17 Ulcerative Colitis Clinical Trials in Chapel Hill, NC (2026)

Q: How do I join a clinical trial in Chapel Hill?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Chapel Hill research site will contact you.

Recruiting Ulcerative Colitis Studies in Chapel Hill

NCT03487185Recruiting

Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy

A randomized controlled trial of 1,500 women to assess whether treatment of obstructive sleep apnea with continuous positive airway pressure (CPAP) in pregnancy will result in a reduction in the rate ...

Chapel Hill, NCNA1,500 participantsThe George Washington University Biostatistics Center

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NCT07198113Recruiting

COMPARE - Pediatric Inflammatory Bowel Disease (PIBD)

The purpose of the study is to compare the clinical effectiveness and safety of newer inflammatory bowel disease (IBD) medications in anti-tumor necrosis factor (TNF) refractory patients with pediatri...

Chapel Hill, NC1,100 participantsUniversity of North Carolina, Chapel Hill

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NCT00360646Recruiting

Drug-Induced Liver Injury (DILI) Network Retrospective

The purpose of this study is to establish retrospectively a nationwide registry of patients who have suffered drug-induced liver injury (DILI), and to collect, immortalize, and store serum, DNA, and l...

Chapel Hill, NC400 participantsDuke University

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NCT05924477Recruiting

Glaucoma Drainage Device and Endothelial Cell Loss Compare Trial

Glaucoma Drainage Device and Endothelial Cell Loss Compare Trial (DECLARE) is a multi-center, outcome-masked, randomized clinical trial. The purpose of this study is to compare glaucoma drainage devic...

Chapel Hill, NCNA226 participantsUniversity of Pennsylvania

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NCT06750731Recruiting

Study of Efficacy and Adherence to Subcutaneous vs. Intravenous Vedolizumab in Patients With Inflammatory Bowel Disease Using a Novel Remote MONITORing Intervention

The goal of this observational study is to assess the feasibility and effectiveness of a remote monitoring digital health system on adherence, clinical outcomes, and healthcare utilization in patients...

Chapel Hill, NC200 participantsMercy Medical Center

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NCT07237516Recruiting

Zymfentra (Infliximab-dyyb) REal World Cohort STudy

The goal of this observational study is to learn about how effective Zymfentra (IFX=dyyb) is when treating patients with Crohn's disease (CD) and ulcerative colitis (UC) Does Zymfentra lead to a reduc...

Chapel Hill, NC200 participantsUniversity of North Carolina, Chapel Hill

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NCT07644559Recruiting

A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Pancreatic Cancer

This study will assess the safety and efficacy of VS-7375 alone and in combination with cetuximab in patients with metastatic KRAS G12D - mutated Pancreatic Cancer...

Chapel Hill, NCPHASE2180 participantsVerastem, Inc.

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NCT06603246Recruiting

A Study to Test the Safety and Effects of Inhaled GDC-6988 in Participants With Muco-Obstructive Disease

This study evaluates the safety, tolerability, and activity of inhaled GDC-6988 in participants with muco-obstructive disease....

Chapel Hill, NCPHASE1128 participantsGenentech, Inc.

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NCT06696014Recruiting

Mirikizumab Real World Protocol

The goal of this observational study is to learn about how effective mirikizumab (Omvoh) is when treating patients with ulcerative colitis (UC) Does mirikizumab (Omvoh) lead to a reduction in symptom...

Chapel Hill, NC100 participantsUniversity of North Carolina, Chapel Hill

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NCT07599462Recruiting

Pilot Study of Communication for Dual Users of Cigarettes and E-cigarettes

The study is a pilot test of effectiveness of communication campaign ads on interest in quitting combustible cigarettes and e-cigarettes. Over the course of 5 weeks, participants are sent ads that are...

Chapel Hill, NCNA90 participantsUNC Lineberger Comprehensive Cancer Center

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NCT05848622Recruiting

Gait Rehabilitation to Treat FastOA

The purpose of this study is to determine the effects of real-time gait biofeedback delivered over a 6-week period on early markers of FastOA and conduct 6-week and 6-month follow-up assessments in an...

Chapel Hill, NCNA70 participantsUniversity of North Carolina, Chapel Hill

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NCT06186752Recruiting

Feasibility Test of Action Planning in Pediatric IBD

The goal of this interventional study is to test the feasibility of a new communication tool, call MyIBD, in youth ages 13 to 19 years with inflammatory bowel disease. The main question\[s\] it aims t...

Chapel Hill, NCNA60 participantsUniversity of North Carolina, Chapel Hill

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NCT05949177Recruiting

Graded Exposure and Mindfulness Meditation for Patients Post-ACL Reconstruction

To evaluate the effect of graded exposure and mindfulness meditation after ACLR, the investigators will determine the effect of graded exposure and mindfulness meditation to 1) decrease self-reported ...

Chapel Hill, NCNA50 participantsUniversity of North Carolina, Chapel Hill

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NCT05527171Recruiting

Virtual Reality Mindfulness Meditation After ACL Reconstruction

To evaluate the effect of virtual reality mindfulness meditation on patients after ACLR, the investigators will determine the effect of virtual reality mindfulness meditation to 1) decrease self-repor...

Chapel Hill, NCNA48 participantsUniversity of North Carolina, Chapel Hill

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NCT03977233Recruiting

Tumor Subtypes in Subjects on FOLFIRINOX With Non-Metastatic Pancreatic Cancer

This is a research study to evaluate how the genetic makeup of Pancreatic Ductal Adenocarcinoma (PDAC) can affect the response to FDA-approved chemotherapy treatment, FOLFIRINOX, given before surgery ...

Chapel Hill, NCPHASE245 participantsUNC Lineberger Comprehensive Cancer Center

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NCT06864403Recruiting

Mirikizumab in the Treatment of Chronic Inflammatory Conditions of the Pouch

The goal of this clinical trial is to learn if mirikizumab works to treat pouch disorders in adults. The main questions it aims to answer are: Does mirikizumab reduce symptoms of pouch disorders Par...

Chapel Hill, NCPHASE425 participantsUniversity of North Carolina, Chapel Hill

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NCT06312683Recruiting

Rifaximin for the Secondary Prevention of Recurrent Pouchitis

Although many people will develop recurrent pouchitis (inflammation of the ileal pouch-anal anastomosis or J-pouch after colectomy for ulcerative colitis) after an initial episode of pouchitis, there ...

Chapel Hill, NCPHASE416 participantsUniversity of North Carolina, Chapel Hill

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About Ulcerative Colitis Clinical Trials in Chapel Hill

Ulcerative colitis is a chronic inflammatory bowel disease that causes inflammation and ulcers in the innermost lining of the colon and rectum. It typically presents with bloody diarrhea, abdominal pain, and urgency. Treatment includes aminosalicylates, corticosteroids, immunosuppressants, and biologics.

There are currently 17 ulcerative colitis clinical trials recruiting participants in Chapel Hill, NC. These studies are seeking a combined 4,438 participants. Research is being sponsored by The George Washington University Biostatistics Center, University of North Carolina, Chapel Hill, Duke University and 5 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Ulcerative Colitis Clinical Trials in Chapel Hill — FAQ

Are there ulcerative colitis clinical trials in Chapel Hill?

Yes, there are 17 ulcerative colitis clinical trials currently recruiting in Chapel Hill, NC. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Chapel Hill?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Chapel Hill research site will contact you about next steps.

Are clinical trials in Chapel Hill free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Chapel Hill studies also compensate for your time and travel.

What ulcerative colitis treatments are being tested?

The 17 active trials in Chapel Hill are testing new therapies including novel drugs, biologics, and treatment approaches for ulcerative colitis.

Data updated July 18, 2026 from ClinicalTrials.gov