11 Depression Clinical Trials in Charleston, SC (2026)

Q: How do I join a clinical trial in Charleston?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Charleston research site will contact you.

Recruiting Depression Studies in Charleston

NCT06582784Recruiting

IMPACT (IMproving Proactive Approaches for Cancer Survivors' Mental Health Treatment)

The purpose of this research study is to evaluate a mobile application (app) for depression treatment called "Moodivate" among cancer survivors. Moodivate was developed by our research team to assist ...

Charleston, SCNA279 participantsMedical University of South Carolina

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NCT07210255Recruiting

SAINT in Postpartum Depression (PPD)

This study is a large, multi-site clinical trial testing whether Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT), a fast-acting form of repetitive transcranial magnetic stimulation (r...

Charleston, SCNA192 participantsMagnus Medical

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NCT04877197Recruiting

Behavioral Activation Delivered Via Home-based Telehealth to Improve Functioning in Cardiovascular Disease Patients Recently Discharged From Inpatient Care

The purpose of this study is to demonstrate whether Behavioral Activation for depression delivered via home based telehealth (BA-HT) is effective in improving social and role functioning in Veterans r...

Charleston, SCNA132 participantsVA Office of Research and Development

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NCT05977439Recruiting

RECOVERS - Realigning Emotion and COgnition Via prEcision Regulation networkS

In this research study, investigators examine how brain activity changes during tests of emotional processing, attention, and memory using multimodal neuroimaging methods including electroencephalogra...

Charleston, SCNA120 participantsMedical University of South Carolina

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NCT03417960Recruiting

Accelerated iTBS for Post Partum Depression

Study 1: The investigators are studying the feasibility and tolerability of 10x/day intermittent theta burst (excitatory) transcranial magnetic stimulation to the left dorsolateral prefrontal cortex o...

Charleston, SCNA40 participantsMedical University of South Carolina

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NCT07634705Recruiting

Digitally Enhanced Stepped-Care for Depression in Primary Care

This pilot, three-arm randomized clinical trial (N=40; 2:1:1) will evaluate the feasibility and preliminary efficacy of a digitally enhanced stepped-care approach for depression treatment in primary c...

Charleston, SCNA40 participantsMedical University of South Carolina

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NCT06748209Recruiting

Establishing Mobile Transcranial Magnetic Stimulation

In this pilot study, investigators propose to design and create a portable TMS unit, in a van, and then test out delivering TMS in three different locations in South Carolina, all affiliated with MUSC...

Charleston, SCPHASE430 participantsMedical University of South Carolina

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NCT05725239Recruiting

taVNS or TMS or Both for Depression

The purpose of the research is to test out a combined treatment for depression where the investigators stimulate a nerve in the ear while at the same time stimulate the brain with magnets. These treat...

Charleston, SCNA24 participantsMedical University of South Carolina

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NCT07369557Recruiting

Mindfulness Training During Accelerated TMS for Depression

This NIH-funded single-arm pilot tests the feasibility, acceptability, and preliminary effects of embedding brief guided mindfulness practice (via the Waking Up smartphone app) into the inter-session ...

Charleston, SCNA20 participantsMedical University of South Carolina

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NCT06562153Recruiting

fMRI Accelerated TMS Depression

This study aims to investigate whether phenotypic-related brain states revealed by a novel INSCAPE ("Individualized Network-based Single-frame Coactivation Pattern Estimation") neuroimaging method in ...

Charleston, SC20 participantsMedical University of South Carolina

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NCT04263285Recruiting

Treatment of Depression Post-SCI

Depression is more common after a spinal cord injury (SCI) than in the general population. Unfortunately, it is unknown how depression is typically treated in individuals with SCI or if commonly used ...

Charleston, SCNA14 participantsMedical University of South Carolina

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About Depression Clinical Trials in Charleston

Depression (major depressive disorder) is a common and serious mood disorder that negatively affects how you feel, think, and handle daily activities. It affects over 280 million people globally. Treatment includes psychotherapy, antidepressant medications, and brain stimulation therapies.

There are currently 11 depression clinical trials recruiting participants in Charleston, SC. These studies are seeking a combined 911 participants. Research is being sponsored by Medical University of South Carolina, Magnus Medical, VA Office of Research and Development. Clinical trial participation is free and participants receive study-related medical care at no cost.

Depression Clinical Trials in Charleston — FAQ

Are there depression clinical trials in Charleston?

Yes, there are 11 depression clinical trials currently recruiting in Charleston, SC. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Charleston?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Charleston research site will contact you about next steps.

Are clinical trials in Charleston free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Charleston studies also compensate for your time and travel.

What depression treatments are being tested?

The 11 active trials in Charleston are testing new therapies including novel drugs, biologics, and treatment approaches for depression.

Data updated September 5, 2026 from ClinicalTrials.gov