with a female partner of childbearing potential
- Current use of niacin \>100 mg/day or NMN, nicotinamide, or nicotinamide riboside at any dose
- Conflict with other research studies
- Any condition which, in the judgement of the investigator, might increase the risk to the participant
Where
- Boston, Massachusetts
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jun 26, 2026 · Source of record for eligibility and locations